Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-20T11:22:44.112Z Has data issue: false hasContentIssue false
  • English
  • Français

Age-related hearing loss and mild cognitive impairment: a meta-analysis and systematic review of population-based studies

Part of: JLO Editors' Choice Papers 2022

Published online by Cambridge University Press:  13 December 2021

K Lau ,
P A Dimitriadis ,
C Mitchell ,
M Martyn-St-James ,
D Hind  and
J Ray
K Lau*
Affiliation:
Department of Otolaryngology, Sheffield Teaching Hospitals, Sheffield, UK
P A Dimitriadis
Affiliation:
Department of Otolaryngology, Sheffield Teaching Hospitals, Sheffield, UK
C Mitchell
Affiliation:
Academic Unit of Primary Medical Care, Northern General Hospital, Sheffield, UK
M Martyn-St-James
Affiliation:
Health Economics and Decisions Science, School of Health and Related Research, University of Sheffield, UK
D Hind
Affiliation:
Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, UK
J Ray
Affiliation:
Department of Otolaryngology, Sheffield Teaching Hospitals, Sheffield, UK
*
Author for correspondence: Dr Kimberley Lau, Department of Otolaryngology, Sheffield Teaching Hospitals, Glossop Rd, Broomhall, Sheffield S10 2JF, UK E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

The aim of this study was to identify any relationship between hearing loss and mild cognitive impairment.

Method

This was a systematic review and meta-analysis of randomised controlled trials conducted using Medline and the Cochrane Library up to 24 June 2020. Prospective, cohort and cross-sectional, and observational studies that reported on the relationship between mild cognitive impairment and hearing loss were included.

Results

A total of 34 studies reporting data on 48 017 participants were included. Twenty-three studies observed a significant association between hearing loss and mild cognitive impairment. The pooled risk ratio across all studies of prevalence of mild cognitive impairment in people with hearing loss was 1.44 (random-effects; 95 per cent CI = 1.27–1.64; p < 0.00001; I2 = 0 per cent). Significantly more people with mild cognitive impairment had peripheral hearing loss compared with those without (risk ratio, 1.40 random-effects; 95 per cent CI = 1.10–1.77; p = 0.005; I2 = 0 per cent). When the incidence was studied, significantly more people with peripheral hearing loss had mild cognitive impairment compared with those without (risk ratio = 2.06 random-effects; 95 per cent CI = 1.35–3.15; p = 0.0008; I2 = 97 per cent); however; a high level of statistical heterogeneity was evident.

Conclusion

Most of the studies included in this systematic review observed a significant association between hearing loss and mild cognitive impairment.

Keywords

Hearing LossMild Cognitive ImpairmentDementiaPresbycusis
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 2 , February 2022 , pp. 103 - 118
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr K Lau takes responsibility for the integrity of the content of the paper

