Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-14T13:22:15.325Z Has data issue: false hasContentIssue false
  • English
  • Français

Olfactory neuroblastoma: 14-year experience at an Australian tertiary centre and the role for longer-term surveillance

Published online by Cambridge University Press:  05 December 2016

C Schmidt ,
N Potter ,
S Porceddu  and
B Panizza
C Schmidt
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia School of Medicine, University of Queensland, Brisbane, Australia
N Potter
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia
S Porceddu
Affiliation:
School of Medicine, University of Queensland, Brisbane, Australia Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia
B Panizza*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia School of Medicine, University of Queensland, Brisbane, Australia
*
Address for correspondence: A/Prof Ben Panizza, Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba 4102, Brisbane, Australia Fax: (+61) 07 3176 2427 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Olfactory neuroblastoma is a rare sinonasal malignancy, with poorly defined treatment protocols. Management at a tertiary centre was retrospectively evaluated to inform future treatment and follow up.

Methods:

Cases treated with curative intent (2000–2014) were included. Data were collected, and overall and disease-free survival rates were calculated.

Results:

Eleven cases were identified, with a median follow up of 87 months. One patient was Kadish stage A, one was stage B, eight were stage C and one was stage D. The latter patient underwent chemoradiotherapy alone. The remaining patients proceeded to: endoscopic-assisted wide local excision (n = 2), anterior craniofacial resection (n = 4) or endoscopic craniofacial resection (n = 4). No patients had primary nodal disease or elective neck treatment. One patient had neoadjuvant chemoradiation. Six patients had post-operative radiotherapy; three received adjuvant chemotherapy. Two patients had late cervical node failure, and proceeded to neck dissection and post-operative radiotherapy. Two patients had late local recurrence. Ten-year overall and disease-free survival rates were 68.2 and 46.7 per cent, respectively.

Conclusion:

Longer-term follow up is supported given the incidence of late regional and local recurrence. Prophylactic treatment of cervical nodes in locally advanced disease is an area for further investigation.

