Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-28T01:19:23.638Z Has data issue: false hasContentIssue false
  • English
  • Français

Systematic review of vestibular disorders related to human immunodeficiency virus and acquired immunodeficiency syndrome

Published online by Cambridge University Press:  05 July 2011

B Heinze ,
D W Swanepoel  and
L M Hofmeyr
B Heinze*
Affiliation:
Department of Communication Pathology, University of Pretoria, Pretoria, South Africa
D W Swanepoel
Affiliation:
Department of Communication Pathology, University of Pretoria, Pretoria, South Africa Callier Center for Communication Disorders, University of Texas at Dallas, USA
L M Hofmeyr
Affiliation:
Department of Otorhinolaryngology, University of Pretoria, Pretoria, South Africa
*
Address for correspondence: Dr Barbara Heinze, Department of Communication Pathology, Private Bag X20, Hatfield, Pretoria, 0028, South Africa Fax: +27 12 420 3517 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Introduction:

Disorders of the auditory and vestibular system are often associated with human immunodeficiency virus infection and acquired immunodeficiency syndrome. However, the extent and nature of these vestibular manifestations are unclear.

Objective:

To systematically review the current peer-reviewed literature on vestibular manifestations and pathology related to human immunodeficiency virus and acquired immunodeficiency syndrome.

Method:

Systematic review of peer-reviewed articles related to vestibular findings in individuals with human immunodeficiency virus infection and acquired immunodeficiency syndrome. Several electronic databases were searched.

Results:

We identified 442 records, reduced to 210 after excluding duplicates and reviews. These were reviewed for relevance to the scope of the study.

Discussion:

We identified only 13 reports investigating vestibular functioning and pathology in individuals affected by human immunodeficiency virus and acquired immunodeficiency syndrome. This condition can affect both the peripheral and central vestibular system, irrespective of age and viral disease stage. Peripheral vestibular involvement may affect up to 50 per cent of patients, and central vestibular involvement may be even more prevalent. Post-mortem studies suggest direct involvement of the entire vestibular system, while opportunistic infections such as oto- and neurosyphilis and encephalitis cause secondary vestibular dysfunction resulting in vertigo, dizziness and imbalance.

Conclusion:

Patients with human immunodeficiency virus and acquired immunodeficiency syndrome should routinely be monitored for vestibular involvement, to minimise functional limitations of quality of life.