References

WHO. Millions of people in the world have hearing loss that can be treated or prevented. 2013. In: http://www.who.int/pbd/deafness/news/Millionslivewithhearingloss.pdf [18 August 2020]Google Scholar
Davis, A, McMahon, CM, Pichora-Fuller, KM, Russ, S, Lin, F, Olusanya, BO et al. Aging and hearing health: the life-course approach. Gerontologist 2016;56:S256–67Google ScholarPubMed
Gates, GA, Mills, JH. Presbycusis. Lancet 2005;366:1111–20CrossRefGoogle ScholarPubMed
Heine, C, Browning, CJ. Communication and psychosocial consequences of sensory loss in older adults: overview and rehabilitation directions. Disabil Rehabil 2002;24:763–73CrossRefGoogle ScholarPubMed
Dimitriadis, PA, Vlastarakos, PV, Nikolopoulos, TP. Treatment of Sensorineural Hearing Loss: Contemporary Rehabilitation and Future Prospects. New York: Nova Biomed Books, 2011;101–37Google Scholar
Lin, FR, Albert, M. Hearing loss and dementia – who is listening? Aging Ment Health 2014;18:671–310.1080/13607863.2014.915924CrossRefGoogle ScholarPubMed
Uhlmann, RF, Larson, EB, Rees, TS, Koepsell, TD, Duckert, LG. Relationship of hearing impairment to dementia and cognitive dysfunction in older adults. JAMA J Am Med Assoc 1989;261:1916–9CrossRefGoogle ScholarPubMed
Hong, T, Mitchell, P, Burlutsky, G, Liew, G, Wang, JJ. Visual impairment, hearing loss and cognitive function in an older population: longitudinal findings from the Blue Mountains Eye Study. PLoS One 2016;11:e0147646CrossRefGoogle Scholar
Gennis, V, Garry, PJ, Haaland, KY, Yeo, RA, Goodwin, JS. Hearing and cognition in the elderly: new findings and a review of the literature. Arch Intern Med 1991;151:2259–64CrossRefGoogle Scholar
Livingston, G, Sommerlad, A, Orgeta, V, Costafreda, SG, Huntley, J, Ames, D et al. The Lancet international commission on dementia prevention and care. Lancet 2017;390:2673–734CrossRefGoogle Scholar
DeCarli, C. Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment. Lancet Neurol 2003;2:15–21CrossRefGoogle Scholar
Petersen, RC, Smith, GE, Waring, SC, Ivnik, RJ, Tangalos, EG, Kokmen, E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56:303–8CrossRefGoogle ScholarPubMed
Levey, A, Lah, J, Goldstein, F, Steenland, K, Bliwise, D. Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease. Clin Ther 2006;28:991–1001CrossRefGoogle ScholarPubMed
Petersen, RC, Stevens, JC, Ganguli, M, Tangalos, EG, Cummings, JL, DeKosky, ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56:1133–42CrossRefGoogle ScholarPubMed
Gates, GA. Central presbycusis: an emerging view. Otolaryngol Neck Surg 2012;147:1–2CrossRefGoogle Scholar
PRISMA. Transparent Reporting of Systematic Reviews and Meta-analysis. 2015. In: http://www.prisma-statement.org/Extensions/Protocols [18 August 2021]Google Scholar
Wells, G, Shea, B, O'Connell, D, Peterson, J, Welsch, V, Losos, M et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. In: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp [18 August 2020]Google Scholar
Villeneuve, A, Hommet, C, Aussedat, C, Lescanne, E, Reffet, K, Bakhos, D. Audiometric evaluation in patients with Alzheimer's disease. Eur Arch Otorhinolaryngol 2017;274:151–7CrossRefGoogle ScholarPubMed
Schnitker, LM, Beattie, ERA, Martin-Khan, M, Burkett, E, Gray, LC. Characteristics of older people with cognitive impairment attending emergency departments: a descriptive study. Australas Emerg Nurs J 2016;19:118–26CrossRefGoogle ScholarPubMed
Schubert, CR, Fischer, ME, Pinto, AA, Klein, BEK, Klein, R, Tweed, TS et al. Sensory impairments and risk of mortality in older adults. Journals Gerontol A Biol Sci Med Sci 2017;72:710–5Google ScholarPubMed
Dotchin, CL, Paddick, SM, Gray, WK, Kisoli, A, Orega, G, Longdon, AR et al. The association between disability and cognitive impairment in an elderly Tanzanian population. J Epidemiol Glob Health 2015;5:57–64CrossRefGoogle Scholar
Wong, LLN, Yu, JKY, Chan, SS, Tong, MCF. Screening of cognitive function and hearing impairment in older adults: a preliminary study. Biomed Res Int 2014:867852Google ScholarPubMed
