Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-30T23:23:24.588Z Has data issue: false hasContentIssue false
  • English
  • Français

Vestibular evoked myogenic potentials in patients with fibromyalgia syndrome

Published online by Cambridge University Press:  22 February 2010

Y A Bayazit ,
F Celenk ,
A G Gunduz ,
B Gunduz ,
N Ondag  and
J Meray
Y A Bayazit*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey
F Celenk
Affiliation:
Department of Otorhinolaryngology Clinic, Mersin Toros Government Hospital, Ankara, Turkey
A G Gunduz
Affiliation:
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hacettepe University, Ankara, Turkey
B Gunduz
Affiliation:
Department of Audiology, Faculty of Medicine, Gazi University, Ankara, Turkey
N Ondag
Affiliation:
Department of Audiology, Faculty of Medicine, Gazi University, Ankara, Turkey
J Meray
Affiliation:
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Gazi University, Ankara, Turkey
*
Address for correspondence: Dr Yildirim A Bayazit, Department of Otorhinolaryngology, Gazi University Faculty of Medicine, 06500 Besevler, Cankaya, Ankara, Turkey. Tel: +90 312 2026432 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To assess vestibular evoked myogenic potentials in patients with fibromyalgia syndrome.

Methods:

Twenty-four patients with fibromyalgia syndrome (two men and 22 women) and 21 female controls were included in the study. All patients underwent vestibular evoked myogenic potential testing.

Results:

Statistical comparison of fibromyalgia patients with control subjects showed a significant difference with respect to n23 latencies and interpeak latencies (p < 0.05). There was no significant difference in p13 latencies, nor in p13 amplitudes, n23 amplitudes or interpeak amplitudes (p > 0.05).

Conclusions:

Although patients with fibromyalgia syndrome generally have subjective neurotological symptoms, clinical and laboratory assessments usually fail to detect any objective abnormality. However, it is possible to detect abnormalities on vestibular evoked myogenic potential testing in such patients, indicating dysfunction in the vestibulospinal pathway, possibly in the saccule. Elongation of the n23 latency and of the interpeak latency of waves p13–n23, during vestibular evoked myogenic potential testing, may be a useful, objective indicator demonstrating neurotological involvement in fibromyalgia syndrome patients. Future research investigating the mechanisms of this latency elongation may help increase understanding of the pathogenesis of fibromyalgia syndrome.

