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Antimicrobial Prophylaxis for Major head and neck cancer surgery with piperacillin and ornidazole

Published online by Cambridge University Press:  29 June 2007

L. Dominici ,
R. Gondret ,
V. Broc ,
S. Dubos ,
M. Viallard  and
P. Deligne
L. Dominici*
Affiliation:
Paris, France
R. Gondret
Affiliation:
Paris, France
V. Broc
Affiliation:
Paris, France
S. Dubos
Affiliation:
Paris, France
M. Viallard
Affiliation:
Paris, France
P. Deligne
Affiliation:
Paris, France
*
Docteur Lionel Dominici, Departement d'Anesthesie, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France.
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Abstract

A prospective study in 53 eligible patients, undergoing major head and neck cancer surgery was carried out to assess the combination of an ureido penicillin, piperacillin with a nitro imidazole agent, ornidazole, in order to prevent post-operative general and wound infections. Both antibiotics were administered for five days. Each patient had piperacillin 4 gm every eight hours and ornidazole 1 gm every 24 hours.

The overall rate of infections was 13.2 per cent (n = 7), with 3.8 per cent (n = 2) wound infections and 11.3 per cent (n = 6) general infections (one patient presented both complications).

There was no wound infection in the total surgery group (n = 12). General infections who only consisted of pneumonias were respectively 12.2 per cent (n - 5) in the group with partial procedures (n = 41) and 8.3 per cent (n = 1) in the total surgery group.

This antibioprophylaxis can be recommended in major oncological neck surgery, specially in the case of partial procedures.

Keywords

AntibioticscombinedPiperacillinOrnidazoleHead and neck neoplasmsSurgery
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 5 , May 1992 , pp. 409 - 411
Copyright
Copyright © JLO (1984) Limited 1992

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References

Altemeier, W. A., Culbertson, W. R., Vetto, M. (1955) Prophylactic antibiotic therapy. Archives of Surgery, 71: 2–6.CrossRefGoogle ScholarPubMed
Becker, G. D. (1985) Ineffectiveness of closed suction drainage cultures in the prediction of bacteriologic findings in wound infections in patients undergoing contaminated head and neck cancer surgery. Otolaryngology—Head and Neck Surgery, 93: 743–747.CrossRefGoogle ScholarPubMed
Becker, G. D. (1986) Identification and management of the patient at high risk for wound infection. Head and Neck Surgery, 8: 205–210.CrossRefGoogle ScholarPubMed
Brown, B. M., Johnson, J. T., Wagner, R. L. (1987) Etiologic factors in head and neck wound infections. Laryngoscope, 97: 587–590.CrossRefGoogle ScholarPubMed
Cole, R. R., Robbins, K. T., Cohen, J. I., Wolf, P. F. (1987) A predictive model for wound sepsis in oncologic surgery of the head and neck. Otolaryngology—Head and Neck Surgery, 96: 167–171.CrossRefGoogle ScholarPubMed
Coussins, V. C, Milton, C. M., Bickerton, R. C. (1987) Hospital morbidity and mortality following total laryngectomy experience of 374 operations. Journal of Laryngology and Otology, 101: 1159–1164.CrossRefGoogle Scholar
Gerard, M., Meunier, E., Dor, P., Andry, G., Chantrain, G., van der Auwera, P., Daneau, D., Klastersky, J. (1988) Antimicrobial prophylaxis for major head and neck surgery in cancer patients. Antimicrobial Agent and Chemotherapy, 32: 1557–1559.CrossRefGoogle ScholarPubMed
Johnson, J. T., Myers, E. N., Sigler, B. A., Thearle, P. B., Schramm, V. L. (1984) Antimicrobial prophylaxis for contaminated head and neck surgery. Laryngoscope, 94: 46–51.CrossRefGoogle ScholarPubMed
Johnson, J. T., Yu, V. L., Meyrs, E. N., Wagner, R. L., Sigler, B. A. (1986) Cefazolin vs moxalactam? A double-blind randomized trial of cephalosporins in head and neck surgery. Archives of Otolaryngology, 112: 151–153.CrossRefGoogle ScholarPubMed
Mandell-Brown, M., Johnson, J. T., Wagner, R. L. (1984) Costeffectiveness of prophylactic antibiotics in head and neck surgery. Otolaryngology–Head and Neck Surgery, 92: 520–523.CrossRefGoogle ScholarPubMed
Piquet, J. J., Crinquette-Gamot, V. (1987) Evaluation de la cefuroxime pour la prevention des infections apres chirurgie ORL pour cancer. Agressologie, 28: 567–56.Google Scholar
Robbins, K. T., Byers, R. M., Fainstein, V., Schantz, S. P., Wolf, P., Cole, R., Guillamondegui, O. M., Weber, R. S., Goepfert, H. (1988) Wound prophylaxis with metronidazole in head and neck surgical oncology. Laryngoscope, 98: 803–806.CrossRefGoogle ScholarPubMed
Rubin, J. R., Johnson, J. T., Wagner, R. L., Yu, V. L. (1988) Bacteriologic analysis of wound infection following major head and neck surgery. Archives of Otolaryngology—Head and Neck Surgery, 14: 969–972.CrossRefGoogle Scholar
Saginur, R., Odell, P. F., Poliquin, J. F. (1988) Antibiotic prophylaxis in head and neck cancer surgery. Journal of Otolaryngology, 17: 78–80.Google ScholarPubMed
Swift, A. C., Bartzokas, C. A., Corkill, J. E. (1987) The clinical significance of the gastro-oral pathway of intestinal bacteria after head and neck cancer surgery. Clinical Otolaryngology, 12: 455–459.CrossRefGoogle ScholarPubMed