Keywords

HIVAcquired Immunodeficiency SyndromeVestibular Function TestsDizzinessVertigoAIDS-Related Opportunistic Infections
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 9 , September 2011 , pp. 881 - 890
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Nwaorgu, O, Kokong, D, Onakoya, P, Adoga, S, Ibekwe, T. Prevalence of human immunodeficiency virus seropositivity in head and neck malignancies in sub-Saharan Africa. Acta Otolaryngol 2007;127:1218–21CrossRefGoogle ScholarPubMed
2Marcusen, DC, Sooy, CD. Otolaryngologic and head and neck manifestations of acquired immunodeficiency syndrome (AIDS). Laryngoscope 1985;95:401–5CrossRefGoogle ScholarPubMed
3Singh, B. Alterations in head and neck cancer occurring in HIV-infected patients: results of a pilot, longitudinal, prospective study. Acta Oncol 1999;38:1047–50CrossRefGoogle ScholarPubMed
4Barzan, L, Tavio, M, Tirelli, U, Comoretto, R. Head and neck manifestations during HIV infection. J Laryngol Otol 1993;107:133–6CrossRefGoogle ScholarPubMed
5Neurotologic manifestations of HIV infection. In: http://www.bcm.edu/oto/grand/32494.html [21 January 2010]Google Scholar
6Somefun, A, Nwawolo, CC, Okeowo, PA, Ogban, LU, Akanmu, AS, Okanny, CC et al. Otorhinolaryngological manifestations of HIV/AIDS in Lagos. Niger Postgrad Med J 2001;8:170–4CrossRefGoogle ScholarPubMed
7Lubbe, DE. HIV and ENT. Continuing Medical Education 2004;22:250–3Google Scholar
8Rey, D, L'Heritier, A, Lang, JM. Severe ototoxicity in a health care worker who received post-exposure prophylaxis with stavudine, lamivudine, and nevirapine after occupational exposure to HIV. Clin Infect Dis 2002;34:417–22CrossRefGoogle Scholar
9Rinaldo, A, Brandwein, MS, Devaney, KO, Ferlito, A. AIDS-related otological lesions. Acta Otolaryngol 2003;123:672–4CrossRefGoogle ScholarPubMed
10Beers, SL, Abramo, TJ. Otitis externa review. Pediatr Emerg Care 2004;20:250–6CrossRefGoogle ScholarPubMed
11Gurney, TA, Murr, A. Otolaryngology manifestations of human immunodeficiency virus infection. Otolaryngol Clin North Am 2003;36:607–24CrossRefGoogle ScholarPubMed
12Stearn, N, Swanepoel, DW. Sensory and neural auditory disorders associated with HIV/AIDS. In: Swanepoel, DW, Louw, B, eds. HIV/AIDS Related Communication, Hearing and Swallowing Disorders. San Diego, Oxford, Brisbane: Plural Publishing, 2010;243–88Google Scholar
13Newton, PJ. The causes of hearing loss in HIV infection. Community Ear and Hearing Health 2006;3:11–14CrossRefGoogle Scholar
14Jastreboff, PJ, Hazell, JWP. Tinnitus Retraining Therapy: Implementing the Neurophysiological Model. Cambridge: Cambridge University Press, 2004CrossRefGoogle Scholar
15Bankaitis, AE, Keith, RW. Audiological changes associated with HIV infection. Ear Nose Throat J 1995;74:353–8CrossRefGoogle ScholarPubMed
16Reyes-Contreras, L, Silva-Rojas, A, Ysunza-Rivera, A, Jimenez-Ruiz, G, Berruecos-Villalobos, P, Romo-Gutierrez, G. Brainstem auditory evoked response in HIV-infected patients with and without AIDS. Arch Med Res 2002;33:25–8CrossRefGoogle ScholarPubMed
17Zuniga, J. Communication disorders and HIV disease. J Int Assoc Physicians AIDS Care 1999;5:16–23Google ScholarPubMed
18Teggi, R, Ceserani, N, Luce, FL, Lazzarin, A, Bussi, M. Otoneurological findings in human immunodeficiency virus positive patients. J Laryngol Otol 2008;122:1289–94CrossRefGoogle ScholarPubMed
19Kevetter, GA, Correia, MJ. Vestibular system. In: Roland, PS, Marple, BF, Meyerhoff, WL, eds. Hearing Loss. New York: Thieme, 1997;54–70Google Scholar
20Bennet, M. The vertigo case history. In: Jacobson, GP, Shepard, NT, eds. Balance Function Assessment and Management. San Diego, Oxford, Brisbane: Plural Publishing, 2008;45–62Google Scholar
21Khoza, K, Ross, E. Auditory function in a group of adults infected with HIV/AIDS in Gauteng, South Africa. S Afr J Commun Disord 2002;49:17–27Google Scholar
22Marra, CM, Wechkin, HA, Longstreth, WT, Rees, TS, Syapin, CL, Gates, GA. Antiretroviral therapy in patients infected with HIV-1. Arch Neurol 1997;5:407–10CrossRefGoogle Scholar
