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Bacterial coating with immunoglobulins on the palatine tonsils during infectious mononucleosis: immunocytochemical study with gold markers

Published online by Cambridge University Press:  08 March 2006

Lars-Eric Stenfors ,
Helga-Marie Bye  and
Simo Räisänen
Lars-Eric Stenfors
Affiliation:
Department of Otolaryngology, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.
Helga-Marie Bye
Affiliation:
Department of Otolaryngology, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.
Simo Räisänen
Affiliation:
Department of Otolaryngology, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.
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Abstract

Epithelial cells and bacteria were sampled from the tonsillar surfaces of seven patients (six males, one female; median age 16 years, range 10 to 21 years) suffering from acute infectious mononucleosis with concomitant pharyngotonsillitis. By using gold-labelled antiserum to human IgG and secretory IgA (sIgA), micro-organisms on the tonsillar surfaces coated with these immunoglobulins could be identified by tracing the gold particles in the transmission electron microscope. The patients harboured significantly fewer bacteria coated with immunoglobulins than did healthy controls. More bacteria were coated with IgG immunoglobulins than with sIgA. Reduced immunoglobulin-coating of the bacteria on the tonsillar surfaces during infectious mononucleosis can explain their tendency to immense local colonization and proneness to penetrate into the epithelial cells.

Keywords

Epstein-BarrVirus InfectionsImmunityMucosalTonsillitisBacterial AdhesionInflammation
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 115 , Issue 2 , February 2001 , pp. 101 - 105
Copyright
© Royal Society of Medicine Press Limited 2001

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