Keywords

FibromyalgiaVestibular Function TestsVestibular Evoked Myogenic Potential
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 6 , June 2010 , pp. 610 - 615
Copyright
Copyright © JLO (1984) Limited 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Schweinhardt, P, Sauro, KM, Bushnell, MC. Fibromyalgia: a disorder of the brain? Neuroscientist 2008;14:415–21CrossRefGoogle ScholarPubMed
2 Wolfe, F, Smythe, HA, Yunus, MB, Bennett, RM, Bombardier, C, Goldenberg, DL et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990;33:160–72CrossRefGoogle ScholarPubMed
3 Neeck, G. Pathogenic mechanisms of fibromyalgia. Ageing Res Rev 2002;1:243–55CrossRefGoogle ScholarPubMed
4 Ozgocmen, S, Ozyurt, H, Sogut, S, Akyol, O. Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide. Rheumatol Int 2006;26:585–97Google Scholar
5 Gunduz, B, Bayazit, YA, Celenk, F, Saridoğan, C, Guclu, AG, Orcan, E et al. Absence of contralateral suppression of transiently evoked otoacoustic emissions in fibromyalgia syndrome. J Laryngol Otol 2008;122:1047–51CrossRefGoogle ScholarPubMed
6 Clauw, DJ, Crofford, LJ. Chronic widespread pain and fibromyalgia: what we know, and what we need to know. Best Pract Res Clin Rheumatol 2003;17:685–701CrossRefGoogle ScholarPubMed
7 Daoud, KF, Barkhuizen, A. Rheumatic mimics and selected triggers of fibromyalgia. Curr Pain Headache Rep 2002;6:284–8CrossRefGoogle ScholarPubMed
8 Yunus, MB, Khan, MA, Rawlings, KK, Green, JR, Olson, JM, Shah, S. Genetic linkage analysis of multicase families with fibromyalgia syndrome. J Rheumatol 1999;26:408–12Google ScholarPubMed
9 Abeles, AM, Pillinger, MH, Solitar, BM, Abeles, M. Narrative review: the pathophysiology of fibromyalgia. Ann Intern Med 2007;146:726–34CrossRefGoogle ScholarPubMed
10 Yunus, MB. Towards a model of pathophysiology of fibromyalgia: aberrant central pain mechanisms with peripheral modulation. J Rheumatol 1992;19:846–50Google Scholar
11 Staud, R, Rodriguez, ME. Mechanisms of disease: pain in fibromyalgia syndrome. Nat Clin Pract Rheumatol 2006;2:90–8CrossRefGoogle ScholarPubMed
12 Alnigenis, MN, Barland, P. Fibromyalgia syndrome and serotonin. Clin Exp Rheumatol 2001;19:205–10Google ScholarPubMed
13 Russell, IJ, Vaeroy, H, Javors, M, Nyberg, F. Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis. Arthritis Rheum 1992;35:550–6CrossRefGoogle ScholarPubMed
14 Russell, IJ, Orr, MD, Littman, B, Vipraio, GA, Alboukrek, D, Michalek, JE et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheum 1994;37:1593–601CrossRefGoogle ScholarPubMed
15 Crofford, LJ, Pillemer, SR, Kalogeras, KT, Cash, JM, Michelson, D, Kling, MA et al. Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum 1994;37:1583–92CrossRefGoogle ScholarPubMed
16 Mease, P. Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol Suppl 2005;75:6–21Google ScholarPubMed
17 Giesecke, T, Williams, DA, Harris, RE, Cupps, TR, Tian, X, Tian, TX et al. Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. Arthritis Rheum 2003;48:2916–22CrossRefGoogle ScholarPubMed
18 Colebatch, JG. Vestibular evoked potentials. Curr Opin Neurol 2001;14:21–6CrossRefGoogle ScholarPubMed
19 Bayazit, YA, Gürsoy, S, Ozer, E, Karakurum, G, Madenci, E. Neurotologic manifestations of the fibromyalgia syndrome. J Neurol Sci 2002;196:77–80CrossRefGoogle ScholarPubMed
20 Yilmaz, M, Baysal, E, Gunduz, B, Aksu, A, Ensari, N, Meray, J et al. Assessment of the ear and otoacoustic emission findings in fibromyalgia syndrome. Clin Exp Rheumatol 2005;23:701–3Google ScholarPubMed
21 Burckhardt, CS, Clark, SR, Bennett, RM. The fibromyalgia impact questionnaire: development and validation. J Rheumatol 1991;18:728–33Google Scholar
22 McCue, MP, Guinan, JJ Jr. Acoustically responsive fibers in the vestibular nerve of the cat. J Neurosci 1994;14:6058–70Google Scholar
23 McCue, MP, Guinan, JJ Jr. Spontaneous activity and frequency selectivity of acoustically responsive vestibular afferents in the cat. J Neurophysiol 1995;74:1563–72CrossRefGoogle ScholarPubMed
24 Colebatch, JG, Halmagyi, GM. Vestibular evoked potentials in human neck muscles before and after unilateral vestibular deafferentation. Neurology 1992;42:1635–6CrossRefGoogle ScholarPubMed
25 Welgampola, MS, Colebatch, JG. Characteristics and clinical applications of vestibular-evoked myogenic potentials. Neurology 2005;64:1682–8CrossRefGoogle ScholarPubMed
26 Isaradisaikul, S, Strong, DA, Moushey, JM, Gabbard, SA, Ackley, SR, Jenkins, HA. Reliability of vestibular evoked myogenic potentials in healthy subjects. Otol Neurotol 2008;29:542–4CrossRefGoogle ScholarPubMed
27 Robertson, DD, Ireland, DJ. Vestibular evoked myogenic potentials. J Otolaryngol 1995;24:3–8Google ScholarPubMed
28 Lee, SK, Cha, CI, Jung, TS, Park, DC, Yeo, SG. Age-related differences in parameters of vestibular evoked myogenic potentials. Acta Otolaryngol 2008;128:66–72Google Scholar
29 Murofushi, T, Shimizu, K, Takegoshi, H, Cheng, PW. Diagnostic value of prolonged latencies in the vestibular evoked myogenic potential. Arch Otolaryngol Head Neck Surg 2001;127:1069–72Google Scholar
30 Huang, TW, Young, YH, Cheng, PW. An acoustically evoked short latency negative response in profound hearing loss infants. Acta Otolaryngol 2004;124:1022–7Google Scholar
31 Lee, KJ, Kim, MS, Son, EJ, Lim, HJ, Bang, JH, Kang, JG. Usefulness of rectified VEMP. Clin Exp Otorhinolaryngol 2008;1:143–7CrossRefGoogle ScholarPubMed