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Analysis of tinnitus severity and associated risk factors in patients with chronic otitis media: data from the multinational collaborative Chronic Otitis Media Questionnaire-12 study

Published online by Cambridge University Press:  10 January 2022

B V Tailor*
Affiliation:
Department of Otolaryngology, Norfolk and Norwich University Hospital, Norwich
J S Phillips
Affiliation:
Department of Otolaryngology, Norfolk and Norwich University Hospital, Norwich
I Nunney
Affiliation:
Norwich Clinical Trials Unit, Norwich Medical School, University of East Anglia, Norwich
M W Yung
Affiliation:
Department of Otolaryngology, The Ipswich Hospital NHS Trust, Ipswich
C Doruk
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Istanbul University, Turkey
H Kara
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Istanbul University, Turkey
T Kong
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Yonsei University Wonju College of Medicine, Gangwon-do, South Korea
N Quaranta
Affiliation:
Otolaryngology Unit, Department of Biomedical Sciences, Neuroscience and Sensory Organs, University of Bari ‘Aldo Moro’, Italy
A Peñaranda
Affiliation:
Fundacion Santa Fe de Bogota, Universidad de Los Andes School of Medicine, Bogota, Colombia
D Bernardeschi
Affiliation:
Department of Otolaryngology, Pitié-Salpêtrière Group Hospital, Paris, France
C Dai
Affiliation:
Department of Otology and Skull Base Surgery, Eye and Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
R Kania
Affiliation:
Department of Otolaryngology, Lariboisière University Hospital, Paris, France
F Denoyelle
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Necker-Enfants Malades Hospital, Paris, France
T Tono
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, University of Miyazaki, Japan
*
Author for correspondence: Dr B V Tailor, Department of Otolaryngology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich, NorfolkNR4 7UY, UK E-mail: [email protected]

Abstract

Background

Subjective tinnitus is a common symptom, and there is often an underlying otological cause. This study investigated the degree of tinnitus-related annoyance in patients with chronic otitis media and analysed whether associations with tinnitus severity exist.

Method

The multinational collaborative Chronic Otitis Media Questionnaire-12 study collected prospective data on 478 adult patients suffering from chronic otitis media across 9 otology referral centres in 8 countries. Based on this dataset, we investigated tinnitus severity using participant responses to item 7 of a native version of the Chronic Otitis Media Questionnaire-12.

Results

With respect to tinnitus severity, 23.8 per cent, 17.4 per cent, 15.5 per cent, and 43.4 per cent of participants reported no, minor, moderate, and major inconvenience or greater, respectively. The absence of ear discharge, absence of cholesteatoma, and poorer disease-specific health-related quality-of-life were associated with increased tinnitus severity in patients with chronic otitis media, whereas age, hearing disability and geographical region showed no association.

Conclusion

This analysis provided novel insight into potential risk factors for tinnitus in patients with chronic otitis media.

Type
Main Article
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr B V Tailor takes responsibility for the integrity of the content of the paper

