Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-02T22:41:50.877Z Has data issue: false hasContentIssue false
  • English
  • Français

Pro12Ala polymorphism in human peroxisome proliferator activated receptor gamma is associated with hyperlipidaemia in obstructive sleep apnoea hypopnoea syndrome

Published online by Cambridge University Press:  14 June 2011

J Guan ,
H Yi ,
X Wu ,
K Su ,
M Tao  and
S Yin
J Guan
Affiliation:
Department of Otolaryngology, The Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China
H Yi
Affiliation:
Department of Otolaryngology, The Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China
X Wu
Affiliation:
Department of Medical Genetics, Shanghai Jiao Tong University School of Medicine, Shanghai, China
K Su
Affiliation:
Department of Otolaryngology, The Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China
M Tao
Affiliation:
Ambulant Clinic, The Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China
S Yin*
Affiliation:
Department of Otolaryngology, The Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China
*
Address for correspondence: Dr Shankai Yin, The Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China Fax: +86 21 64834143 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Peroxisome proliferator activated receptor gamma is a ligand-dependent transcription factor with an important role in insulin resistance and obesity. We investigated the associations between the Pro12Ala polymorphism of this receptor, obstructive sleep apnoea hypopnoea syndrome and hyperlipidaemia risk factors, in a Chinese cohort.

Subjects and methods:

We recruited 420 obstructive sleep apnoea hypopnoea syndrome patients and 190 healthy controls. Genetic analysis was conducted by restriction fragment length polymorphism. The hyperlipidaemia risk in both the study and control groups was analysed.

Results:

Comparison of genotype and allele frequencies revealed no significant differences between patients and controls (p > 0.05). In patients, there was no correlation between genotype and clinical parameters (p > 0.05), apart from a significant association between the Ala12 allele and hyperlipidaemia (odds ratio = 2.181; p = 0.017; 95 per cent confidence interval = 1.133–4.198).

Conclusion:

In this Chinese cohort, the Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma was not associated with obstructive sleep apnoea hypopnoea syndrome, but was associated with increased hyperlipidaemia risk.

Keywords

HyperlipidemiasObstructive Sleep Apnea SyndromePPAR GammaPolymorphism
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 10 , October 2011 , pp. 1042 - 1048
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Young, T, Peppard, PE, Gottlieb, DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002;165:1217–39CrossRefGoogle ScholarPubMed
2West, SD, Nicoll, DJ, Stradling, JR. Prevalence of obstructive sleep apnea in men with type 2 diabetes. Thorax 2006;61:945–50CrossRefGoogle ScholarPubMed
3Vgontzas, AN, Bixler, EO, Chrousos, GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 2005;9:211–24CrossRefGoogle ScholarPubMed
4Hoffstein, V, Mateika, S. Differences in abdominal and neck circumferences in patients with and without sleep apnoea. Eur Respir J 1992;5:377–81CrossRefGoogle ScholarPubMed
5Suzuki, T, Nakano, H, Maekawa, J, Okamoto, Y, Ohnishi, Y, Yamauchi, M et al. Obstructive sleep apnea and carotid artery intima media thickness. Sleep 2004;27:129–33CrossRefGoogle ScholarPubMed
6Riha, RL, Brander, P, Vennelle, M, McArdle, N, Kerr, SM, Anderson, NH et al. Tumour necrosis factor-alpha (–308) gene polymorphism in obstructive sleep apnoea–hypopnoea syndrome. Eur Respir J 2005;26:673–8CrossRefGoogle ScholarPubMed
7Barcela, A, Elorza, MA, Barbe, F, Santos, C, Mayoralas, LR, Agusti, AG. Angiotensin converting enzyme in patients with sleep apnea syndrome: plasma activity and gene polymorphisms. Eur Respir J 2001;17:728–32CrossRefGoogle Scholar
8Hanaoka, M, Yu, X, Urushihata, K, Ota, M, Fujimoto, K, Kubo, K. Leptin and leptin receptor gene polymorphisms in obstructive sleep apnea syndrome. Chest 2008;133:79–85CrossRefGoogle ScholarPubMed
9Kaparianos, A, Sampsonas, F, Karkoulias, K, Spiropoulos, K. Obstructive sleep apnea syndrome and genes. Neth J Med 2006;64:280–9Google ScholarPubMed
10Ringel, J, Engeli, S, Distler, A, Sharma, AM. Pro12Ala missense mutation of the peroxisome proliferator activated receptor γ and diabetes mellitus. Biochem Biophys Res Commun 1999;254:450–3CrossRefGoogle ScholarPubMed
11Clement, K, Hercberg, S, Passinge, B, Galan, P, Varroud-Vial, M, Shuldiner, AR et al. The Pro115Gln and Pro12Ala PPARγ gene mutations in obesity and type 2 diabetes. Int J Obes Relat Metab Disord 2000;24:391–3CrossRefGoogle ScholarPubMed
12Cole, SA, Mitchell, BD, Hsueh, W-C, Pineda, P, Beamer, BA, Shuldiner, AR et al. The Pro12Ala variant of peroxisome proliferator-activated receptor-g 2 (PPAR-g 2) is associated with measures of obesity in Mexican Americans. Int J Obesity 2000;24:522–4CrossRefGoogle Scholar
13Masud, S, Ye, S. Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta analysis. J Med Genet 2003;40:773–80CrossRefGoogle ScholarPubMed
14Anonymous. The Report of an American Academy of Sleep Medicine Task Force. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999;22:667–89CrossRefGoogle Scholar
15Bonora, E, Targher, G, Alberiche, M, Bonadonna, RC, Saggiani, F, Zenere, MB et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000;23:57–63CrossRefGoogle ScholarPubMed
16Prasad, KN, Saxena, A, Ghoshal, UC, Bhagat, MR, Krishnani, N. Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease. Ann Oncol 2008;19:1299–303CrossRefGoogle ScholarPubMed
17Swarbrick, MM, Chapman, CM, McQuillan, BM, Hung, J, Thompson, PL, Beilby, JP. A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity. Eur J Endocrinol 2001;144:277–82CrossRefGoogle ScholarPubMed
18Lehrke, M, Lazar, MA. The many faces of PPAR gamma. Cell 2005;123:993–99CrossRefGoogle Scholar
19Evans, RM, Barish, GD, Wang, YX. PPARs and the complex journey to obesity. Nat Med 2004;10:355–61CrossRefGoogle ScholarPubMed
20Deeb, SS, Fajas, L, Nemoto, M, Pihlajamäki, J, Mykkänen, L, Kuusisto, J et al. A Pro12Ala substitution in PPAR gamma-2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nature Genet 1998;20:284–7CrossRefGoogle Scholar
21Gonzalez, SJL, Serrano, RM, Fernandez, PC, Laakso, M, Martínez Larrad, MT. Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population. Eur J Endocrinol 2002;147:495–501CrossRefGoogle Scholar
22Tonjes, A, Scholz, M, Loeffler, M, Stumvoll, M. Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care 2006;29:2489–97CrossRefGoogle ScholarPubMed
23Beamer, BA, Yen, CJ, Andersen, RE, Muller, D, Elahi, D, Cheskin, LJ et al. Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes 1998;47:1806–8CrossRefGoogle ScholarPubMed