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Can curcumin modulate allergic rhinitis in rats?

Published online by Cambridge University Press:  06 October 2016

M Acar ,
N Bayar Muluk ,
S Yigitaslan ,
B P Cengiz ,
P Shojaolsadati ,
H Karimkhani ,
S Ada ,
M Berkoz  and
C Cingi
M Acar
Affiliation:
ENT, Yunus Emre State Hospital, Eskişehir, Turkey
N Bayar Muluk*
Affiliation:
ENT Department, Medical Faculty, Kırıkkale University, Turkey
S Yigitaslan
Affiliation:
Department of Pharmacology, Eskişehir Osmangazi University, Turkey
B P Cengiz
Affiliation:
Pathology Clinics, Yunus Emre State Hospital, Eskişehir, Turkey
P Shojaolsadati
Affiliation:
Department of Anatomy, Eskişehir Osmangazi University, Turkey
H Karimkhani
Affiliation:
Department of Biochemistry, Eskişehir Osmangazi University, Turkey
S Ada
Affiliation:
ENT Department, Luleburgaz State Hospital, Ankara, Turkey
M Berkoz
Affiliation:
Pharmaceutical Biotechnology Department, Faculty of Pharmacy, Yüzüncü Yıl University, Van, Turkey
C Cingi
Affiliation:
Department of ENT, Eskişehir Osmangazi University, Turkey
*
Address for correspondence: Dr Nuray Bayar Muluk, Birlik Mahallesi, Zirvekent 2. Etap Sitesi, C-3 blok, No: 62/43, 06610 Çankaya / ANKARA, Turkey Fax: +90 312 4964073 E-mail: [email protected]
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Abstract

Objectives:

This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats.

Methods:

Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21–28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21–28. Allergy symptoms and histopathological features of the nasal mucosa were examined.

Results:

The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria.

Conclusion:

Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.

Keywords

CurcuminRhinitisAllergicPerennialRats
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 12 , December 2016 , pp. 1103 - 1109
Copyright
Copyright © JLO (1984) Limited 2016 

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