Hostname: page-component-669899f699-7xsfk Total loading time: 0 Render date: 2025-04-27T10:55:59.676Z Has data issue: false hasContentIssue false
  • English
  • Français

Research status of otitis media with effusion after radiotherapy

Published online by Cambridge University Press:  06 December 2024

Jingqian Tan Open the ORCID record for Jingqian Tan [Opens in a new window] ,
Jianyan Wang ,
Liling Li ,
Jia Luo ,
Dan Chen ,
Xuexin Lin  and
Peng Li
Jingqian Tan
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
Jianyan Wang
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
Liling Li
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
Jia Luo
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
Dan Chen
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
Xuexin Lin
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Zhuhai People’s Hospital, Zhuhai, Guangdong, China
Peng Li*
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
*
Corresponding author: Peng Li; Email: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

This brief review summarises the efficacy of the treatments for post-irradiation otitis media with effusion.

Method

Literature review.

Results

Studies suggest that tympanocentesis is recommended for patients with post-irradiation otitis media with effusion The efficacy of balloon dilatation Eustachian tube for post-irradiation otitis media with effusion remains unclear.

Conclusion

The efficacy of different treatments for post-irradiation otitis media with effusion is unclear. Therefore, there are no recognised clinical guidelines, and long-term clinical research with a large sample size is needed.

Keywords

Nasopharyngeal carcinomaRadiation therapyOtitis media with effusionEustachian tubeBalloon dilation of eustachian tube
Type
Review Article
Information
The Journal of Laryngology & Otology , First View , pp. 1 - 5
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Peng Li takes responsibility for the integrity of the content of the paper