References

McCormack, A, Edmondson-Jones, M, Somerset, S, Hall, D. A systematic review of the reporting of tinnitus prevalence and severity. Hearing Research 2016;337:70–9CrossRefGoogle ScholarPubMed
Han, BI, Lee, HW, Kim, TY, Lim, JS, Shin, KS. Tinnitus: characteristics, causes, mechanisms, and treatments. J Clin Neurol 2009;5:11–9CrossRefGoogle ScholarPubMed
Roberts, LE, Eggermont, JJ, Caspary, DM, Shore, SE, Melcher, JR, Kaltenbach, JA. Ringing ears: the neuroscience of tinnitus. J Neurosci 2010;30:14972–9CrossRefGoogle ScholarPubMed
Eggermont, JJ, Roberts, LE. The neuroscience of tinnitus. Trends Neurosci 2004;27:676–82CrossRefGoogle ScholarPubMed
Schaette, R, McAlpine, D. Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model. J Neurosci 2011;31:13452–7CrossRefGoogle ScholarPubMed
Mahafza, N, Zhao, F, El Refaie, A, Chen, F. A comparison of the severity of tinnitus in patients with and without hearing loss using the tinnitus functional index (TFI). Int J Audiol 2021;60:220–6CrossRefGoogle ScholarPubMed
Savastano, M. Tinnitus with or without hearing loss: are its characteristics different? Eur Arch Otorhinolaryngol 2008;265:1295–300CrossRefGoogle ScholarPubMed
Axelsson, A, Ringdahl, A. Tinnitus—a study of its prevalence and characteristics. Brit J Audiol 1989;23:5362CrossRefGoogle ScholarPubMed
Murphy, DC, Phillips, JS. An effective decision-making aid for patients with tinnitus: a retrospective review of 205 patients. Clin Otolaryngol 2020;45:818–22CrossRefGoogle ScholarPubMed
Kostev, K, Alymova, S, Kössl, M, Jacob, L. Risk factors for tinnitus in 37,692 patients followed in general practices in germany. Otol Neurotol 2019;40:436–40CrossRefGoogle ScholarPubMed
Lee, HM, Han, K do, Kong, SK, Nam, EC, Park, SN, Shim, HJ et al. Epidemiology of clinically significant tinnitus: a 10-year trend from nationwide health claims data in South Korea. Otol Neurotol 2018;39:680–7CrossRefGoogle ScholarPubMed
Sindhusake, D, Golding, M, Newall, P, Rubin, G, Jakobsen, K, Mitchell, P. Risk factors for tinnitus in a population of older adults: the blue mountains hearing study. Ear Hear 2003;24:501–7CrossRefGoogle Scholar
Kim, D-K, Park, S-N, Kim, MJ, Lee, SY, Park, K-H, Yeo, SW. Tinnitus in patients with chronic otitis media before and after middle ear surgery. Eur Arch Otorhinolaryngol 2011;268:1443–8CrossRefGoogle ScholarPubMed
Manche, SK, Madhavi, J, Meganadh, KR, Jyothy, A. Association of tinnitus and hearing loss in otological disorders: a decade-long epidemiological study in a South Indian population. Brazil J Otorhinolaryngol 2016;82:643–9CrossRefGoogle Scholar
Phillips, JS, Yung, MW. A systematic review of patient-reported outcome measures for chronic suppurative otitis media. Laryngoscope 2016;126:1458–63CrossRefGoogle ScholarPubMed
Baumann, I, Kurpiers, B, Plinkert, PK, Praetorius, M. Development and validation of the Chronic Otitis Media Outcome Test 15 (COMOT-15). Measurement of health-related quality of life in patients with chronic otitis media. HNO 2009;57:889–95CrossRefGoogle ScholarPubMed
Phillips, JS, Haggard, M, Yung, M. A new health-related quality of life measure for active chronic otitis media (COMQ-12): development and initial validation. Otol Neurotol 2014;35:454–8CrossRefGoogle ScholarPubMed
Bächinger, D, Röösli, C, Ditzen, B, Huber, AM. Development and validation of the Zurich chronic middle ear inventory (ZCMEI-21): an electronic questionnaire for assessing quality of life in patients with chronic otitis media. Eur Arch Otorhinolaryngol 2016;273:3073–81CrossRefGoogle ScholarPubMed
Kim, H-J, Lee, H-J, An, S-Y, Sim, S, Park, B, Kim, SW et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One 2015;10:e0127578CrossRefGoogle ScholarPubMed
Hiller, W, Goebel, G. Factors influencing tinnitus loudness and annoyance. Arch Otolaryngol Head Neck Surg 2006;132:1323–30CrossRefGoogle ScholarPubMed
Phillips, JS, Yung, MW, Nunney, I, Doruk, C, Kara, H, Kong, T et al. Multinational appraisal of the Chronic Otitis Media Questionnaire 12 (COMQ-12). Otol Neurotol 2020;42:e45–9CrossRefGoogle Scholar
Fonseca, ACO, Ramos, P, Balsalobre, FA, Freitas, EL, Phillips, JS, Yung, MW et al. Validation of a Portuguese version of the health-related quality of life measure for active chronic otitis media (COMQ-12). Braz J Otorhinolaryngol 2018;84:708–12CrossRefGoogle ScholarPubMed
Quaranta, N, De Robertis, V, Milella, C, Pontrelli, M, Greco, A, Fiorella, ML et al. Cross-cultural adaption and validation of the Chronic Otitis Media Questionnaire 12 (COMQ-12) in the Italian language. Eur Arch Otorhinolaryngol 2019;276:3027–33CrossRefGoogle ScholarPubMed
