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A comparative histopathological study of vocal fold polyps in smokers versus non-smokers

Published online by Cambridge University Press:  19 March 2015

K G Effat  and
M Milad
K G Effat*
Affiliation:
Department of Otolaryngology, El-Sahel Teaching Hospital, Cairo, Egypt
M Milad
Affiliation:
Department of Pathology, Cairo University Hospital, Egypt
*
Address for correspondence:Dr K G Effat, 6 Falaky Square, Cairo, Egypt E-mail: [email protected]
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Abstract

Background:

A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been performed.

Methods:

A prospective histopathological study of vocal fold polyps excised from 29 patients was undertaken. This comprised a comparative analysis of polyp histopathology in smokers versus non-smokers and a review of the pertinent literature.

Results:

Vocal fold polyps were larger in smokers than in non-smokers. Histopathological features significantly associated with the polyps of smokers versus those of non-smokers were increased keratinisation, dysplasia, a basement membrane thinning and hyaline degeneration.

Conclusion:

Cigarette smoke has an injurious effect on vocal fold polyp epithelium and leads to increased hyaline degeneration in polyps.

Keywords

Vocal foldPolypsSmokingHistopathology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 5 , May 2015 , pp. 484 - 488
Copyright
Copyright © JLO (1984) Limited 2015 

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References

1Rosen, CA, Gartner-Schmidt, J, Hathaway, B, Blacke Simpson, C, Postma, GN, Courey, M et al. A nomenclature paradigm for benign midmembranous vocal fold lesions. Laryngoscope 2012;122:1335–41CrossRefGoogle ScholarPubMed
2Kleinsasser, O. Pathogenesis of vocal cord polyps. Ann Otol Rhinol Laryngol 1982;91:378–81CrossRefGoogle ScholarPubMed
3Kambic, V, Radsel, Z, Zargi, M, Acko, M. Vocal cord polyps: incidence, histology and pathogenesis. J Laryngol Otol 1981;95:609–18CrossRefGoogle ScholarPubMed
4Gunter, HE.Modeling mechanical stresses as a factor in the etiology of benign vocal fold lesions. J Biomech 2004;37:1119–24CrossRefGoogle ScholarPubMed
5Li, NYK, Vodovotz, Y, Kim, KH, Mi, Q, Hebda, PA, Abbott, KV. Biosimulation of acute phonotrauma: an extended model. Laryngoscope 2011;121:2418–28CrossRefGoogle ScholarPubMed
6Martins, RHG, Defaveri, J, Domingues, MAC, de Albuquerque e Silva, R. Vocal polyps: clinical, morphological, and immunohistochemical aspects. J Voice 2011;25:98–106CrossRefGoogle ScholarPubMed
7Gale, N, Zidar, N, Fischinger, J, Kambic, V. Clinical applicability of the Ljubljana classification of epithelial hyperplastic laryngeal lesions. Clin Otolaryngol 2000;25:227–32CrossRefGoogle ScholarPubMed
8Hantzakos, A, Remacle, M, Dikkers, FG, Degols, J-C, Delos, M, Friedrich, G et al. Exudative lesions of Reinke's space: a terminology proposal. Eur Arch Otorhinolaryngol 2009;266:869–78CrossRefGoogle ScholarPubMed
9Banjara, H, Mungutwar, V, Singh, D, Gupta, A. Objective and subjective evaluation of larynx in smokers and non-smokers: a comparative study. Indian J Otolaryngol Head Neck Surg 2014;66(suppl1):S99–S109CrossRefGoogle Scholar
10Dikkers, FG, Nikkels, PGJ. Lamina propria of the mucosa of benign lesions of the vocal folds. Laryngoscope 1999;109:1684–9CrossRefGoogle ScholarPubMed
11Li-jing, M, Jun, W, Yang, X, Jing-ying, Y, Wen, X, Quing-wen, Y. Clinical classification and treatment of leukokeratosis of the vocal cords. Chin Med J 2013;126:3523–7Google Scholar
12Isenberg, JS, Crozier, DL, Dailey, SH. Institutional and comprehensive review of laryngeal leukoplakia. Ann Otol Rhinol Laryngol 2008;117:74–9CrossRefGoogle ScholarPubMed
13Sadri, M, McMahon, J, Parker, A. Laryngeal dysplasia: aetiology and molecular biology. J Laryngol Otol 2006;120:170–7CrossRefGoogle ScholarPubMed
14Smit, CF, Copper, MP, van Leeuwen, JAMJ, Schoots, IG, Stanojcic, LD. Effect of cigarette smoking on gastropharyngeal and gastroesophageal reflux. Ann Otol Rhinol Laryngol 2001;110:190–3CrossRefGoogle ScholarPubMed
15Courey, MS, Shohet, JA, Scott, MA, Ossoff, RH. Immunohistochemical characterization of benign laryngeal lesions. Ann Otol Rhinol Laryngol 1996;105:523–31CrossRefGoogle ScholarPubMed
16Hohberger, L, Wuertz, BRK, Xie, H, Griffin, T, Ondrey, F. TNF-α drives matrix metalloproteinase-9 in squamous oral carcinogenesis. Laryngoscope 2008;118:1395–9CrossRefGoogle ScholarPubMed
17Zhou, L, Xie, M, Zhou, JQ, Tao, L. 67-k Da laminin receptor in human laryngeal squamous cell carcinoma. Laryngoscope 2006;116:28–32CrossRefGoogle Scholar
18Johns, MM. Update on the etiology, diagnosis, and treatment of vocal fold nodules, polyps, and cysts. Curr Opin Otolaryngol Head Neck Surg 2003;11:456–61CrossRefGoogle ScholarPubMed
19Altman, KW. Vocal fold masses. Otolaryngol Clin North Am 2007;40:1091–108CrossRefGoogle ScholarPubMed
20Jiang, JJ, Diaz, CE, Hanson, DG. Finite element modeling of vocal fold vibration in normal phonation and hyperfunctional dysphonia: implications for the pathogenesis of vocal nodules. Ann Otol Rhinol Laryngol 1998;107:603–10CrossRefGoogle ScholarPubMed
21Zhang, Y, Jiang, JJ. Chaotic vibrations of a vocal fold model with a unilateral polyp. J Acoust Soc Am 2004;115:1266–9CrossRefGoogle ScholarPubMed
22Wallis, L, Jackson-Menaldi, C, Holland, W, Giraldo, A. Vocal fold nodule vs. vocal fold polyp: answer from surgical pathologist and voice pathologist point of view. J Voice 2004;18:125–9CrossRefGoogle ScholarPubMed
23Cipriani, NA, Martin, DE, Corey, JP, Portugal, L, Caballero, N, Lester, R et al. The clinicopathologic spectrum of benign mass lesions of the vocal fold due to vocal abuse. Int J Surg Pathol 2011;19:583–7CrossRefGoogle ScholarPubMed
24Walter, JB, Israel, MS. Connective tissue: its normal structure and the effects of disease. In: Walter, JB, Israel, MS, eds. General Pathology, 5th edn.Edinburgh: Churchill Livingstone, 1979;59–70Google Scholar