Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-08T21:32:35.509Z Has data issue: false hasContentIssue false
  • English
  • Français

Studying the result of underlay myringoplasty using platelet-rich plasma

Published online by Cambridge University Press:  29 October 2018

S P S Yadav ,
J S Malik ,
P Malik ,
P K Sehgal ,
J S Gulia  and
R K Ranga
S P S Yadav
Affiliation:
Department of Otolaryngology, Post-Graduate Institute of Medical Sciences (‘PGIMS’), Rohtak, India
J S Malik
Affiliation:
Department of Otolaryngology, Post-Graduate Institute of Medical Sciences (‘PGIMS’), Rohtak, India
P Malik*
Affiliation:
Department of Otolaryngology, Post-Graduate Institute of Medical Sciences (‘PGIMS’), Rohtak, India
P K Sehgal
Affiliation:
Department of Blood Transfusion, Post-Graduate Institute of Medical Sciences (‘PGIMS’), Rohtak, India
J S Gulia
Affiliation:
Department of Otolaryngology, Post-Graduate Institute of Medical Sciences (‘PGIMS’), Rohtak, India
R K Ranga
Affiliation:
Department of Otolaryngology, Post-Graduate Institute of Medical Sciences (‘PGIMS’), Rohtak, India
*
Author for correspondence: Dr Priya Malik, Room no. 211, Girls Hostel, PGIMS, Rohtak 124001, Haryana, India E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Perforations of the tympanic membrane are treated with various surgical techniques and materials. This study aimed to determine the efficacy of platelet-rich plasma during underlay myringoplasty.

Methods

The study included 40 patients. Autologous platelet-rich plasma was applied in-between temporalis fascia graft and tympanic membrane remnant during underlay myringoplasty in group 1 (n = 20). The outcome was evaluated after three months and compared with group 2 (n = 20), a control group that underwent routine underlay tympanoplasty.

Results

After three months’ follow up, graft uptake was 95 per cent in group 1 and 85 per cent in group 2 (p < 0.03). Mean hearing threshold gain was 18.62 dB in group 1 and 13.15 dB in group 2. This difference was statistically significant (p < 0.01).

Conclusion

Platelet-rich plasma, with its ease of preparation technique, availability, low cost, autologous nature and good graft uptake rate, justifies its use in tympanoplasty type I procedures.

Keywords

Platelet-Rich PlasmaTympanoplastyOtitis Media, SuppurativeMyringoplastyPlatelet-Derived Growth Factor
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 11 , November 2018 , pp. 990 - 994
Copyright
Copyright © JLO (1984) Limited, 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr P Malik takes responsibility for the integrity of the content of the paper

References

1Lee, YP, Auo, HJ, Kang, JM. Loop overlay tympanoplasty for anterior or subtotal perforations. Auris Nasus Larynx 2010;37:162–6Google Scholar
2Gopen, Q. Pathology and clinical course of inflammatory disease of the middle ear. In: Gulya, AJ, Minor, LB, Poe, DS, eds. Glasscock–Shambaugh Surgery of the Ear, 6th edn. Shelton, CT: Peoples Medical Publishing House-USA. 2010;425–36Google Scholar
3Maroto, PD, Gutiérrez, JJ, Jiménez, MC, Morente, JC, Rodríguez, VP, Benítez, PN. Functional results in myringoplasties [in Spanish]. Acta Otorrinolaringol Esp 2010;61:94–9Google Scholar
4Jung, TT, Park, SK. Mediolateral graft tympanoplasty for anterior or subtotal tympanic membrane perforation. Otolaryngol Head Neck Surg 2005;132:532–6Google Scholar
5Yoo, J. Clinical application of tissue adhesives in soft-tissue surgery of the head and neck. Curr Opin Otolaryngol Head Neck Surg 2008;16:312–17Google Scholar
6Carter, MJ, Fylling, CP, Parnell, LK. Use of platelet rich plasma gel on wound healing: a systematic review and meta-analysis. Eplasty 2011;11:e38Google Scholar
7Mehta, S, Watson, JT. Platelet rich concentrate: basic science and current clinical applications. J Orthop Trauma 2008;22:432–8Google Scholar
8Marx, RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent 2001;10:225–8Google Scholar
9Gasling, VL, Acil, Y, Springer, IN, Hubert, N, Wiltfag, J. Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:48–55Google Scholar
10Nikolidakis, D, Jansen, JA. The biology of platelet-rich plasma and its application in oral surgery: literature review. Tissue Eng Part B Rev 2008;14:249–58Google Scholar
11Everts, PA, Brown Mahoney, C, Hoffmann, JJ, Schönberger, JP, Box, HA, van Zundert, A et al. Platelet-rich plasma preparation using three devices: implications for platelet activation and platelet growth factor release. Growth Factors 2006;24:165–71Google Scholar
12Gulia, JS, Yadav, SP, Khaowas, A. Medio-lateral myringoplasty versus medial myringoplasty: a comparative study. Otolaryngol Head Neck Surg 2013;149(2 suppl):P231Google Scholar
13Fiorino, F, Barbieri, F. ‘Over-under’ myringoplasty with umbus-anchored graft. J Laryngol Otol 2008;122:854–7Google Scholar
14Sakagami, M, Yuasa, R, Yuasa, Y. Simple underlay myringoplasty. J Laryngol Otol 2007;121:840–4Google Scholar
15Driver, VR, Hanft, J, Fylling, CP, Beriou, JM; Autologel Diabetic Foot Ulcer Study Group. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage 2006;52:68–70,72,74Google Scholar
16Soumekh, B, Hom, DB, Levine, S, Juhn, SK, Antonelli, PJ. Treatment of chronic tympanic-membrane perforations with a platelet-derived releasate. Am J Otol 1996;17:506–11Google Scholar
17Yeo, SW, Kim, SW, Suh, BD, Cho, SH. Effects of platelet-derived growth factor-AA on the healing process of tympanic membrane perforation. Am J Otolaryngol 2000;21:153–60Google Scholar
18Erkilet, E, Koyuncu, M, Atmaca, S, Yarim, M. Platelet-rich plasma improves healing of tympanic membrane perforations: experimental study. J Laryngol Otol 2009;123:482–7Google Scholar
19Farrag, TY, Lehar, M, Verhaegen, P, Carson, KA, Byrne, PJ. Effect of platelet rich plasma and fibrin sealant on facial nerve regeneration in a rat model. Laryngoscope 2007;117:157–65Google Scholar
20Platelet Rich Fibrin for the Repair of Tympanic Membrane. In: https://www.researchposters.com/Posters/AAOHNSF/aao2012/SP398.pdf [27 September 2018]Google Scholar
21Navarrete Alvaro, ML, Ortiz, N, Rodriguez, L, Boemo, R, Fuentes, JF, Mateo, A et al. Pilot study on the efficiency of the biostimulation with autologous plasma rich in platelet growth factors in otorhinolaryngology: otologic surgery (tympanoplasty type I). ISRN Surg 2011;2011:451020Google Scholar
22Gopalakrishnan, S, Venkatasamy, P, Vivekanandamurthy, K. A study on efficacy of autologous platelet rich plasma in myringoplasty. Online J Otolaryngol 2013;3:36–51Google Scholar
23Gonshor, A. Technique for producing platelet-rich plasma and platelet concentrate: background and process. Int J Periodontics Restorative Dent 2002;22:547–57Google Scholar