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Angioedema secondary to angiotensin-converting enzyme inhibitors

Published online by Cambridge University Press:  29 June 2007

J. P. M. Pracy*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Guy's Hospital, St Thomas' Street, London SE1 9RT
J. A. McGlashan
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Guy's Hospital, St Thomas' Street, London SE1 9RT
R. M. Walsh
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Guy's Hospital, St Thomas' Street, London SE1 9RT
M. J. Gleeson
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Guy's Hospital, St Thomas' Street, London SE1 9RT
*
J. P. M. Pracy, 98 Liverpool Road, Islington, London N1 0RE.

Abstract

Angioedema secondary to angiotensin-converting enzyme (ACE) inhibitors is rare, but it is a side effect which is likely to be seen more frequently because of the increased use of these drugs to treat cardiac failure and hypertension. Presentation is variable and the diagnosis may go unrecognized for many months or years. The cases reported illustrate problems both in the diagnosis and management of this life-threatening condition.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 1994

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References

Anderson, M. W., de Shazo, R. D. (1990) Studies of the mechanism of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema: the effect of an ACE inhibitor on cutaneous responses to bradykinin, codeine, and histamine. Journal of Allergy and Clinical Immunology 85: 856858.CrossRefGoogle ScholarPubMed
Chin, H. L., Buchan, D. A. (1990) Severe angioedema after longterm use of an angiotensin-converting enzyme inhibitor. Annals of Internal Medicine 112: 312313.Google Scholar
Gannon, T. H., Eby, T. L. (1990) Angioedema from angiotensin converting enzyme inhibitors: a cause of upper airway obstruction. Laryngoscope 100: 11561160.Google Scholar
Haddad, A., Frenkiel, S., Small, P. (1985) Angioedema of the head and neck. Journal of Otolaryngology 14: 1416.Google ScholarPubMed
Hedner, T., Samuelson, O., Lindholm, L., Andren, L., Wiholm, B. (1991) Precipitation of angioedema by antihypertensive drugs. Journal of Hypertension 9 (suppl.): S360S361.Google Scholar
Jett, G. K. (1984) Captopril-induced angioedema. Annals of Emergency Medicine 13: 489490.CrossRefGoogle ScholarPubMed
Megerian, C. A., Arnold, J. E., Berger, M. (1992) Angioedema: 5 years' experience, with a review of the disorder's presentation and treatment. Laryngoscope 102: 256260.CrossRefGoogle ScholarPubMed
Milton, J. L. (1876) On giant urticaria. Edinburgh Medical Journal 22: 513526.Google Scholar
Orfan, N., Patterson, R., Dykewicz, M. S. (1990) Severe angioedema related to ACE inhibitors in patients with a history of idiopathic angioedema. Journal of the American Medical Association 264: 12871289.Google Scholar
Regoli, D., Barabe, J. (1980) Pharmacology of bradykinin and related kinins. Pharmacological Reviews 32: 146.Google ScholarPubMed
Quinke, H. (1882) Concerning the acute localized oedema of the skin. Monatshefte Praktische Dermatologie 1: 129131.Google Scholar
Roberts, J. R., Wuerz, R. C. (1991) Clinical characteristics of angiotensin-converting enzyme inhibitor-induced angioedema. Annals of Emergency Medicine 20: 555558.CrossRefGoogle ScholarPubMed
Singer, D. R., MacGregor, G. A. (1986) Angioneurotic oedema associated with two angiotensin-converting enzyme inhibitors. British Medical Journal 293: 1243.CrossRefGoogle Scholar
Slater, E. E., Merrill, D. D., Guess, H. A., Roylance, P. J., Cooper, W. D., Inman, W. H. W., Ewan, P. W. (1988) Clinical profile of angioedema associated with angiotensin-converting enzyme inhibition. Journal of the American Medical Association 260: 967970.CrossRefGoogle ScholarPubMed
Smith, M. E., Morgan, M. T. (1989) Angioedema of the head and neck and angiotensin-converting enzyme inhibitors. Otolaryngology-Head and Neck Surgery 101: 9395.Google ScholarPubMed