23Hofmeyr, L, Baker, M. Balance disorders associated with HIV/AIDS. In: Swanepoel, DW, Louw, B, eds. HIV/AIDS Related Communication, Hearing and Swallowing Disorders. San Diego, Oxford, Brisbane: Plural Publishing, 2010;289–349Google Scholar
24Zapor, MJ, Cozza, KL, Wynn, GH, Wortmann, GW, Scott, CA. Antiretrovirals, part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors). Psychosomatics 2004;45:524–35CrossRefGoogle ScholarPubMed
25Mira, E. Improving the quality of life in patients with vestibular disorders: consequences of vestibular disorders. Int J Clin Pract 2008;62:109–14CrossRefGoogle ScholarPubMed
26Fielder, H, Denholm, SW, Lyons, RA, Fielder, CP. Measurements of health status in patients with vertigo. Clin Otolaryngol 1996;21:124–6CrossRefGoogle ScholarPubMed
27Da Silva, JG, Hyppolito, MA, De Oliveira, JA, Corrado, AP, Ito, IY, Carvalho, I. Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. Bioorg Med Chem 2007;15:3624–34CrossRefGoogle ScholarPubMed
28Selimoglu, E. Aminoglycoside-induced ototoxicity. Curr Pharm Des 2007;13:119–26CrossRefGoogle ScholarPubMed
29Palacios, GC, Montalvo, MS, Fraire, MI, Leon, E, Alvarez, MT, Solorzano, F. Audiologic and vestibular findings in a sample of human immunodeficiency virus type-1-infected Mexican children under highly active antiretroviral therapy. Int J Pediatr Otorhinolaryngol 2008;72:1671–81CrossRefGoogle Scholar
30Macher, AM. Otosyphilis: auditory and vestibular presentations. American Jails 2008;22:61–5Google Scholar
31Teggi, R, Giordano, L, Pistorio, V, Bussi, M. Vestibular function in HIV patients: preliminary report. Acta Otorhinolaryngol Ital 2006;26:140–6Google ScholarPubMed
32Dellepiane, M, Medicina, MC, Mora, R, Salami, A. Static and dynamic posturography in patients with asymptomatic HIV-1 infection and AIDS. Acta Otorhinolaryngol Ital 2005;25:353–8Google ScholarPubMed
33Song, JJ, Lee, HM, Chae, SW, Hwang, SJ. Bilateral otosyphilis in a patient with HIV infection. Eur Arch Otorhinolaryngol 2005;262:972–4CrossRefGoogle Scholar
34Castello, E, Baroni, N, Pallestrini, E. Neurotological and auditory brain stem response findings in human immunodeficiency virus-positive patients without neurologic manifestations. Ann Otol Rhinol Laryngol 1998;107:1054–60CrossRefGoogle ScholarPubMed
35Johnston, JL, Miller, JD, Nath, A. Ocular motor dysfunction in HIV-1-infected subjects: a quantitative oculographic analysis. Neurology 1996;46:451–7CrossRefGoogle ScholarPubMed
36Pappas, DG Jr, Roland, JT Jr, Lim, J, Lai, A, Hillman, DE. Ultrastructural findings in the vestibular end-organs of AIDS cases. Am J Otol 1995;16:140–5Google ScholarPubMed
37Grimaldi, LME, Luzi, L, Martino, GV, Furlan, R, Nemni, R, Antonelli, A et al. Bilateral eighth cranial nerve neuropathy in human immunodeficiency virus infection. J Neurol 1993;240:363–6CrossRefGoogle ScholarPubMed
38Chandrasekhar, SS, Siverls, V, Chandra Sekhar, HK. Histopathologic and ultrastructural changes in the temporal bones of HIV-infected human adults. Am J Otol 1992;13:207–14Google ScholarPubMed
39Hausler, R, Vibert, D, Koralnik, IJ, Hirschel, B. Neuro-otological manifestations in different stages of HIV infection. Acta Otolaryngol Suppl 1991;481:515–21CrossRefGoogle ScholarPubMed
40Hart, CW, Cokely, CG, Schupbach, J, Dal Canto, MC, Coppleson, LW. Neurotologic findings of a patient with acquired immune deficiency syndrome. Ear Hear 1989;10:68–76CrossRefGoogle ScholarPubMed
41Kohan, D, Hammerschlag, PE, Holliday, RA. Otologic diseases in AIDS patients: CT correlation. Laryngoscope 1990;11:1326–30CrossRefGoogle Scholar
42Van der Stappen, A, Wuytts, FL, Van de Heyning, PH. Computerized electronystagmography: normative data revisited. Acta Otolaryngol 2000;120:724–30CrossRefGoogle Scholar
43Halmagyi, GM, Cremer, PD, Anderson, J, Murofushi, T, Curthoys, S. Isolated directional preponderance of caloric nystagmus: I. Clinical significance. Am J Otol 2000;21:559–67Google ScholarPubMed