Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-07T23:01:21.653Z Has data issue: false hasContentIssue false
  • English
  • Français

Long-term safety and efficacy study of intranasal ipratroprium bromide

Published online by Cambridge University Press:  29 June 2007

C. A. Milford ,
T. A. Mugliston ,
V. J. Lund  and
I. S. Mackay
C. A. Milford*
Affiliation:
London
T. A. Mugliston
Affiliation:
London
V. J. Lund
Affiliation:
London
I. S. Mackay
Affiliation:
London
*
C. A. Milford F.R.C.S. ENT DepartmentCharing Cross HospitalFulham Palace RoadLondon W6 8RF
Get access Rights & Permissions [Opens in a new window]

Abstract

Forty patients presenting with watery rhinorrhoea as their main complaint were entered in an open trial of long-term intranasal ipratroprium bromide. Fourteen of these (35 per cent) found it to be beneficial and completed one year of treatment. Side-effects were seen in 28 patients (70 per cent) but these were local and mild in nature. All resolved during the trial as patients adjusted the dosage to individual severity and frequency of symptoms. No significant systemic effects were noted during the course of therapy. Ipratroprium is a useful drug in the treatment of watery rhinorroea and appears safe for long-term use.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 2 , February 1990 , pp. 123 - 125
Copyright
Copyright © JLO (1984) Limited 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Borum, P., Mygind, N. and Schultz Larsen, F. (1979) Intranasal ipratroprium: A new treatment for perennial rhinitis. Clinical Otolaryngology, 4: 407–411.CrossRefGoogle Scholar
Borum, P., Mygind, N. and Schultz Larsen, F. (1983) Ipratroprium treatment for rhinorrhoea in patients with perennial rhinitis. An open follow-up study of efficacy and safety. Clinical Otolaryngology, 8: 267–272.CrossRefGoogle Scholar
Borura, P., Schultz Larsen, F. and Mygind, N. (1979) Nasal methacholine provocation and ipratroprium therapy of perennial rhinitis. Acta Otolaryngologica, 360: 35–39.Google Scholar
Malmberg, H., Grahne, B., Holopainen, E. and Binder, E. (1983) Ipratroprium (atrovent) in the treatment of vasomotor rhinitis of elderly patients. Clinical Otolaryngology, 8: 273–276.CrossRefGoogle Scholar
Mygind, N. and Weeke, B. (1986) Allergic and vasomotor rhinitis: Clinical aspects. Munksgaard, Copenhagen.Google Scholar
Von Haacke, N. P., Moore Gillon, V. and Capel, L. H. (1983). Double-blind cross over trial of ipratropriura and placebo in chronic rhinorrhoea. British Medical Journal, 287: 1258–1259.CrossRefGoogle ScholarPubMed