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Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma

Published online by Cambridge University Press:  11 September 2012

T Nakashima ,
R Yasumatsu ,
M Masuda ,
G L Clayman  and
S Komune
T Nakashima*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan
R Yasumatsu
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan
M Masuda
Affiliation:
Department of Otolaryngology, Kyushu Koseinenkin Hospital, Kitakyushu City, Japan
G L Clayman
Affiliation:
Department of Head and Neck Surgery, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
S Komune
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan
*
Address for correspondence: Dr Torahiko Nakashima, Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan Fax: +81 92 6425685 E-mail: [email protected]
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Abstract

Objective:

To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.

Design:

Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.

Results:

The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.

Conclusion:

Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.

Keywords

Oral CavitySquamous Cell CarcinomaCathepsinPathologyHeadpin Protein, Human
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 11 , November 2012 , pp. 1134 - 1137
Copyright
Copyright © JLO (1984) Limited 2012

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References

1 Lankelma, JM, Voorend, DM, Barwari, T, Koetsveld, J, Van der Spek, AH, De Porto, AP et al. Cathepsin L, target in cancer treatment? Life Sci 2010;86:225–33CrossRefGoogle ScholarPubMed
2 Macabeo-Ong, M, Shiboski, CH, Silverman, S, Ginzinger, DG, Dekker, N, Wong, DT et al. Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression. Oral Oncol 2003;39:638–47CrossRefGoogle ScholarPubMed
3 Xu, X, Yuan, G, Liu, W, Zhang, Y, Chen, W. Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance. Exp Oncol 2009;31:102–5Google ScholarPubMed
4 Spring, P, Nakashima, T, Frederick, M, Henderson, Y, Clayman, G. Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q. Biochem Biophys Res Commun 1999;264:299–304 CrossRefGoogle ScholarPubMed
5 Nakashima, T, Pak, SC, Silverman, GA, Spring, PM, Frederick, MJ, Clayman, GL. Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells. Biochim Biophys Acta 2000;1492:441–6CrossRefGoogle ScholarPubMed
6 Jayakumar, A, Kang, Y, Frederick, MJ, Pak, SC, Henderson, Y, Holton, PR et al. Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys 2003;409:367–74CrossRefGoogle ScholarPubMed
7 American Joint Committee on Cancer. AJCC Cancer Staging Manual, 6th edn. New York: Springer, 2002 Google Scholar
8 Kawasaki, G, Kato, Y, Mizuno, A. Cathepsin expression in oral squamous cell carcinoma: relationship with clinicopathologic factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:446–54CrossRefGoogle ScholarPubMed
9 Shellenberger, TD, Mazumdar, A, Henderson, Y, Briggs, K, Wang, M, Chattopadhyay, C et al. Headpin: a serpin with endogenous and exogenous suppression of angiogenesis. Cancer Res 2005;65:11501–9CrossRefGoogle ScholarPubMed