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Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion

Published online by Cambridge University Press:  17 August 2015

D Mel-Hennawi  and
M R Ahmed
D Mel-Hennawi
Affiliation:
Otolaryngology Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
M R Ahmed*
Affiliation:
Otolaryngology Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
*
Address for correspondence: Dr Mohamed Rifaat Ahmed, Otolaryngology Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt Fax: +20 66 3415603 E-mail: [email protected]
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Abstract

Objective:

To compare the efficacy of two treatment regimens among Helicobacter pylori stool antigen positive children suffering from resistant otitis media with effusion.

Methods:

The study comprised 258 children with bilateral otitis media with effusion; 134 were positive for H pylori stool antigen, and were equally and randomly allocated to the control group or study group. The control group received standard otitis media with effusion therapy (amoxicillin and clavulanate), while the study group received standard H pylori triple therapy (clarithromycin, metronidazole and lansoprazole).

Results:

In the control group, there was a marked clinical response to treatment in 33 of the 67 children (49.3 per cent). In the study group, there was a marked response in a significantly higher number of children (46 out of 67, 68.7 per cent). The 124 H pylori stool antigen negative children not included in the 2 aforementioned groups received amoxicillin and clavulanate, and a marked response in symptoms was evident in 98 of these children (79 per cent).

Conclusion:

H pylori infection may lead to resistance to traditional otitis media with effusion treatment in some cases. H pylori eradication is associated with a high cure rate.

Keywords

Anti-Bacterial AgentsBacterial InfectionsOral Drug AdministrationCampylobacter PyloriOtitis Media
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 11 , November 2015 , pp. 1069 - 1072
Copyright
Copyright © JLO (1984) Limited 2015 

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References

1Youssef, TF, Ahmed, MR. Laser-assisted myringotomy versus conventional myringotomy with ventilation tube insertion in treatment of otitis media with effusion: long-term follow-up. Interv Med Appl Sci 2013;5:16–20Google ScholarPubMed
2Rosenfeld, RM, Schwartz, SR, Pynnonen, MA, Tunkel, DE, Hussey, HM, Fichera, JS et al. Clinical practice guideline: tympanostomy tubes in children. Otolaryngol Head Neck Surg 2013;149:S1–35CrossRefGoogle ScholarPubMed
3Paksoy, M, Altin, G, Eken, M, Hardal, U. Effectiveness of intratympanic dexamethasone in otitis media with effusion resistant to conventional therapy. Indian J Otolaryngol Head Neck Surg 2013;65:461–7CrossRefGoogle ScholarPubMed
4Lee, CH, Lee, JH, Kim, HM. Flexible integration of laser myringotomy and ventilation tube for bilateral otitis media with effusion: analysis of laser tympanostomy versus ventilation tube. PLoS One 2014;23:e84966Google Scholar
5Miura, MS, Mascaro, M, Rosenfeld, RM. Association between otitis media and gastroesophageal reflux: a systematic review. Otolaryngol Head Neck Surg 2012;146:345–52CrossRefGoogle ScholarPubMed
6Kotsis, GP, Nikolopoulos, TP, Yiotakis, IE, Papacharalampous, GX, Kandiloros, DC. Recurrent acute otitis media and gastroesophageal reflux disease in children. Is there an association? Int J Pediatr Otorhinolaryngol 2009;73:1373–80CrossRefGoogle ScholarPubMed
7Tasker, A, Dettmar, PW, Panetti, M, Koufman, JA, Birchall, JP, Pearson, JP. Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 2002;112:1930–4CrossRefGoogle ScholarPubMed
8Siupsinskiene, N, Jurgutaviciute, V, Katutiene, I, Janciauskas, D, Vaitkus, S, Adamonis, K. Helicobacter pylori infection in laryngeal diseases. Eur Arch Otorhinolaryngol 2013;270:2283–8CrossRefGoogle ScholarPubMed
9Moon, A, Solomon, A, Beneck, D, Cunningham-Rundles, S. Positive association between Helicobacter pylori and gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr 2009;49:283–8CrossRefGoogle ScholarPubMed
10Sullivan, PB, Thomas, JE, Wight, DG, Neale, G, Eastham, EJ, Corrah, T et al. Helicobacter pylori in Gambian children with chronic diarrhoea and malnutrition. Arch Dis Child 1990;65:189–91CrossRefGoogle ScholarPubMed
11Yilmaz, T, Ceylan, M, Akyön, Y, Ozçakýr, O, Gürsel, B. Helicobacter pylori: a possible association with otitis media with effusion. Otolaryngol Head Neck Surg 2006;134:772–7CrossRefGoogle ScholarPubMed
12Youssef, TF, Ahmed, MR. Treatment of clinically diagnosed laryngopharyngeal reflux disease. Arch Otolaryngol Head Neck Surg 2010;136:1089–92CrossRefGoogle ScholarPubMed
13Butler, CC, van Der Voort, JH. Steroids for otitis media with effusion: a systematic review. Arch Pediatr Adolesc Med 2001;155:641–7CrossRefGoogle ScholarPubMed
14Gessner, BD, Bruce, MG, Parkinson, AJ, Gold, BD, Muth, PT, Dunaway, E et al. A randomized trial of triple therapy for pediatric Helicobacter pylori infection and risk factors for treatment failure in a population with a high prevalence of infection. Clin Infect Dis 2005;41:1261–8CrossRefGoogle Scholar
15Olfat, FO, Zheng, Q, Oleastro, M, Voland, P, Boren, T, Karttunen, R et al. Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries. FEMS Immunol Med Microbiol 2005;44:151–6CrossRefGoogle ScholarPubMed
16Catrenich, CE, Makin, KM. Characterization of the morphologic conversion of Helicobacter pylori from bacillary to coccoid forms. Scand J Gastroenterol Suppl 1991;81:58–64CrossRefGoogle Scholar
17Glupczynski, Y, Burette, A, Labbe, M, Deprez, C, De Reuck, M, Deltenre, M. Campylobacter pylori-associated gastritis: a double-blind placebo-controlled trial with amoxycillin. Am J Gastroenterol 1988;83:365–72Google ScholarPubMed
18McCoul, ED, Goldstein, NA, Koliskor, B, Weedon, J, Jackson, A, Goldsmith, AJ. A prospective study of the effect of gastroesophageal reflux disease treatment on children with otitis media. Arch Otolaryngol Head Neck Surg 2011;137:35–41CrossRefGoogle ScholarPubMed
19Casswall, TH, Alfvén, G, Drapinski, M, Bergström, M, Dahlström, KA. One-week treatment with omeprazole, clarithromycin, and metronidazole in children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 1998;27:415–18CrossRefGoogle ScholarPubMed
20Marks, NJ, Mills, RP, Shaheen, OH. A controlled trial of cotrimoxazole therapy in serous otitis media. J Laryngol Otol 1981;95:1003–9CrossRefGoogle ScholarPubMed
21Marks, NJ, Mills, RP, Shaheen, OH. Cotrimoxazole in the treatment of serous otitis. A follow-up report. J Laryngol Otol 1983;97:213–15CrossRefGoogle ScholarPubMed