Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-02T20:04:45.476Z Has data issue: false hasContentIssue false
  • English
  • Français

Potential effects of herbal medicines and nutritional supplements on coagulation in ENT practice

Published online by Cambridge University Press:  19 July 2007

F Javed ,
A Golagani  and
H Sharp
F Javed*
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, William Harvey Hospital, Ashford
A Golagani
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, William Harvey Hospital, Ashford
H Sharp
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Kent and Canterbury Hospital, Canterbury, Kent, UK
*
Address for correspondence: Mr Faisal Javed, 43 Kings Prospect, Ashford, Kent TN240 GX, UK. Fax: +44 1233 616770 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Herbal remedies and other natural supplements have become popular alternative medical therapy. Patients using these products may present to ENT surgeons with epistaxis or with unexpected, excessive peri-operative bleeding.

Objective:

The purpose of this review was to consolidate the available data regarding herb–drug interactions and the direct effects of herbal medicines and nutritional supplements in isolation, regarding disturbance in haemostasis, so as to emphasise their individual importance.

Method:

A literature review was performed using the Medline (PubMed) and UKMi databases.

Results:

Searches of these databases revealed 24 herbal products with documented interactions with anticoagulants and 98 herbal products with theoretical interactions with the coagulation system. Herbal products with effects on coagulation when given alone were also documented.

Conclusion:

When encountering patients presenting with epistaxis, or in the elective surgical setting, a thorough enquiry about the use of herbal medicines is of great importance.

Keywords

Herbal MedicinesHaemostasisEpistaxisCoagulation
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 2 , February 2008 , pp. 116 - 119
Copyright
Copyright © JLO (1984) Limited 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Everett, LL, Birmingham, PK, Williams, GD, Brenn, BR, Shapiro, JH. Herbal and homeopathic medication use in paediatric surgical patients. Ped Anesthesia 2005;15:455–60CrossRefGoogle Scholar
2 Brazier, NC, Levine, MHA. Drug-herb interaction among commonly used conventional medicines: a compendium for health care professionals. Am J Therapeutics 2003;10:163–9CrossRefGoogle ScholarPubMed
3 Ang-Lee, MK, Moss, J, Yuan, C. Herbal medicines and perioperative care. JAMA 2001;286:201–16CrossRefGoogle ScholarPubMed
4 UKMi. http://www.ukmi.nhs.uk/Secure/faqs/archieve/faq26.asp [July–August 2006]Google Scholar
5 Eisenberg, DM, Davis, RB, Ettner, SL, Appel, S, Wilkey, S, Rompay, MV et al. Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national survey. JAMA 1998;280:1569–75CrossRefGoogle ScholarPubMed
6 Seirpina, SV, Wollschlaeger, B, Blumenthal, M. Gingko biloba. Am Fam Physician 2003;68:923–6Google Scholar
7 Cesarani, A, Meloni, F, Alpini, D, Barozzi, S, Verderio, L, Boscani, PF. Ginkgo biloba (EGb 761) in the treatment of equilibrium disorders. Adv Ther 1998;15:291–304Google ScholarPubMed
8 Linde, K, Barrett, B, Wolkart, K, Bauer, R, Melchart, D. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev 2006;1:CD000530CrossRefGoogle Scholar
9 Amroyan, E, Gabrielian, E, Panossian, A, Wikman, G, Wagner, H. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27–31CrossRefGoogle ScholarPubMed
10 Josling, P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther 2001;18:189–93CrossRefGoogle ScholarPubMed
11 Bennett, J, Brown, CM. Use of herbal remedies by patients in a health maintenance organization. J Am Pharm Assoc (Wash) 2000;40:353–8CrossRefGoogle Scholar
12 Guo, R, Canter, PH, Ernst, E. Herbal medicines for the treatment of rhinosinusitis: a systematic review. Otolaryngol Head Neck Surg 2006;135:496–506CrossRefGoogle ScholarPubMed
13 Hodges, PJ, Kam, PCA. The perioperative implications of herbal medicines. Anesthesia 2002;57:889–99CrossRefGoogle ScholarPubMed
14 Kaye, AD, Clarke, RC, Sabar, R, Vig, S, Dhawan, KP, Hofbauer, R et al. Herbal medicines: current trends in anaesthesiology practice – a hospital survey. J Clin Anesth 2000;12:468–71CrossRefGoogle Scholar
15 Tsen, LC, Segal, S, Pothier, M, Bader, AM. Alternative medicine use in pre-surgical patients. Anesthesiology 2000;93:148–51CrossRefGoogle Scholar
16 Wang, S, Caldwell-Andrews, AA, Kain, ZN. The use of complementary and alternative medicines by surgical patients: a follow up survey study. Anesth Analg 2003;97:1010–15CrossRefGoogle ScholarPubMed
17 Jayasekera, N, Moghal, A, Kashif, F, Karalliedde, L. Herbal medicines and post operative haemorrhage. Anesthesia 2005;60:725–6CrossRefGoogle Scholar
18 Bent, S, Goldberg, H, Padula, A, Avins, AL. Spontaneous bleeding associated with gingko biloba; a case report and systematic review of the literature. J Gen Intern Med 2005;20:657–61CrossRefGoogle ScholarPubMed
19 Cheema, P, El-Mefty, O, Jazieh, AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167–9CrossRefGoogle Scholar
20 Weinrobe, MC, Montgomery, B. Acquired bleeding diathesis in a patient taking PC-SPES. N Engl J Med 2001;345:1213–14CrossRefGoogle Scholar
21 Burnham, BE. Garlic as a possible risk for postoperative bleeding. Plast Reconstr Surg 1995;95:213CrossRefGoogle ScholarPubMed
22 Ahmed, AA, Holub, BJ. Alteration and recovery of bleeding times, platelet aggregation and fatty acid composition of individual phospholipids in platelets of human subjects receiving a supplement of cod-liver oil. Lipids 1984;19:617–24CrossRefGoogle ScholarPubMed
23 Choudhury, N, Sharp, HR, Mir, N, Salama, NY. Epistaxis and oral anti-coagulant therapy. Rhinology 2004;42:82–97Google Scholar
24 Lam, AY, Elmer, GW, Mohutsky, MA. Possible interaction between warfarin and lycium barbarum L. Ann Pharmacother 2001;35:1199–201CrossRefGoogle ScholarPubMed
25 Wong, AL, Chan, TY. Interaction between warfarin and herbal product Quilinggao. Ann Pharmacother 2003;37:836–8CrossRefGoogle ScholarPubMed
26 Lambert, JP, Cormier, J. Potential interaction between warfarin and Boldo-fenugreek. Pharmacotherapy 2001;21:509–12CrossRefGoogle ScholarPubMed
27 Page, RL 2nd, Lawrence, JD. Potentiation of warfarin by dong quai. Pharmacotherapy 1999;19:870–6CrossRefGoogle ScholarPubMed
28 Yu, CM, Chan, JC, Sanderson, JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337–9CrossRefGoogle ScholarPubMed