Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-25T19:13:14.459Z Has data issue: false hasContentIssue false
  • English
  • Français

Surgery alone versus post-operative radiotherapy for sinonasal malignant melanoma: a meta-analysis

Published online by Cambridge University Press:  24 January 2019

R Hu  and
B-B Yang
R Hu
Affiliation:
Department of Otolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China
B-B Yang*
Affiliation:
Department of Otolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China
*
Author for correspondence: Dr Bei-Bei Yang, Department of Otolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Jiefang Road 88, Hangzhou 310000, Zhejiang, China E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Sinonasal malignant melanoma is a relatively rare malignancy with poor prognosis, and effective treatments remain elusive. This analysis aimed to explore whether post-operative radiotherapy conferred any survival advantages in patients with this disease when compared with surgery alone.

Methods

Published studies were identified by searching four electronic databases. The endpoints evaluated were: rates of overall survival, disease-free survival and local control.

Results

Twenty-eight studies including 1392 patients were identified. The results indicated that post-operative radiotherapy led to a significantly better three-year overall survival rate (p = 0.02), and suggested a borderline significant benefit for five-year overall survival (p = 0.05), when compared with surgery alone. However, no statistical advantage was found for disease-free survival, local control or one-year overall survival.

Conclusion

This meta-analysis indicated that adjuvant radiotherapy prolonged survival, but showed no benefit for disease-free survival or local control.

Keywords

MelanomaNasal CavityParanasal SinusesSurgical OncologyAdjuvant Radiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 12 , December 2018 , pp. 1051 - 1060
Copyright
Copyright © JLO (1984) Limited, 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr B-B Yang takes responsibility for the integrity of the content of the paper

