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Salvage intratympanic steroid therapy for sudden sensorineural hearing loss: our real-life experience in 32 patients

Published online by Cambridge University Press:  12 January 2022

T Ringrose Open the ORCID record for T Ringrose [Opens in a new window] ,
T C Biggs ,
L Jones ,
A Yunus ,
A Onderková ,
A Amir-Ghasemi ,
V Osei-Lah ,
J Hilton  and
J Buckland
T Ringrose*
Affiliation:
Department of Otolaryngology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK
T C Biggs
Affiliation:
Department of Otolaryngology, University Hospital Southampton NHS Foundation Trust, UK
L Jones
Affiliation:
Department of Otolaryngology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK
A Yunus
Affiliation:
Portsmouth Hospitals University NHS Trust, Southampton, UK
A Onderková
Affiliation:
Portsmouth Hospitals University NHS Trust, Southampton, UK
A Amir-Ghasemi
Affiliation:
Department of Surgery, Portsmouth Hospitals University NHS Trust, Portsmouth, UK
V Osei-Lah
Affiliation:
Audiovestibular Medicine, Portsmouth Hospitals University NHS Trust, Portsmouth, UK
J Hilton
Affiliation:
Department of Otolaryngology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK
J Buckland
Affiliation:
Department of Otolaryngology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK
*
Author for correspondence: Dr Thomas Ringrose, Department of Otolaryngology, Portsmouth Hospitals University NHS Trust, Cosham, PortsmouthPO6 3LY, UK E-mail: [email protected]
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Abstract

Objective

To examine the role of salvage intratympanic steroid injections in patients presenting with idiopathic sudden sensorineural hearing loss following a poor response to initial oral steroid treatment.

Methods

A retrospective analysis of patient records over the course of four years was conducted, and pure tone thresholds were reviewed before treatment, after oral steroid therapy and six weeks after intratympanic steroid injection therapy.

Results

After oral steroid therapy alone, there was a mean average threshold change of 6.2 dB HL (range, −13.8–33.8 dB). This change was statistically significant for severely affected patients (those with an average presenting threshold of over 71 dB). The mean average threshold improvement following intratympanic steroid injection therapy was 2.9 dB (range, −22.5–61.3 dB); this was not statistically significant.

Conclusion

Some patients experienced moderate improvement following intratympanic steroid injection therapy; however, no specific subgroup was identified to benefit more from intratympanic steroid injection therapy.

Keywords

Sensorineural, Hearing LossIntratympanic InjectionSteroidAudiogramManagement
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 9 , September 2022 , pp. 827 - 830
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr T Ringrose takes responsibility for the integrity of the content of the paper

References

Schreiber, BE, Agrup, C, Haskard, DO, Luxon, LM. Sudden sensorineural hearing loss. Lancet 2010;375:1203–11CrossRefGoogle ScholarPubMed
Stachler, R, Chandrasekhar, S, Archer, S, Rosenfeld, RM, Schwartz, SR, Barrs, DM; American Academy of Otolaryngology – Head and Neck Surgery et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg 2012;146(suppl 3):S1–35CrossRefGoogle ScholarPubMed
Chandrasekhar, S, Tsai Do, B, Schwartz, S, Bontempo, L, Faucett, E, Finestone, S et al. Clinical practice guideline: sudden hearing loss (update). Otolaryngol Head Neck Surg 2019;161(suppl 1):S1–45CrossRefGoogle Scholar
ENT-UK. Management of suspected unilateral idiopathic sudden sensorineural hearing loss in adults. In: https://www.entuk.org/resources/98/management_of_suspected_unilateral_idiopathic_sudden_sensorineural_hearing_loss_in_adults [24 March 2022]Google Scholar
Spear, S, Schwartz, S. Intratympanic steroids for sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 2011;145:534–43CrossRefGoogle ScholarPubMed
Gurgel, R, Jacklet, R, Dobie, R, Popelka, G. A new standardized format for reporting hearing outcome in clinical trials. Otolaryngol Head Neck Surg 2013;149:349–50Google Scholar
Xenellis, J, Papadimitriou, N, Nikolopoulos, T, Maragoudakis, P, Segas, J, Tzagaroulakis, A et al. Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study. Otolaryngol Head Neck Surg 2006;134:940–5CrossRefGoogle ScholarPubMed