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Association between osteoporosis and otosclerosis in women

Published online by Cambridge University Press:  08 March 2006

Amy E. Clayton ,
Anthony A. Mikulec ,
Katharine H. Mikulec ,
Saumil N. Merchant  and
Michael J. McKenna
Amy E. Clayton
Affiliation:
University of Wales College of Medicine, Cardiff, UK.
Anthony A. Mikulec
Affiliation:
Department of Otology and Laryngology, Harvard Medical School, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Katharine H. Mikulec
Affiliation:
Division of Endocrinology, Diabetes, and Hypertension, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA.
Saumil N. Merchant
Affiliation:
Department of Otology and Laryngology, Harvard Medical School, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Michael J. McKenna
Affiliation:
Department of Otology and Laryngology, Harvard Medical School, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
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Abstract

Similarities between osteoporosis and otosclerosis have been noted, including a similar association with the COL1A1 gene. Herein, the authors explore the possible clinical relationship between these two common disorders of bone. In this retrospective study, the medical charts of 100 women aged 50 through 75 years who had undergone stapedectomy for otosclerosis were reviewed and the prevalence of osteoporosis in these women was noted. Similarly, the prevalence of osteoporosis was determined in a control group of 100 women aged 50 to 75 years with presbycusis. Fifteen of 100 women with otosclerosis had a concomitant diagnosis of osteoporosis as compared with four of 100 women with presbycusis, yielding a significant clinical association (p = 0.007) between otosclerosis and osteoporosis. This study suggests an association between otosclerosis and osteoporosis, providing impetus and justification for future prospective clinical studies and related research.

Keywords

OtosclerosisOsteoporosisCollagen Type 1Genes
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 118 , Issue 8 , August 2004 , pp. 617 - 621
Copyright
© 2004 Royal Society of Medicine Press

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