Moradi, S, Lidestam, B, Hällgren, M, Rönnberg, J. Gated auditory speech perception in elderly hearing aid users and elderly normal-hearing individuals: effects of hearing impairment and cognitive capacity. Trends Hear 2014;18:2331216514545406Google ScholarPubMed
Pronk, M, Deeg, DJH, Festen, JM, Twisk, JW, Smits, C, Comijs, HC et al. Decline in older persons’ ability to recognize speech in noise: the influence of demographic, health-related, environmental, and cognitive factors. Ear Hear 2013;34:722–32CrossRefGoogle ScholarPubMed
Clipboard. Hearing loss accelerates brain function decline in older adults. Home Heal Nurse 2013;31:240Google Scholar
Helvik, AS, Selbæk, G, Engedal, K. Cognitive decline one year after hospitalization in older adults without dementia. Dement Geriatr Cogn Disord 2012;34:198–205CrossRefGoogle ScholarPubMed
Gurina, NA, Frolova, EV, Degryse, JM. A roadmap of aging in Russia: the prevalence of frailty in community-dwelling older adults in the St. Petersburg District-The “crystal” study. J Am Geriatr Soc 2011;59:980–8CrossRefGoogle Scholar
Srinivasan, K, Vaz, M, Thomas, T. Prevalence of health related disability among community dwelling urban elderly from middle socioeconomic strata in Bangaluru, India. Indian J Med Res 2010;131:515–21Google ScholarPubMed
Munshi, M, Grande, L, Hayes, M, Ayres, D, Suhl, E, Capelson, R et al. Cognitive dysfunction is associated with poor diabetes control in older adults. Diabetes Care 2006;29:1794–9CrossRefGoogle ScholarPubMed
Riello, R, Geroldi, C, Zanetti, O, Vergani, C, Frisoni, GB. Differential associations of Head and Body Symptoms with depression and physical comorbidity in patients with cognitive impairment. Int J Geriatr Psychiatry 2004;19:209–15CrossRefGoogle ScholarPubMed
Allen, NH, Burns, A, Newton, V, Hickson, F, Ramsden, R, Rogers, J et al. The effects of improving hearing in dementia. Age Ageing 2003;32:189–93CrossRefGoogle ScholarPubMed
Uhlmann, RF, Larson, EB, Koepsell, TD. Hearing impairment and cognitive decline in senile dementia of the Alzheimer's type. J Am Geriatr Soc 1986;34:207–10CrossRefGoogle ScholarPubMed
Daggett, V, Bakas, T, Murray, L, Woodward-Hagg, H, Williams, JG, Maddox, K et al. Feasibility and satisfaction with the VETeranS Compensate, Adapt, REintegrate (VETS-CARE) intervention. Brain Injury 2014;28:554–5Google Scholar
Lin, FR, Albert, MS, Alonso, A, Bangdiwala, S, Chisolm, T, Coker, L et al. Results from the ACHIEVE-P study: a pilot study for a randomized controlled trial to determine if hearing loss treatment can reduce the risk of cognitive decline in older adults. Alzheimer's Dement 2016;7:829–30Google Scholar
Yu, WC, Chou, MY, Peng, LN, Lin, Y Te, Liang, CK, Chen, LK. Synergistic effects of cognitive impairment on physical disability in all-cause mortality among men aged 80 years and over: Results from longitudinal older veterans study. PLoS One 2017;12:1–13Google ScholarPubMed
Ray, J, Popli, G, Fell, G. Association of cognition and age-related hearing impairment in the English Longitudinal Study of Ageing. JAMA Otolaryngol Head Neck Surg 2018;144:876–82CrossRefGoogle ScholarPubMed
Murphy, CFB, Rabelo, CM, Silagi, ML, Mansur, LL, Bamiou, DE, Schochat, E. Auditory processing performance of the middle-aged and elderly: auditory or cognitive decline? J Am Acad Audiol 2018;29:5–14Google ScholarPubMed
Davidson, JGS, Guthrie, DM. Older adults with a combination of vision and hearing impairment experience higher rates of cognitive impairment, functional dependence, and worse outcomes across a set of quality indicators. J Aging Health 2019;31:85–108CrossRefGoogle ScholarPubMed
Maharani, A, Dawes, P, Nazroo, J, Tampubolon, G, Pendleton, N. Visual and hearing impairments are associated with cognitive decline in older people. Age Ageing 2018;47:575–81CrossRefGoogle ScholarPubMed
Schubert, CR, Cruickshanks, KJ, Fischer, ME, Pinto, AA, Chen, Y, Huang, GH et al. Sensorineural impairments, cardiovascular risk factors, and 10-year incidence of cognitive impairment and decline in midlife: The Beaver Dam Offspring Study. J Gerontol A Biol Sci Med Sci 2019;74:1786–92CrossRefGoogle ScholarPubMed
