Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-02T23:04:00.387Z Has data issue: false hasContentIssue false
  • English
  • Français

Papillary cystic oncocytoma and Warthin's tumor of the parotid gland

Published online by Cambridge University Press:  29 June 2007

P. A. Wackym ,
G. F. Gray Jr. ,
L. Rosenfeld  and
I. Friedmann
P. A. Wackym*
Affiliation:
Los Angeles, California and Nashville, Tennesse, U.S.A.
G. F. Gray Jr.
Affiliation:
Los Angeles, California and Nashville, Tennesse, U.S.A.
L. Rosenfeld
Affiliation:
Los Angeles, California and Nashville, Tennesse, U.S.A.
I. Friedmann
Affiliation:
Los Angeles, California and Nashville, Tennesse, U.S.A.
*
Reprint requests and correspondence to: Phillip Ashley Wackym, M.D., A7–130 CHS, UCLA Hospital, Los Angeles, CA 90024, U.S.A.
Get access Rights & Permissions [Opens in a new window]

Abstract

A 69-year-old white female had a left superficial parotidectomy for a papillary cystic oncocytoma. The histologic appearance was identical to Warthin's tumor except that it lacked a lymphoid component. This case suggests that the general morphology of a Warthin's tumor does not depend on the presence of lymphoid tissue or association with an intra-parotid lymph node. We reviewed 50 patients with Warthin's tumor to investigate the histogenesis of the lesion. We found that most Warthin's tumors (86%) appeared to be within lymph nodes, as indicated by the presence of a lymph node capsule or sinuses. The anatomy of intra-parotid lymph nodes in glands containing Warthin's tumors has been compared with that found in 11 parotid glands containing mucoepidermoid carcinomas. So-called heterotopic ductal inclusions may actually represent the normal intimate relationship of parotid gland to intra-parotid lymph nodes.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 6 , June 1986 , pp. 679 - 686
Copyright
Copyright © JLO (1984) Limited 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Albrecht, H. and Arzt, L. (1910) Beiträge zur Frage der Gewebsverirrung: Papilläre Cystandenome in Lymphdrüsen. Frankfurt Zeitschrift für Pathologie, 4: 47–69.Google Scholar
Batsakis, J. G. (1979) Tumors of the Head and Neck: Clinical and Pathological Considerations, ed 2. Baltimore, Williams & Wilkins, pp. 1–75.Google Scholar
Blanck, C., Eneroth, C-M. and Jakobsson, P. A. (1970) Oncocytoma of the parotid gland: Neoplasm or nodular hyperplasia?, Cancer, 25: 919–925.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Chapnik, J. S. (1983) The controversy of Warthin's tumor. Laryngoscope, 93: 695–716.CrossRefGoogle ScholarPubMed
Cohen, M. A. and Batsakis, J. G. (1968) Oncocytic tumors (oncocytomas) of minor salivary glands. Archives of Otolaryngology, 88: 97–99.Google ScholarPubMed
Cossman, J., Deegan, M. J. and Batsakis, J. G. (1977) Warthin tumor: B-lymphocytes within the lymphoid infiltrate. Archives of Pathology and Laboratory Medicine, 101: 354–356.Google ScholarPubMed
Diamond, L. W. and Braylan, R. C. (1979) Cell surface markers on lymphoid cells from Warthin's tumor. Cancer, 44: 580–583.3.0.CO;2-6>CrossRefGoogle Scholar
Fialkow, P. J., Jackson, C. E., Block, M. A. and Greenawald, K. A., (1977) Multicellular origin of parathyroid “adenomas”. New England Journal of Medicine, 297: 696–698.CrossRefGoogle ScholarPubMed
Gustafsson, H., Kjörell, U. and Carlosöö, B. (1985) Cytoskeletal proteins in oncocytic tumors of the parotid gland. Archives of Otolaryngology, 111: 99–105.CrossRefGoogle ScholarPubMed
Hsu, S-M., Hsu, P-L. and Nayak, R. N. (1981) Warthin's tumor: An immunohistochemical study of its lymphoid stroma. Human Pathology, 12: 251–257.CrossRefGoogle ScholarPubMed
Kroe, D. J., Pitcock, J. A. and Cocke, E. W. (1967) Oncocytic papillary cystadenoma of the larynx, Archives of Pathology, 84: 429–432.Google ScholarPubMed
Lennox, B., Timperley, W. R., Murray, D. and Kellett, H. S. (1968) Adenolymphoma-like tumours of the lacrimal caruncle and the larynx. Journal of Pathology and Bacteriology, 96: 321–326.CrossRefGoogle ScholarPubMed
Schiefer, H-G., Hubner, G. and Kleinsasser, O. (1968) Giant mitochondria from oncocytes of human adenolymphomas of the parotid gland: Isolation, morphological and biochemical investigations. Virchows Archiv Abt B Zellpathologie, 1: 230–239.CrossRefGoogle ScholarPubMed
Scott, R. E. and Florine, D. L. (1982) Cell cycle models for the aberrant coupling of growth arrest and differentiation in hyperplasia, metaplasia, and neoplasia. American Journal of Pathology, 107: 342–348.Google ScholarPubMed
Thompson, A. S. and Bryant, H. C. (1950) Histogenesis of papillary cystadenoma lymphomatosum (Warthin's tumor) of the parotid salivary gland. American Journal of Pathology, 26: 807–849.Google ScholarPubMed
Tubbs, R. R., Sheibani, K., Weiss, R. A., Lee, V., Sebek, B. A. and Valenzuela, R. (1980) Immunohistochemistry of Warthin's tumor. American Journal of Clinical Pathology, 74: 795–797.CrossRefGoogle ScholarPubMed
Warthin, A. S. (1929) Papillary cystadenoma lymphomatosum: A rare teratoid of the parotid region. Journal of Cancer Research, 13: 116–125.Google Scholar