Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-05T10:40:01.244Z Has data issue: false hasContentIssue false
  • English
  • Français

Skeletal lesions in von Recklinghausen's disease of the head and neck in Nigerian Africans

Published online by Cambridge University Press:  29 June 2007

G. T. A. Ijaduola ,
S. A. Ademiluyi  and
D. A. Olarenwaju
G. T. A. Ijaduola*
Affiliation:
Lagos, Nigeria
S. A. Ademiluyi
Affiliation:
Lagos, Nigeria
D. A. Olarenwaju
Affiliation:
Lagos, Nigeria
*
G. T. A. Ijaduola, F.R.C.S., (Eng. & Glasg.), Consultant ENT Surgeon, PO Box 5671, surulere-Lagos, Nigeria.
Get access Rights & Permissions [Opens in a new window]

Summary

A study of skeletal lesions in the head and neck region of 20 adult patients with von Recklinghausen's disease, seen in the Surgical Out Patient clinic of Lagos University Teaching Hospital from 1979 to 1985, has been carried out. Among the 20 patients, 13 (65 per cent) had symptoms related to the head and neck while 7 (37 per cent) did not; however, on radiological screening, all of them were observed to have skeletal lesions. The commonest feature was enlarged intervertebral nerve root exit foramina from mesodermal dysplasia, which occurred in 16 (80 per cent) of our patients. Other major findings were erosion of the mandible, 8 (40 per cent); erosion of the wings of the sphenoid, 4 (20 per cent); poor mastoid bone pneu-matisation, 3 (15 per cent); erosion of the parietal bone, 3 (15 per cent) and heterotopic bone formation, 1 (5 per cent). Congenital calvarial defects were not detected. In view of the fact that all our patients showed radiologically detectable skeletal lesions of the head and neck, despite absence of symptoms in 35 per cent, it is advisable that all patients with von Recklinghausen's disease should routinely have radiological screening of this region, to detect early lesions.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 7 , July 1986 , pp. 823 - 830
Copyright
Copyright © JLO (1984) Limited 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Borberg, A. (1951) Clinical and genetic investigations into tuberous sclerosis and Recklinghausen's neurofibromatosis. Acta psychiatica neurologica, Supplement, 71: 1–239.Google ScholarPubMed
Burrows, E. H. (1963) Bone changes in orbital neurofibromatosis. British Journal of Radiology, 36: 549–561.CrossRefGoogle ScholarPubMed
Davidson, K. C. (1966) Cranial and intracranial lesions in neurofibromatosis. Americal Journal of Roentgenology, 98: 550–556.CrossRefGoogle ScholarPubMed
Gupta, S. K., Nema, H. V., Bhattia, P. L., Sasibabu, K. and Kesgarwani, R. (1979) The radiological features of craniofacial neurofibromatosis. Clinical Radiology, 3: 553–557.CrossRefGoogle Scholar
Handa, J., Kayama, J., Shimiza, Y. and Yomeida, S. (1975) Skull defects involving the Lambdoid suture. Surgical Neurology, 3: 119–121.Google ScholarPubMed
Holt, J. G. (1978) Neurofibromatosis in children. A. J. R., 130: 615–635.Google ScholarPubMed
Holt, J. C. and Pugh, D. G. (1961) Skeletal lesions in neurofibromatosis. Radiology, 76: 1–20.Google Scholar
Ijaduola, G. T. A. and Ademiluyi, S. A. (1986) Otorhinolaryngological features of von Recklinghausen's disease in Nigerian Africans. Journal of Laryngology and Otology (in press).Google Scholar
James, P. L. and Treggiden, R. (1975) Multiple neurofibromatosis associated with facial asymmetry. Journal of Oral Surgery, 33: 439–442.Google ScholarPubMed
Lewald, L. J. (1933) Congenital absence of superior orbital wall associated with pulsating exophthalmos. American Journal of Roentgenology, 30: 755–764.Google Scholar
McCarroll, H. R. (1950) Clinical manifestations of congenital neurofibromatosis. Journal of Bone and Joint Surgery, 32A: 601–617.CrossRefGoogle Scholar
Mendel, G. A. (1978) The pedicle in neurofibromatosis. American Journal of Roentgenology, 130: 675–678.CrossRefGoogle Scholar
Preston, F. W. W. S., Walsh, T. H. and Clarke, J. (1952) Cutaneous neurofibromatosis (von Recklinghausen's disease). Archives of Surgery, 64: 813.Google ScholarPubMed
Riccardi, V. H. (1980) Pathophysiology of neurofibromatosis IV, dermatologic insight into heterogenicity and pathogenesis. Journal of the American Academy of Dermatology, 3: 157–166.CrossRefGoogle ScholarPubMed
Rodriguez, H. A. and Berthrong, M. (1966) Multiple intracranial tumours in von Recklinghausen's neurofibromatosis. Archives of Neurology, 84: 467–475.CrossRefGoogle Scholar
Rosman, N. P. and Pearce, J. (1967) The brain and multiple neurofibromatosis: a suggested neuropathological basis for the associated mental defect. Brain, 90: 829–837.CrossRefGoogle ScholarPubMed