Yu, R, Woo, J. Cognitive assessment of older people: do sensory function and frailty matter? Int J Environ Res Public Health 2019;16:662Google ScholarPubMed
Vaccaro, R, Zaccaria, D, Colombo, M, Abbondanza, S, Guaita, A. Adverse effect of self-reported hearing disability in elderly Italians: results from the InveCe.Ab study. Maturitas 2019;121:35–40CrossRefGoogle ScholarPubMed
Curhan, SG, Willett, WC, Grodstein, F, Curhan, GC. Longitudinal study of hearing loss and subjective cognitive function decline in men. Alzheimer's Dement 2019;15:525–33CrossRefGoogle ScholarPubMed
Gallagher, D, Kiss, A, Lanctot, KL, Herrmann, N. Toward prevention of mild cognitive impairment in older adults with depression: an observational study of potentially modifiable risk factors. J Clin Psychiatry 2018;80:1–14CrossRefGoogle ScholarPubMed
Deal, JA, Betz, J, Yaffe, K, Harris, T, Purchase-Helzner, E, Satterfield, S et al. Hearing impairment and incident dementia and cognitive decline in older adults: the health ABC study. J Gerontol A Biol Sci Med Sci 2017;72:703–9Google ScholarPubMed
Yang, F, Gu, D. Predictability of frailty index and its components on mortality in older adults in China. BMC Geriatr 2016;16:1–910.1186/s12877-016-0317-zCrossRefGoogle ScholarPubMed
Fischer, ME, Cruickshanks, KJ, Schubert, CR, Pinto, AA, Carlsson, CM, Klein, BEK et al. Age-related sensory impairments and risk of cognitive impairment. J Am Geriatr Soc 2016;64:1981–7CrossRefGoogle ScholarPubMed
Gurgel, RK, Ward, PD, Schwartz, S, Norton, MC, Foster, NL, Tschanz, JT. Relationship of hearing loss and dementia: a prospective, population-based study. Otol Neurotol 2014;35:775–81CrossRefGoogle ScholarPubMed
Gates, GA, Cobb, JL, Linn, RT, Rees, T, Wolf, PA, D'Agostino, RB. Central auditory dysfunction, cognitive dysfunction, and dementia in older people. Arch Otolaryngol Head Neck Surg 1996;122:161–7CrossRefGoogle ScholarPubMed
Han, R, Tang, Z, Ma, L. Related factors of cognitive impairment in community-dwelling older adults in Beijing Longitudinal Study of Aging. Aging Clin Exp Res 2019;31:95–100CrossRefGoogle ScholarPubMed
Heward, J, Stone, L, Paddick, SM, Mkenda, S, Gray, WK, Dotchin, CL et al. A longitudinal study of cognitive decline in rural Tanzania: rates and potentially modifiable risk factors. Int Psychogeriatrics 2018;30:1333–43CrossRefGoogle ScholarPubMed
MacDonald, SWS, Keller, CJC, Brewster, PWH, Dixon, RA. Contrasting olfaction, vision, and audition as predictors of cognitive change and impairment in non-demented older adults. Neuropsychology 2018;32:450–60CrossRefGoogle ScholarPubMed
Iliadou, V, Bamiou, DE, Sidiras, C, Moschopoulos, NP, Tsolaki, M, Nimatoudis, I et al. The use of the gaps-in-noise test as an index of the enhanced left temporal cortical thinning associated with the transition between mild cognitive impairment and Alzheimer's disease. J Am Acad Audiol 2017;28:463–71Google ScholarPubMed
Bruckmann, M, Pinheiro, MMC. Effects of hearing and cognitive impairment in sentence recognition. Codas 2016;28:338–44CrossRefGoogle ScholarPubMed
Bucks, RS, Dunlop, PD, Taljaard, DS, Brennan-Jones, CG, Hunter, M, Wesnes, K et al. Hearing loss and cognition in the Busselton Baby Boomer cohort: an epidemiological study. Laryngoscope 2016;126:2367–75CrossRefGoogle ScholarPubMed
Lister, JJ, Harrison Bush, AL, Andel, R, Matthews, C, Morgan, D, Edwards, JD. Cortical auditory evoked responses of older adults with and without probable mild cognitive impairment. Clin Neurophysiol 2016;127:1279–87CrossRefGoogle ScholarPubMed
Deal, JA, Sharrett, AR, Albert, MS, Coresh, J, Mosley, TH, Knopman, D et al. Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study. Am J Epidemiol 2015;181:680–90Google ScholarPubMed
Zhang, G-Y, Yang, M, Liu, B, Huang, Z-C, Chen, H, Zhang, P-P et al. Changes in the default mode networks of individuals with long-term unilateral sensorineural hearing loss. Neuroscience 2015;285:333–42CrossRefGoogle ScholarPubMed