References

1Gras-Cabrerizo, JR, León-Vintró, X, Tarruella, MM, Sarria, GP, Gonzalez, CB, Montserrat-Gili, JR et al. Management of sinonasal mucosal melanomas and comparison of classification staging systems. Am J Rhinol Allergy 2015;29:37–40Google Scholar
2Ahmed, OA, Kelly, C. Head and neck melanoma (excluding ocular melanoma): United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 2016;130:133–41Google Scholar
3Lund, VJ, Howard, DJ, Harding, L, Wei, WI. Management options and survival in malignant melanoma of the sinonasal mucosa. Laryngoscope 1999;109:208–11Google Scholar
4Lund, VJ, Chisholm, EJ, Howard, DJ, Wei, WI. Sinonasal malignant melanoma: an analysis of 115 cases assessing outcomes of surgery, postoperative radiotherapy and endoscopic resection. Rhinology 2012;50:203–10Google Scholar
5Kingdom, TT, Kaplan, MJ. Mucosal melanoma of the nasal cavity and paranasal sinuses. Head Neck 1995;17:184–9Google Scholar
6Bentzen, SM, Overgaard, J, Thames, HD, Overgaard, M, Vejby Hansen, P, von der Maase, H et al. Clinical radiobiology of malignant melanoma. Radiother Oncol 1989;16:169–82Google Scholar
7Gilain, L, Houette, A, Montalban, A, Mom, T, Saroul, N. Mucosal melanoma of the nasal cavity and paranasal sinuses. Eur Ann Otorhinolaryngol Head Neck Dis 2014;131:365–9Google Scholar
8Ganly, I, Patel, SG, Singh, B, Kraus, DH, Bridger, PG, Cantu, G et al. Craniofacial resection for malignant melanoma of the skull base: report of an international collaborative study. Arch Otolaryngol Head Neck Surg 2006;132:73–8Google Scholar
9Ellingwood, KE, Million, RR. Cancer of the nasal cavity and ethmoid/sphenoid sinuses. Cancer 1979;43:1517–26Google Scholar
10Katz, TS, Mendenhall, WM, Morris, CG, Amdur, RJ, Hinerman, RW, Villaret, DB. Malignant tumors of the nasal cavity and paranasal sinuses. Head Neck 2002;24:821–9Google Scholar
11Shukovsky, LJ, Fletcher, GH. Retinal and optic nerve complications in a high dose irradiation technique of ethmoid sinus and nasal cavity. Radiology 1972;104:629–34Google Scholar
12Waldron, JN, O'Sullivan, B, Warde, P, Gullane, P, Lui, FF, Payne, D et al. Ethmoid sinus cancer: twenty-nine cases managed with primary radiation therapy. Int J Radiat Oncol Biol Phys 1998;41:361–9Google Scholar
13Combs, SE, Konkel, S, Thilmann, C, Debus, J, Schulz-Ertner, D. Local high-dose radiotherapy and sparing of normal tissue using intensity-modulated radiotherapy (IMRT) for mucosal melanoma of the nasal cavity and paranasal sinuses. Strahlenther Onkol 2007;183:63–8Google Scholar
14Liétin, B, Montalban, A, Louvrier, C, Kemeny, JL, Mom, T, Gilain, L. Sinonasal mucosal melanomas. Eur Ann Otorhinolaryngol Head Neck Dis 2010;127:70–6Google Scholar
15Krengli, M, Masini, L, Kaanders, JH, Maingon, P, Oei, SB, Zouhair, A et al. Radiotherapy in the treatment of mucosal melanoma of the upper aerodigestive tract: analysis of 74 cases. A Rare Cancer Network study. Int J Radiat Oncol Biol Phys 2006;65:751–9Google Scholar
16Temam, S, Mamelle, G, Marandas, P, Wibault, P, Avril, MF, Janot, F et al. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer 2005;103:313–19Google Scholar
17Meleti, M, Leemans, CR, de Bree, R, Vescovi, P, Sesenna, E, van der Waal, I. Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy. Head Neck 2008;30:1543–51Google Scholar
18Patel, SG, Prasad, ML, Escrig, M, Singh, B, Shaha, AR, Kraus, DH et al. Primary mucosal malignant melanoma of the head and neck. Head Neck 2002;24:247–57Google Scholar
19Nandapalan, V, Roland, NJ, Helliwell, TR, Williams, EM, Hamilton, JW, Jones, AS. Mucosal melanoma of the head and neck. Clin Otolaryngol Allied Sci 1998;23:107–16Google Scholar
20Wu, AJ, Gomez, J, Zhung, JE, Chan, K, Gomez, DR, Wolden, SL et al. Radiotherapy after surgical resection for head and neck mucosal melanoma. Am J Clin Oncol 2010;33:281–5Google Scholar
21The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. In: http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm [1 May 2016]Google Scholar
22Higgins, JP, Thompson, SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002;21:1539–58Google Scholar
23Brandwein, MS, Rothstein, A, Lawson, W, Bodian, C, Urken, ML. Sinonasal melanoma. A clinicopathologic study of 25 cases and literature meta-analysis. Arch Otolaryngol Head Neck Surg 1997;123:290–6Google Scholar
24Cheng, YF, Lai, CC, Ho, CY, Shu, CH, Lin, CZ. Toward a better understanding of sinonasal mucosal melanoma: clinical review of 23 cases. J Chin Med Assoc 2007;70:24–9Google Scholar
25Clifton, N, Harrison, L, Bradley, PJ, Jones, NS. Malignant melanoma of nasal cavity and paranasal sinuses: report of 24 patients and literature review. J Laryngol Otol 2011;125:479–85Google Scholar
26Crawford, RI, Tron, VA, Ma, R, Rivers, JK. Sinonasal malignant melanoma – a clinicopathologic analysis of 18 cases. Melanoma Res 1995;5:261–6Google Scholar
