Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-23T13:01:21.075Z Has data issue: false hasContentIssue false

Modiolar ossification in paediatric patients with auditory neuropathy

Published online by Cambridge University Press:  15 May 2017

L Wang*
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, China
Z Wang
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, China
F Gao
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, China
K A Peng
Affiliation:
House Clinic, Los Angeles, California, USA
*
Address for correspondence: Dr Line Wang, Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 95th Yong'an Road, Xicheng District, Beijing 100050, People's Republic of China Fax: +1 213 784 5406 E-mail: [email protected]

Abstract

Objective:

To describe our finding of increased ossification of the modiolus in paediatric patients with auditory neuropathy who met criteria for cochlear implantation.

Methods:

A retrospective case series with a comparison group at a tertiary referral centre is described. Seven paediatric patients with auditory neuropathy who met criteria for and underwent cochlear implantation were identified. Fifteen paediatric implantees with bilateral profound sensorineural hearing loss were included as the comparison group. All patients underwent pre-operative computed tomography. Attenuation at the modiolus was measured in all subjects by a neuroradiologist blinded to clinical information.

Results:

Attenuation values in the modiolus in the auditory neuropathy patients (mean ± standard deviation = 796.2 ± 53.0 HU) was statistically significantly higher than in the comparison sensorineural hearing loss patients (267.1 ± 45.6 HU; p < 0.05, t-test).

Conclusion:

Patients with auditory neuropathy who meet criteria for cochlear implantation demonstrate significantly higher modiolar attenuation on computed tomography imaging, consistent with increased ossification at the modiolus.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Starr, A, Picton, TW, Sininger, Y, Hood, LJ, Berlin, CI. Auditory neuropathy. Brain 1996;119:741–53CrossRefGoogle ScholarPubMed
2 Starr, A, Sininger, YS, Pratt, H. The varieties of auditory neuropathy. J Basic Clin Physiol Pharmacol 2000;11:215–30CrossRefGoogle ScholarPubMed
3 McMahon, CM, Patuzzi, RB, Gibson, WP, Sanli, H. Frequency-specific electrocochleography indicates that presynaptic and postsynaptic mechanisms of auditory neuropathy exist. Ear Hear 2008;29:314–25CrossRefGoogle ScholarPubMed
4 Tavartkiladze, GA. Auditory neuropathy (auditory neuropathy spectrum disorders): the approaches to diagnostics and rehabilitation [in Russian]. Vestn Otorinolaringol 2014;(2):916 Google ScholarPubMed
5 Madden, C, Rutter, M, Hilbert, L, Greinwald, JH Jr, Choo, DI. Clinical and audiological features in auditory neuropathy. Arch Otolaryngol Head Neck Surg 2002;128:1026–30CrossRefGoogle ScholarPubMed
6 Madden, C, Hilbert, L, Rutter, M, Greinwald, J, Choo, D. Pediatric cochlear implantation in auditory neuropathy. Otol Neurotol 2002;23:163–8CrossRefGoogle ScholarPubMed
7 Naganawa, S, Ito, T, Iwayama, E, Fukatsu, H, Ishigaki, T, Nakashima, T et al. MR imaging of the cochlear modiolus: area measurement in healthy subjects and in patients with a large endolymphatic duct and sac. Radiology 1999;213:819–23CrossRefGoogle ScholarPubMed
8 Shapiro, SM, Nakamura, H. Bilirubin and the auditory system. J Perinatol 2001;21(suppl 1):S52–5; discussion S59–62CrossRefGoogle ScholarPubMed
9 Saluja, S, Agarwal, A, Kler, N, Amin, S. Auditory neuropathy spectrum disorder in late preterm and term infants with severe jaundice. Int J Pediatr Otorhinolaryngol 2010;74:1292–7CrossRefGoogle ScholarPubMed
10 Baradaranfar, MH, Atighechi, S, Dadgarnia, MH, Jafari, R, Karimi, G, Mollasadeghi, A et al. Hearing status in neonatal hyperbilirubinemia by auditory brain stem evoked response and transient evoked otoacoustic emission. Acta Med Iran 2011;49:109–12Google ScholarPubMed
11 Silva, DP, Martins, RH. Analysis of transient otoacoustic emissions and brainstem evoked auditory potentials in neonates with hyperbilirubinemia. Braz J Otorhinolaryngol 2009;75:381–6CrossRefGoogle ScholarPubMed
12 Nickisch, A, Massinger, C, Ertl-Wagner, B, von Voss, H. Pedaudiologic findings after severe neonatal hyperbilirubinemia. Eur Arch Otorhinolaryngol 2009;266:207–12CrossRefGoogle ScholarPubMed
13 Suga, F, Lindsay, JR. Labyrinthitis ossificans. Ann Otol Rhinol Laryngol 1977;86:1729 CrossRefGoogle ScholarPubMed
14 Green, JD Jr, Marion, MS, Hinojosa, R. Labyrinthitis ossificans: histopathologic consideration for cochlear implantation. Otolaryngol Head Neck Surg 1991;104:320–6CrossRefGoogle ScholarPubMed
15 Trautwein, PG, Sininger, YS, Nelson, R. Cochlear implantation of auditory neuropathy. J Am Acad Audiol 2000;11:309–15Google ScholarPubMed
16 Shallop, JK, Peterson, A, Facer, GW, Fabry, LB, Driscoll, CL. Cochlear implants in five cases of auditory neuropathy: postoperative findings and progress. Laryngoscope 2001;111:555–62CrossRefGoogle ScholarPubMed
17 Miyamoto, RT, Kirk, KI, Renshaw, J, Hussain, D. Cochlear implantation in auditory neuropathy. Laryngoscope 1999;109:181–5CrossRefGoogle ScholarPubMed
18 Walton, J, Gibson, WP, Sanli, H, Prelog, K. Predicting cochlear implant outcomes in children with auditory neuropathy. Otol Neurotol 2008;29:302–9CrossRefGoogle ScholarPubMed