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Cluster of differentiation 8 T-cell population in the laryngeal mucosa of smokers with laryngeal cancer

Published online by Cambridge University Press:  24 January 2019

S Elwany ,
S Radi ,
H Khalil ,
I Talaat  and
K Belasy
S Elwany*
Affiliation:
Department of Otolaryngology, Alexandria Faculty of Medicine, Egypt
S Radi
Affiliation:
Department of Histology, Alexandria Faculty of Medicine, Egypt
H Khalil
Affiliation:
Department of Otolaryngology, Peninsula School of Medicine, Derriford Hospital, Plymouth, UK
I Talaat
Affiliation:
Department of Pathology, Alexandria Faculty of Medicine, Egypt Department of Clinical Sciences, Sharjah University, Sharjah, UAE
K Belasy
Affiliation:
Department of Otolaryngology, Cairo Police Hospital, Egypt
*
Author for correspondence: Dr Samy Elwany, Department of Otolaryngology, Alexandria Faculty of Medicine, Alexandria, Egypt E-mail: [email protected]
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Abstract

Objective

To study the cluster of differentiation 8 population in the laryngeal mucosa of patients with laryngeal carcinoma. To our knowledge this is the first paper to address this issue.

Methods

The study group included 40 patients with known laryngeal cancer who were scheduled for laryngectomy. The control groups included 10 smokers and 10 non-smokers who were scheduled for microlaryngeal surgery. Specimens from the three groups were processed for histopathological and histochemical evaluation.

Results

In patients without cancer of the larynx, the number of cluster of differentiation 8 lymphocytes was greater in smokers than non-smokers. The number of cluster of differentiation 8 lymphocytes was greatest in smokers with laryngeal cancer, and the difference between this group and the two control groups was statistically significant.

Conclusion

The study showed that smoking increased the number of cluster of differentiation 8 T-lymphocytes in the laryngeal mucosa. The increase was greatest in patients who had developed laryngeal cancer.

Keywords

LarynxCD8 AntigensT-LymphocytesSmokingTobaccoCarcinoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 12 , December 2018 , pp. 1134 - 1137
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr S Elwany takes responsibility for the integrity of the content of the paper

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