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Mitochondrial neurogastrointestinal encephalomyopathy associated with progressive hearing loss

Published online by Cambridge University Press:  15 June 2010

N Hiraki ,
T Udaka ,
H Yamamoto ,
Y Kadokawa ,
J Ohkubo  and
H Suzuki
N Hiraki*
Affiliation:
Department of Otorhinolaryngology, Hamamatsu Rosai Hospital, Hamamatsu, Japan
T Udaka
Affiliation:
Department of Otorhinolaryngology, Kumamoto Rosai Hospital, Yatsushiro, Japan
H Yamamoto
Affiliation:
Department of Otorhinolaryngology, Hamamatsu Rosai Hospital, Hamamatsu, Japan
Y Kadokawa
Affiliation:
Department of Otorhinolaryngology, Kumamoto Rosai Hospital, Yatsushiro, Japan
J Ohkubo
Affiliation:
School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
H Suzuki
Affiliation:
School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
*
Address for correspondence: Dr Nobuaki Hiraki, Department of Otorhinolaryngology, Hamamatsu Rosai Hospital, 25 Shogen-town, Naka-ku, Hamamatsu, 430-8525, Japan. Fax: +81 53 465 4380 E-mail: [email protected]
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Abstract

Objective:

We report a rare case of mitochondrial neurogastrointestinal encephalomyopathy with hearing loss.

Case report:

A 46-year-old woman presented with a three-year history of progressive, bilateral hearing loss and tinnitus. She had been suffering from unexplained abdominal pain and diarrhoea for 20 years. When first seen, her otoscopic findings were normal, and pure tone audiometry showed mild and moderate hearing loss in her right and left ears, respectively. She also had: bilateral ophthalmoparesis, neck and limb muscle weakness, and hypoactive deep tendon reflexes on neurological examination; diffuse leukoencephalopathy on magnetic resonance imaging of the brain; and markedly reduced leukocyte thymidine phosphorylase activity. On the basis of these findings, the patient was diagnosed with mitochondrial neurogastrointestinal encephalomyopathy.

Conclusion:

Mitochondrial neurogastrointestinal encephalomyopathy is an autosomal recessive disease caused by mutation of the thymidine phosphorylase gene, and is characterised by ophthalmoparesis, peripheral neuropathy, leukoencephalopathy, gastrointestinal symptoms and abnormal mitochondria in muscle cells. Current advances in genetic research may reveal a higher prevalence of mitochondrial disorders than had previously been thought. Otolaryngologists should be aware of mitochondrial neurogastrointestinal encephalomyopathy and other rare genetic disorders when managing patients with progressive hearing loss.

Keywords

Mitochondrial Neurogastrointestinal EncephalomyopathySensorineural Hearing LossThymidine Phosphorylase
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 9 , September 2010 , pp. 1007 - 1009
Copyright
Copyright © JLO (1984) Limited 2010

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