Keywords

Olfactory NeuroblastomaEsthesioneuroblastomaSurveillanceRelapseSurvivalMetastasisNeoplasm
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Supplement S2: ASOHNS Supplement , July 2017 , pp. S29 - S34
Copyright
Copyright © JLO (1984) Limited 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Broich, G, Pagliari, A, Ottaviani, F. Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924. Anticancer Res 1997;17:2683–706Google Scholar
2 Petruzzelli, GJ, Howell, JB, Pederson, A, Origitano, TC, Byrne, RW, Munoz, L et al. Multidisciplinary treatment of olfactory neuroblastoma: patterns of failure and management of recurrence. Am J Otolaryngol 2015;36:547–53CrossRefGoogle ScholarPubMed
3 Rimmer, J, Lund, VJ, Beale, T, Wei, WI, Howard, D. Olfactory neuroblastoma: a 35-year experience and suggested follow-up protocol. Laryngoscope 2014;124:1542–9Google Scholar
4 Saade, RE, Hanna, EY, Bell, D. Prognosis and biology in esthesioneuroblastoma: the emerging role of Hyams grading system. Curr Oncol Rep 2015;17:423 Google Scholar
5 Kadish, S, Goodman, M, Wang, CC. Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer 1976;37:1571–6Google Scholar
6 Morita, A, Ebersold, MJ, Olsen, KD, Foote, RL, Lewis, JE, Quast, LM. Esthesioneuroblastoma: prognosis and management. Neurosurgery 1993;32:706–15Google Scholar
7 Dulguerov, P, Calcaterra, T. Esthesioneuroblastoma: the UCLA experience 1970–1990. Laryngoscope 1992;102:843–9CrossRefGoogle ScholarPubMed
8 Krischek, B, Godoy, BL, Zadeh, G, Gentili, F. From craniofacial resection to the endonasal endoscopic approach in skull base surgery. World Neurosurg 2013;80:56–8Google Scholar
9 Chao, KS, Kaplan, C, Simpson, JR, Haughey, B, Spector, GJ, Sessions, DG et al. Esthesioneuroblastoma: the impact of treatment modality. Head Neck 2001;23:749–57Google Scholar
10 Eich, HT, Hero, B, Staar, S, Micke, O, Seegenschmiedt, H, Mattke, A et al. Multimodality therapy including radiotherapy and chemotherapy improves event-free survival in stage C esthesioneuroblastoma. Strahlenther Onkol 2003;179:233–40Google Scholar
11 Devaiah, AK, Andreoli, MT. Treatment of esthesioneuroblastoma: a 16-year meta-analysis of 361 patients. Laryngoscope 2009;119:1412–16CrossRefGoogle ScholarPubMed
12 Bak, M, Wein, RO. Esthesioneuroblastoma: a contemporary review of diagnosis and management. Hematol Oncol Clin North Am 2012;26:1185–207Google Scholar
13 Fu, TS, Monteiro, E, Muhanna, N, Goldstein, DP, de Almeida, JR. Comparison of outcomes for open versus endoscopic approaches for olfactory neuroblastoma: a systematic review and individual participant data meta-analysis. Head Neck 2015;30:2306–16Google Scholar
14 Polin, RS, Sheehan, JP, Chenelle, AG, Munoz, E, Larner, J, Phillips, CD et al. The role of preoperative adjuvant treatment in the management of esthesioneuroblastoma: the University of Virginia experience. Neurosurgery 1998;42:1029–37Google Scholar
15 Zafereo, ME, Fakhri, S, Prayson, R, Batra, PS, Lee, J, Lanza, DC et al. Esthesioneuroblastoma: 25-year experience at a single institution. Otolaryngol Head Neck Surg 2008;138:452–8Google Scholar
16 Nalavenkata, SB, Sacks, R, Adappa, ND, Palmer, JN, Purkey, MT, Feldman, MD et al. Olfactory neuroblastoma: fate of the neck – a long-term multicenter retrospective study. Otolaryngol Head Neck Surg 2016;154:383–9Google Scholar
17 Kane, AJ, Sughrue, ME, Rutkowski, MJ, Aranda, D, Mills, SA, Buencamino, R et al. Posttreatment prognosis of patients with esthesioneuroblastoma. J Neurosurg 2010;113:340–51CrossRefGoogle ScholarPubMed
18 Tajudeen, BA, Arshi, A, Suh, JD, Palma-Diaz, MF, Bergsneider, M, Abemayor, E et al. Esthesioneuroblastoma: an update on the UCLA experience, 2002–2013. J Neurol Surg B Skull Base 2015;76:43–9Google Scholar
19 Bradley, PJ, Jones, NS, Robertson, I. Diagnosis and management of esthesioneuroblastoma. Curr Opin Otolaryngol Head Neck Surg 2003;11:112–18Google Scholar
20 Gruber, G, Laedrach, K, Baumert, B, Caversaccio, M, Raveh, J, Greiner, R. Esthesioneuroblastoma: irradiation alone and surgery alone are not enough. Int J Radiat Oncol Biol Phys 2002;54:486–91Google Scholar
21 Ganly, I, Patel, SG, Singh, B, Kraus, DH, Bridger, PG, Cantu, G et al. Complications of craniofacial resection for malignant tumors of the skull base: report of an International Collaborative Study. Head Neck 2005;27:445–51Google Scholar
22 Beitler, JJ, Fass, DE, Brenner, HA, Huvos, A, Harrison, LB, Leibel, SA et al. Esthesioneuroblastoma: is there a role for elective neck treatment? Head Neck 1991;13:321–6Google Scholar
23 Demiroz, C, Gutfeld, O, Aboziada, M, Brown, D, Marentette, LJ, Eisbruch, A. Esthesioneuroblastoma: is there a need for elective neck treatment? Int J Radiat Oncol Biol Phys 2011;81:255–61Google Scholar
24 Monroe, A, Hinerman, R, Amdur, R, Morris, C, Mendenhall, W. Radiation therapy for esthesioneuroblastoma: a rationale for elective neck irradiation. Head Neck 2003;23:529–34Google Scholar
25 De Bonnecaze, G, Chaput, B, Al Hawat, A, Filleron, T, Vairel, B, Serrano, E et al. Long-term oncological outcome after endoscopic surgery for olfactory esthesioneuroblastoma. Acta Otolaryngol 2014;134:1259–64Google Scholar