Doruk, C, Çelik, M, Kara, H, Polat, B, Güldiken, Y, Orhan, KS. Turkish translation and validation of Chronic Otitis Media Questionnaire-12. Turk Arch Otorhinolaryngol 2019;57:24–9CrossRefGoogle ScholarPubMed
Celis-Aguilar, E, Medina-Cabrera, CA, Torrontegui-Zazueta, LA, Núñez-Millán, BX, García-Valle, CG, Ochoa-Miranda, CA. Adaptation and validation of the chronic otitis media questionnaire 12 (COMQ-12) in the Mexican Spanish language (COMQ-12-Mx). Acta Otolaryngologica 2020;140:450–5CrossRefGoogle ScholarPubMed
Baba, S, Yagi, T, Fujikura, T. Subjective evaluation and overall satisfaction after tympanoplasty for chronic simple suppurative otitis media. J Nippon Med Sch 2004;71:1724CrossRefGoogle ScholarPubMed
Guo, P, Sun, W, Wang, W. Prognostic and influencing factors of tinnitus in chronic otitis media after tympanoplasty. Eur Arch Otorhinolaryngol 2018;275:3945CrossRefGoogle ScholarPubMed
Kim, HC, Jang, CH, Kim, YY, Seong, JY, Kang, SH, Cho, YB. Role of preoperative air-bone gap in tinnitus outcome after tympanoplasty for chronic otitis media with tinnitus. Braz J Otorhinolaryngol 2018;84:173–7CrossRefGoogle ScholarPubMed
Lima, A da S, Sanchez, TG, Bonadia Moraes, MF, Batezati Alves, SC, Bento, RF. The effect of timpanoplasty on tinnitus in patients with conductive hearing loss: a six month follow-up. Braz J Otorhinolaryngol 2007;73:384–9CrossRefGoogle ScholarPubMed
Habesoglu, M, Habesoglu, TE, Karatas, C, Tosun, A, Gursel, AO, Oysu, C. Is there any predictor for tinnitus outcome in different types of otologic surgery? Eur Arch Otorhinolaryngol 2013;270:2225–9CrossRefGoogle ScholarPubMed
Mittal, R, Lisi, CV, Gerring, R, Mittal, J, Mathee, K, Narasimhan, G et al. Current concepts in the pathogenesis and treatment of chronic suppurative otitis media. J Med Microbiol 2015;64:1103–16CrossRefGoogle ScholarPubMed
Erkorkmaz, U, Yilmaz, MS, Guven, M, Kaymaz, R. Determination of factors that impact patient satisfaction following tympanoplasty. Int Adv Otol 2015;10:264–9CrossRefGoogle Scholar
Phillips, JS, Haggard, M, Spencer, H, Yung, M. The Chronic Otitis Media Benefit Inventory (COMBI): development and validation of a dynamic quality of life questionnaire for chronic ear disease. Otol Neurotol 2017;38:701–7CrossRefGoogle ScholarPubMed
Stouffer, JL, Tyler, RS. Characterization of tinnitus by tinnitus patients. J Speech Hear Disord 1990;55:439–53CrossRefGoogle ScholarPubMed
Bhatt, JM, Lin, HW, Bhattacharyya, N. Tinnitus epidemiology: prevalence, severity, exposures and treatment patterns in the United States. JAMA Otolaryngol Head Neck Surg 2016;142:959–65CrossRefGoogle ScholarPubMed
Otoya-Tono, AM, Pérez-Herrera, LC, Peñaranda, D, Moreno-López, S, Sánchez-Pedraza, R, García, JM et al. Validation of a Spanish version of the health-related quality of life (HRQoL) measure for Chronic Otitis Media (COMQ-12). Health Qual Life Outcomes 2020;18:362CrossRefGoogle ScholarPubMed
Kennedy, V, Wilson, C, Stephens, D. Quality of life and tinnitus. Audiological Medicine 2004;2:2940CrossRefGoogle Scholar
Cordeiro, FP, Monsanto, R da C, Kasemodel, ALP, Gondra, L de A, Penido, N de O. Extended high-frequency hearing loss following the first episode of otitis media. Laryngoscope 2018;128:2879–84CrossRefGoogle ScholarPubMed
Hunter, LL, Margolis, RH, Rykken, JR, Le, CT, Daly, KA, Giebink, GS. High frequency hearing loss associated with otitis media. Ear Hear 1996;17:111CrossRefGoogle ScholarPubMed
Margolis, RH, Saly, GL, Hunter, LL. High-frequency hearing loss and wideband middle ear impedance in children with otitis media histories. Ear Hear 2000;21:206–11CrossRefGoogle ScholarPubMed
Park, JH, Park, SJ, Kim, YH, Park, M-H. Sensorineural hearing loss: a complication of acute otitis media in adults. Eur Arch Otorhinolaryngol 2014;271:1879–84CrossRefGoogle ScholarPubMed
Schachern, PA, Paparella, MM, Goycoolea, MV, Duvall, AJ, Choo, YB. The permeability of the round window membrane during otitis media. Arch Otolaryngol Head Neck Surg 1987;113:625–9CrossRefGoogle ScholarPubMed
Engel, F, Blatz, R, Kellner, J, Palmer, M, Weller, U, Bhadki, S. Breakdown of the round window membrane permeability barrier evoked by streptolysin O: possible etiologic role in development of sensorineural hearing loss in acute otitis media. Infect Immun 1995;63:1305–10CrossRefGoogle ScholarPubMed
Yang, CW, Jung, J, Kim, SH, Byun, JY, Park, MS, Yeo, SG. Comparison of clinical characteristics in patients with bilateral and unilateral tinnitus. Acta Otolaryngol 2015;135:1128–31Google ScholarPubMed