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Analysis of the prognostic significance of lymph node related characteristics in papillary thyroid carcinoma patients presenting with pre- or intra-operative evidence of cervical lymph node metastases

Published online by Cambridge University Press:  17 March 2014

E Soudry ,
O Hilly ,
M Preis ,
T Hadar ,
K Segal ,
G Bachar  and
R Feinmesser
E Soudry
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel Sackler School of Medicine, Tel Aviv University, Israel
O Hilly
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel
M Preis
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel Sackler School of Medicine, Tel Aviv University, Israel
T Hadar
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel Sackler School of Medicine, Tel Aviv University, Israel
K Segal
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel Sackler School of Medicine, Tel Aviv University, Israel
G Bachar
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel Sackler School of Medicine, Tel Aviv University, Israel
R Feinmesser*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel Sackler School of Medicine, Tel Aviv University, Israel
*
Address for correspondence: Dr R Feinmesser, Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Beilinson Campus, Petah Tiqwa 49100, Israel Fax: +972 3 937 6467 E-mail: [email protected]
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Abstract

Objective:

To identify the prognostic significance of specific lymph node related characteristics for disease persistence and recurrence in patients with pre- or intra-operative evidence of neck metastases and no other risk factors.

Method and results

Sixty-eight patients were identified; 50 per cent had persistent or recurrent disease. All underwent the same treatment strategy. There were no statistically significant differences in any of the patient- or tumour-related parameters when patients with and without persistence or recurrence were compared. Patients with recurrent or persistent disease had significantly larger (>3 cm) metastatic lymph nodes, but there were no differences regarding other lymph node related parameters (i.e. number, extracapsular extension, number of lymph nodes with extracapsular extension, and central vs lateral neck location). On multivariate analysis, however, none of the parameters were predictive of persistent or recurrent disease.

Conclusion:

In papillary thyroid carcinoma patients with no other risk factors, pre- or intra-operative evidence of cervical metastases was associated with a very high rate of disease persistence or recurrence. Specific lymph node characteristics were not shown to have prognostic significance.

Keywords

Thyroid NeoplasmsPapillary Thyroid CarcinomaNeoplasm MetastasesLymphadenopathyPrognosisPathology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 3 , March 2014 , pp. 284 - 288
Copyright
Copyright © JLO (1984) Limited 2014 

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