Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-13T01:04:23.604Z Has data issue: false hasContentIssue false
  • English
  • Français

Adenoid mast cells and their role in the pathogenesis of otitis media with effusion

Published online by Cambridge University Press:  14 March 2006

B Abdullah ,
S Hassan ,
D Sidek  and
H Jaafar
B Abdullah
Affiliation:
Department of Otorhinolaryngology–Head and Neck Surgery, Kubang Kerian, Kelantan, Malaysia
S Hassan
Affiliation:
Department of Otorhinolaryngology–Head and Neck Surgery, Kubang Kerian, Kelantan, Malaysia
D Sidek
Affiliation:
Department of Otorhinolaryngology–Head and Neck Surgery, Kubang Kerian, Kelantan, Malaysia
H Jaafar
Affiliation:
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Get access Rights & Permissions [Opens in a new window]

Abstract

Introduction: Otitis media with effusion (OME) is an inflammation of the middle ear in which a collection of liquid is present in the middle-ear space while the tympanic membrane is intact. The association between adenoid inflammation and OME has long been noted but the exact mechanism is still much debated. We studied the role of adenoid mast cells in the causation of OME.

Objective: To study the distribution and role of adenoid mast cells in the causation of OME

Methodology: A cross-sectional, prospective study was carried out in the otorhinolaryngologic clinic, department of otorhinolaryngology (ORL), Science University of Malaysia, from June 1999 to September 2001. A total number of 50 cases were studied. Twenty-five of these patients underwent adenoidectomy, while another 25 patients underwent adenoidectomy and myringotomy with ventilation tube insertion. The adenoid specimens from all patients were examined for the number of adenoid mast cells present, using light microscopy and toluidine blue as the staining agent. The results were analysed using SPSS version 10.0 computer software.

Result: The population of adenoid mast cells in children with OME was significantly greater than that in children without OME (p = 0.000).

Conclusion: The increased number of adenoid mast cells in patients with OME suggests that inflammation may play a role in this condition.

Keywords

AdenoidOtitis Media with EffusionMast Cell, Pathogenesis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 120 , Issue 7 , July 2006 , pp. 556 - 560
Copyright
2006 JLO (1984) Limited

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)