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Aesthesioneuroblastoma

Published online by Cambridge University Press:  29 June 2007

Venkata N. Koka ,
Morbize Julieron ,
Jean Bourhis ,
Francois Janot ,
Anne Marie Le Ridant ,
Patrick Marandas ,
Bernard Luboinski  and
Guy Schwaab
Venkata N. Koka
Affiliation:
Department of Head and Neck Surgery, Institut Gustave Roussy, 94805 Villejuif, France.
Morbize Julieron
Affiliation:
Department of Head and Neck Surgery, Institut Gustave Roussy, 94805 Villejuif, France.
Jean Bourhis
Affiliation:
Department of Head and Neck Surgery, Institut Gustave Roussy, 94805 Villejuif, France.
Francois Janot
Affiliation:
Department of Head and Neck Surgery, Institut Gustave Roussy, 94805 Villejuif, France.
Anne Marie Le Ridant
Affiliation:
Department of Head and Neck Surgery, Institut Gustave Roussy, 94805 Villejuif, France.
Patrick Marandas
Affiliation:
Department of Head and Neck Surgery, Institut Gustave Roussy, 94805 Villejuif, France.
Bernard Luboinski
Affiliation:
Department of Head and Neck Surgery, Institut Gustave Roussy, 94805 Villejuif, France.
Guy Schwaab*
Affiliation:
Department of Head and Neck Surgery, Institut Gustave Roussy, 94805 Villejuif, France.
*
Address for correspondence: Dr Guy Schwaab, M.D., Chief of Unit-Head and Neck Surgery, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif, France. Fax: 331 42115273
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Abstract

Forty patients were treated or followed up for aesthesioneuroblastoma between 1980 and 1995 at Institut Gustave Roussy, France. There were three T1; seven T2, 15 T3 and 15 T4 lesions. The cervical metastatic rate at presentation was 18 per cent. Distant metastases were detected by bone marrow biopsy and bone scan in three patients at presentation. Treatment modalities included surgery alone in eight patients, radiotherapy alone in three patients, combined modality surgery plus radiotherapy in 11 patients, chemotherapy alone in two patients, chemotherapy plus radiotherapy in 10 patients, and multimodality therapy chemotherapy plus surgery plus radiotherapy in six patients.

The five-year survival rate was 51 per cent. Multimodality treatment offered better survival (63 per cent at five years) and disease-free interval (54 months). Overall local, regional, and distant failure rates were 58 per cent, 15 per cent and 40 per cent respectively. Distant metastases commonly occurred in bone (82 per cent). Cervical metastasis was an unfavourable prognostic indicator (0 per cent survival at two years).

In conclusion, aesthesioneuroblastoma is sensitive to chemotherapy and radiotherapy. Multimodality therapy should be used initially.

Keywords

NeuroblastomaOlfactory mucosaSurgery, operativeRadiotherapyChemotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 7 , July 1998 , pp. 628 - 633
Copyright
Copyright © JLO (1984) Limited 1998

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