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Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1

Published online by Cambridge University Press:  20 January 2009

S Suzuki ,
K Hanata ,
H Nanjo  and
K Ishikawa
S Suzuki*
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Akita University School of Medicine, Akita, Japan
K Hanata
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Akita University School of Medicine, Akita, Japan
H Nanjo
Affiliation:
Department of Pathology, Akita University School of Medicine, Akita, Japan
K Ishikawa
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Akita University School of Medicine, Akita, Japan
*
Address for correspondence: Dr Shinsuke Suzuki, Department of Otolaryngology and Head and Neck Surgery, Akita University School of Medicine, Akita, Akita 010-0851, Japan. Fax: +81 (018) 836 2622 E-mail: [email protected]
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Abstract

Background:

Adenosquamous carcinoma is a very rare tumour which is characterised pathologically by the simultaneous presence of distinct areas of adenocarcinoma and squamous cell carcinoma. Generally, adenosquamous carcinoma has an aggressive clinical course and is associated with a poor prognosis. Most cases have been treated by surgery alone or combined with radiotherapy. Chemotherapy is rarely used in treating adenosquamous carcinoma, and it has been difficult to establish treatment guidelines due to the paucity of cases.

Case:

We report a case of adenosquamous carcinoma which arose in the maxillary sinus of a 77-year-old man. Despite surgical treatment and chemoradiotherapy to the primary site, he developed bilateral neck metastases after the surgery. The patient was treated with S-1, a novel oral fluoropyrimidine anticancer agent, with a complete (albeit finite) response.

Conclusion:

This report presents the aggressive character of adenosquamous carcinoma and the possible role of S-1 in the treatment of this uncommon neoplasm.

Keywords

Head and Neck NeoplasmsMaxillary NeoplasmsAdenosquamous CarcinomaDrug Therapy
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 11 , November 2009 , pp. 1271 - 1275
Copyright
Copyright © JLO (1984) Limited 2009

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