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Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media

Published online by Cambridge University Press:  30 May 2016

A Tatar ,
M Korkmaz ,
M Yayla ,
M S Gozeler ,
V Mutlu ,
Z Halici ,
H Uslu ,
H Korkmaz  and
J Selli
A Tatar*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Ataturk University Medical Faculty, Erzurum, Turkey
M Korkmaz
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Ordu University Medical Faculty, Turkey
M Yayla
Affiliation:
Department of Pharmacology, Ataturk University Medical Faculty, Erzurum, Turkey
M S Gozeler
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Ataturk University Medical Faculty, Erzurum, Turkey
V Mutlu
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Ataturk University Medical Faculty, Erzurum, Turkey
Z Halici
Affiliation:
Department of Pharmacology, Ataturk University Medical Faculty, Erzurum, Turkey
H Uslu
Affiliation:
Department of Microbiology, Ataturk University Medical Faculty, Erzurum, Turkey
H Korkmaz
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Ordu University Medical Faculty, Turkey
J Selli
Affiliation:
Department of Embryology and Histology, Ataturk University Medical Faculty, Erzurum, Turkey
*
Address for correspondence: Dr Arzu Tatar, Ataturk Uni. Tip Fak., Kulak-Burun-Bogaz AD, 25240-Erzurum, Turkey E-mail: [email protected]
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Abstract

Objectives:

To investigate the anti-inflammatory, anti-oxidative and tissue protective effects, as well as the potential therapeutic role, of alpha-lipoic acid in experimentally induced acute otitis media.

Methods:

Twenty-five guinea pigs were assigned to one of five groups: a control (non-otitis) group, and otitis-induced groups treated with saline, penicillin G, alpha-lipoic acid, or alpha-lipoic acid plus penicillin G. Tissue samples were histologically analysed, and oxidative parameters in tissue samples were measured and compared between groups.

Results:

The epithelial integrity was better preserved, and histological signs of inflammation and secretory metaplasia were decreased, in all groups compared to the saline treated otitis group. In the alpha-lipoic acid plus penicillin G treated otitis group, epithelial integrity was well preserved and histological findings of inflammation were significantly decreased compared to the saline, penicillin G and alpha-lipoic acid treated otitis groups. The most favourable oxidative parameters were observed in the control group, followed by the alpha-lipoic acid plus penicillin G treated otitis group.

Conclusion:

Alpha-lipoic acid, with its antioxidant, anti-inflammatory and tissue protective properties, may decrease the clinical sequelae and morbidity associated with acute otitis media.

Keywords

Otitis MediaReactive Oxygen SpeciesAlpha-Lipoic AcidInflammationGuinea Pig
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 7 , July 2016 , pp. 616 - 623
Copyright
Copyright © JLO (1984) Limited 2016 

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