References

Chen, YP, Chan, ATC, Le, QT, Blanchard, P, Sun, Y, Ma, J. Nasopharyngeal carcinoma. Lancet 2019;394:64–80Google Scholar
Xie, H, Sun, WZ. Formation mechanism of secretory otitis media and its correlation with nasopharyngeal carcinoma and radiotherapy, and the treatment progress. Med Recapitulate 2013;19:Google Scholar
Su, CY, Hsu, SP, Lui, CC. Computed tomography, magnetic resonance imaging, and electromyographic studies of tensor veli palatini muscles in patients with nasopharyngeal carcinoma. Laryngoscope 1993;103:Google Scholar
Hsu, MM, Young, YH, Lin, KL. Eustachian tube function of patients with nasopharyngeal carcinoma. Ann Otol Rhinol Laryngol 1995;104:Google Scholar
Berg, NO, Lindgren, M. Dose factors and morphology of delayed radiation lesions of the internal and middle ear in rabbits. Acta Radiol (Stockh) 1961;56:Google Scholar
Borsanyi, SJ. The effects of radiation therapy on the ear: with particular reference to radiation otitis media. South Med J 1962;55:Google Scholar
Tang, HZ. Diagnostic significance of CT scan in nasopharyngeal carcinoma complicated with secretory otitis media. J Imag Res Med App 2021;5:89–90Google Scholar
Zhao, RS, Qing, HM, Zhong, SX. Efficacy of myringotomy with ventilation tube insertion and tympanocentesis for otitis media with effusion after radiotherapy for nasopharyngeal carcinoma: a meta-analysis study. Chinese J Otol 2020;18:Google Scholar
Xu, YD, Ou, YK, Zheng, YQ, Chen, Y, Ji, SF. The treatment for postirradiation otitis media with effusion: a study of three methods. Laryngoscope 2008;118:Google Scholar
Sun, JG, Wang, HX, Xiao, FG. Clinical observation of “triple therapy” in treatment of secretory otitis media after radiotherapy for nasopharyngeal carcinoma. J Aud Speech Pathol 2013;21:Google Scholar
Ai, YQ, Zhao, Q, Chen, JX. The role of early intervention in mitigating secretory otitis media following radiotherapy in nasopharyngeal carcinoma. Chinese J Otol 2014;12:Google Scholar
Young, YH, Lin, KL, Ko, JY. Otitis media with effusion in patients with nasopharyngeal carcinoma, postirradiation. Arch Otolaryngol Head Neck Surg 1995;121:Google Scholar
Gong, TG, Wen, Z, Ke, CY. Aetiology and pathogenesis of post-radiation otitis media with effusion in patients with nasopharyngeal carcinoma. Chinese J Otol 2018;16:Google Scholar
Xian, XQ, Jiang, G, Xie, MQ. Clinical application of tympanostomy tube placement to prevent secretory otitis media in patients with nasopharyngeal carcinoma after radiotherapy. J Clin Otorhinolaryngol Head Neck Surg 2013;27:Google Scholar
Bayramoğlu, I, Ardiç, FN, Kara, CO, Ozüer, MZ, Katircioğlu, O, Topuz, B. Importance of mastoid pneumatization on secretory otitis media. Int J Pediatr Otorhinolaryngol 1997;40:Google Scholar
Ockermann, T, Reineke, U, Upile, T, Ebmeyer, J, Sudhoff, H. Balloon dilatation Eustachian tuboplasty: a clinical study. Laryngoscope 2010;120:Google Scholar
Silvola, J, Kivekäs, I, Poe, DS. Balloon dilation of the cartilaginous portion of the Eustachian tube. Otolaryngol Head Neck Surg 2014;151:Google Scholar
Randrup, TS, Ovesen, T. Balloon Eustachian tuboplasty: a systematic review. Otolaryngol Head Neck Surg 2015;152:Google Scholar
Pan, HS, Wang, ZH. Effect of endoscopic balloon dilatation of Eustachian tube on Eustachian tube function in patients with secretory otitis media after radiotherapy for nasopharyngeal carcinoma. Lab Med Clinic 2022;19:Google Scholar
Zhu, SR, Sun, J. Effects of balloon Eustachian tuboplasty combined with Eustachian tube dilatation in treatment of patients with secretory otitis media after radiotherapy for nasopharyngeal carcinoma. Med J Chinese People’s Health 2023;35(11):Google Scholar
Sun, H, Cao, C, Qiu, X, Hu, J, Zhang, J. Efficacy of balloon dilatation of the Eustachian tube in patients with refractory otitis media with effusion after radiotherapy for nasopharyngeal carcinoma. Am J Otolaryngol 2020;41:Google Scholar
Wong, MSL, Prepageran, N. Preliminary results of a pilot study on the safety and efficacy of balloon dilatation of the Eustachian tube for nasopharyngeal cancer patients with chronic Eustachian tube dysfunction post irradiation. J Laryngol Otol 2021;135:Google Scholar
Plaza, G, Navarro, JJ, Alfaro, J, Sandoval, M, Marco, J. Consensus on treatment of obstructive Eustachian tube dysfunction with balloon Eustachian tuboplasty. Acta Otorrinolaringol Esp (Engl Ed) 2020;71:Google Scholar
Cutler, JL, Meyer, TA, Nguyen, SA, O’Malley, EM, Thackeray, L, Slater, PW. Long-term outcomes of balloon dilation for persistent Eustachian tube dysfunction. Otol Neurotol 2019;40:Google Scholar
Luukkainen, V, Kivekäs, I, Silvola, J, Jero, J, Sinkkonen, ST. Balloon Eustachian tuboplasty: systematic review of long-term outcomes and proposed indications. J Int Adv Otol 2018;14:Google Scholar
Chen, CY, Young, YH, Hsu, WC, Hsu, MM. Failure of grommet insertion in post-irradiation otitis media with effusion. Ann Otol Rhinol Laryngol 2001;110:Google Scholar
Charusripan, P, Khattiyawittayakun, L. The effectiveness of myringotomy and ventilation tube insertion versus observation in post-radiation otitis media with effusion. Eur Arch Otorhinolaryngol 2017;274:Google Scholar
Liang, KL, Su, MC, Twu, CW, Jiang, RS, Lin, JC, Shiao, JY. Long-term result of management of otitis media with effusion in patients with post-irradiated nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol 2011;268:Google Scholar
Miller, BJ, Elhassan, HA. Balloon dilatation of the Eustachian tube: an evidence‐based review of case series for those considering its use. Clinical Otolaryngology 2013;38:525–532Google Scholar
Swords, C. Balloon dilatation of the Eustachian tube for obstructive Eustachian tube dysfunction in adults. Cochrane Database of Systematic Reviews 2025;2Google Scholar
Ai, M, Liu, X, Lin, Y, Deng, H, Yu, F. Efficacy of balloon Eustachian tuboplasty plus tympanostomy tube insertion in postirradiation otitis media with effusion. Am J Otolaryngol 2024;45:Google Scholar