27Dauer, EH, Lewis, JE, Rohlinger, AL, Weaver, AL, Olsen, KD. Sinonasal melanoma: a clinicopathologic review of 61 cases. Otolaryngol Head Neck Surg 2008;138:347–52Google Scholar
28Gal, TJ, Silver, N, Huang, B. Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope 2011;121:2026–33Google Scholar
29Hu, WH, Xie, FY, Wu, Y, Sun, Y, Ren, JQ, Chen, DZ. Clinical analysis of 24 patients with melanoma in the nasal cavity [in Chinese]. Chin J Radiat Oncol 2004;13:8–11Google Scholar
30Martin, JM, Porceddu, S, Weih, L, Corry, J, Peters, LJ. Outcomes in sinonasal mucosal melanoma. ANZ J Surg 2004;74:838–42Google Scholar
31Marunick, M, Oh, WS. Prosthodontic treatment considerations for patients with oral sinonasal mucosal malignant melanoma: a clinical report. J Prosthet Dent 2009;101:85–91Google Scholar
32Matias, C, Corde, J, Soares, J. Primary malignant melanoma of the nasal cavity: a clinicopathologic study of nine cases. J Surg Oncol 1998;39:29–32Google Scholar
33Meng, XJ, Ao, HF, Huang, WT, Chen, F, Sun, XC, Wang, JJ et al. Impact of different surgical and postoperative adjuvant treatment modalities on survival of sinonasal malignant melanoma. BMC Cancer 2014;14:608Google Scholar
34Panje, WR, Moran, WJ. Melanoma of the upper aerodigestive tract: a review of 21 cases. Head Neck Surg 1986;8:309–12Google Scholar
35Podboj, J, Smid, L. Endoscopic surgery with curative intent for malignant tumors of the nose and paranasal sinuses. Eur J Surg Oncol 2007;33:1081–6Google Scholar
36Roth, TN, Gengler, C, Huber, GF, Holzmann, D. Outcome of sinonasal melanoma: clinical experience and review of the literature. Head Neck 2010;32:1385–92Google Scholar
37Sun, CZ, Li, QL, Hu, ZD, Jiang, YE, Song, M, Yang, AK. Treatment and prognosis in sinonasal mucosal melanoma: a retrospective analysis of 65 patients from a single cancer center. Head Neck 2014;36:675–81Google Scholar
38Thariat, J, Poissonnet, G, Marcy, PY, Lattes, L, Butori, C, Guevara, N et al. Effect of surgical modality and hypofractionated split-course radiotherapy on local control and survival from sinonasal mucosal melanoma. Clin Oncol (R Coll Radiol) 2011;23:579–86Google Scholar
39Trapp, TK, Fu, YS, Calcaterra, TC. Melanoma of the nasal and paranasal sinus mucosa. Arch Otolaryngol Head Neck Surg 1987;113:1086–9Google Scholar
40Wei, R, Jiang, WH, Shen, LF. Clinical analysis of 19 patients with malignant melanoma of the nasal cavity [in Chinese]. Hunan Yi Ke Da Xue Xue Bao 2003;28:121–2Google Scholar
41Won, TB, Choi, KY, Rhee, CS, Jin, HR, Yi, JS, Dhong, HJ et al. Treatment outcomes of sinonasal malignant melanoma: a Korean multicenter study. Int Forum Allergy Rhinol 2015;5:950–9Google Scholar
42Breik, O, Sim, F, Wong, T, Nastri, A, Iseli, TA, Wiesenfeld, D. Survival outcomes of mucosal melanoma in the head and neck: case series and review of current treatment guidelines. J Oral Maxillofac Surg 2016;74:1859–71Google Scholar
43Letievant, JC, Poupart, M, Ambrun, A, Colin, C, Pignat, JC. Single-center retrospective series of fourteen patients with mucosal melanoma of the nasal cavity and paranasal sinuses. Eur Ann Otorhinolaryngol Head Neck Dis 2016;133:387–91Google Scholar
44Samstein, RM, Carvajal, RD, Postow, MA, Callahan, MK, Shoushtari, AN, Patel, SG et al. Localized sinonasal mucosal melanoma: outcomes and associations with stage, radiotherapy, and positron emission tomography response. Head Neck 2016;38:1310–17Google Scholar
45Dréno, M, Georges, M, Espitalier, F, Ferron, C, Charnolé, A, Dréno, B et al. Sinonasal mucosal melanoma: a 44-case study and literature analysis. Eur Ann Otorhinolaryngol Head Neck Dis 2017;17:30041–8Google Scholar
46Amit, M, Tam, S, Abdelmeguid, AS, Kupferman, ME, Su, SY, Raza, SM et al. Role of adjuvant treatment in sinonasal mucosal melanoma. J Neurol Surg B Skull Base 2017;78:512–18Google Scholar
47Temam, S, Mamelle, G, Marandas, P, Wibault, P, Avril, MF, Janot, F et al. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer 2005;103:313–19Google Scholar
48López, F, Rodrigo, JP, Cardesa, A, Triantafyllou, A, Devaney, KO, Mendenhall, WM et al. Update on primary head and neck mucosal melanoma. Head Neck 2016;38:147–55Google Scholar
49Moreno, MA, Roberts, DB, Kupferman, ME, DeMonte, F, El-Naggar, AK, Williams, M et al. Mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the M.D. Anderson Cancer Center. Cancer 2010;116:2215–23Google Scholar
50Krengli, M, Jereczek-Fossa, BA, Kaanders, JH, Masini, L, Beldì, D, Orecchia, R. What is the role of radiotherapy in the treatment of mucosal melanoma of the head and neck? Crit Rev Oncol Hematol 2008;65:121–8Google Scholar
51Miglani, A, Patel, SH, Kosiorek, HE, Hinni, ML, Hayden, RE, Lal, D. Endoscopic resection of sinonasal mucosal melanoma has comparable outcomes to open approaches. Am J Rhinol Allergy 2017;31:200–4Google Scholar
52Gore, MR, Zanation, AM. Survival in sinonasal melanoma: a meta-analysis. J Neurol Surg B Skull Base 2012;73:157–62Google Scholar