Quaranta, N, Coppola, F, Casulli, M, Barulli, O, Lanza, F, Tortelli, R et al. The prevalence of peripheral and central hearing impairment and its relation to cognition in older adults. Audiol Neurotol 2014;19:10–4CrossRefGoogle ScholarPubMed
Lin, FR, Ferrucci, L, Metter, EJ, An, Y, Zonderman, AB, Resnick, SM. Hearing loss and cognition in the Baltimore Longitudinal Study of Aging. Neuropsychology 2011;25:763CrossRefGoogle ScholarPubMed
Rahman, TTA, Mohamed, ST, Albanouby, MH, Bekhet, HF. Central auditory processing in elderly with mild cognitive impairment. Geriatr Gerontol Int 2011;11:304–8CrossRefGoogle ScholarPubMed
Idrizbegovic, E, Hederstierna, C, Dahlquist, M, Kämpfe Nordström, C, Jelic, V, Rosenhall, U. Central auditory function in early Alzheimer's disease and in mild cognitive impairment. Age Ageing 2011;40:249–54CrossRefGoogle ScholarPubMed
Gates, GA, Gibbons, LE, McCurry, SM, Crane, PK, Feeney, MP, Larson, EB. Executive dysfunction and presbycusis in older persons with and without memory loss and dementia. Cogn Behav Neurol 2010;23:218–23CrossRefGoogle ScholarPubMed
Benito-León, J, Mitchell, AJ, Vega, S, Bermejo-Pareja, F. A population-based study of cognitive function in older people with subjective memory complaints. J Alzheimer's Dis 2010;22:159–70CrossRefGoogle ScholarPubMed
Gates, GA, Anderson, ML, Feeney, MP, McCurry, SM, Larson, EB. Central auditory dysfunction in older persons with memory impairment or Alzheimer dementia. Arch Otolaryngol Head Neck Surg 2008;134:771–7CrossRefGoogle ScholarPubMed
Tay, T, Kifley, A, Lindley, R, Landau, P, Ingham, N, Mitchell, P et al. Are sensory and cognitive declines associated in older persons seeking aged care services? Findings from a pilot study. Ann Med Singapore 2006;35:254Google Scholar
Van Boxtel, MPJ, Beijsterveldt van, CEM, Houx, PJ, Anteunis, LJ, Metsemakers, JF, Jolles, J. Mild hearing impairment can reduce verbal memory performance in a healthy adult population. J Clin Exp Neuropsychol 2000;22:147–54CrossRefGoogle Scholar
Frisina, DR, Frisina, RD. Speech recognition in noise and presbycusis: relations to possible neural mechanisms. Hear Res 1997;106:95–104CrossRefGoogle ScholarPubMed
Gates, GA, Karzon, RK, Garcia, P, Peterein, J, Storandt, M, Morris, JC et al. Auditory dysfunction in aging and senile dementia of the Alzheimer's type. Arch Neurol 1995;52:626–34CrossRefGoogle ScholarPubMed
Strouse, AL, Hall, JW, Burger, MC. Central auditory processing in alzheimer's disease. Ear Hear 1995;16:230–810.1097/00003446-199504000-00010CrossRefGoogle ScholarPubMed
DeVore, PA. Prevalence of olfactory dysfunction, hearing deficit, and cognitive dysfunction among elderly patients in a suburban family practice. South Med J 1992;85:894–6Google Scholar
Heywood, R, Gao, Q, Nyunt, MSZ, Feng, L, Chong, MS, Lim, WS et al. Hearing loss and risk of mild cognitive impairment and dementia: findings from the Singapore Longitudinal Ageing Study. Dement Geriatr Cogn Disord 2017;43:259–68CrossRefGoogle ScholarPubMed
WHO. Prevention of Blindness and Deafness: Grades of Hearing Impairment. In: http://www.who.int/pbd/deafness/hearing_impairment_grades/en/ [18 August 2020]Google Scholar
Folstein, MF, Folstein, SE, McHugh, PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98CrossRefGoogle ScholarPubMed
Nondahl, DM, Cruickshanks, KJ, Wiley, TL, Tweed, TS, Klein, R, Klein, BEK. Accuracy of self-reported hearing loss. Audiology 1998;37:295–301CrossRefGoogle ScholarPubMed
Sindhusake, D, Mitchell, P, Smith, W, Golding, M, Newall, P, Hartley, D et al. Validation of self-reported hearing loss. The Blue Mountains hearing study. Int J Epidemiol 2001;30:1371–8CrossRefGoogle ScholarPubMed
Tun, PA, McCoy, S, Wingfield, A. Aging, hearing acuity, and the attentional costs of effortful listening. Psychol Aging 2009;24:761CrossRefGoogle ScholarPubMed
Pichora-Fuller, MK, Schneider, BA, Daneman, M. How young and old adults listen to and remember speech in noise. J Acoust Soc Am 1995;97:593–608CrossRefGoogle Scholar
Langa, KM, Levine, DA. The diagnosis and management of mild cognitive impairment: a clinical review. JAMA 2014;312:2551–61CrossRefGoogle ScholarPubMed