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Long-term effects of intratympanic methylprednisolone perfusion treatment on intractable Ménière's disease

Published online by Cambridge University Press:  06 February 2015

W She ,
L Lv ,
X Du ,
H Li ,
Y Dai ,
L Lu ,
X Ma  and
F Chen
W She*
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China
L Lv
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Huai'an First People's Hospital, Nanjing Medical University, Jiangsu, China
X Du
Affiliation:
Hough Ear Institute, Oklahoma City, Oklahoma, USA
H Li
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China
Y Dai
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China
L Lu
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China
X Ma
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China
F Chen
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China
*
Address for correspondence: Dr W She, Department of Otolaryngology–Head and Neck Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China Fax: 86–25–83317016 E-mail: [email protected]
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Abstract

Objective:

This study aimed to investigate the long-term efficacy of intratympanic methylprednisolone perfusion treatment for intractable Ménière's disease.

Methods:

A retrospective analysis of 17 intractable Ménière's disease patients treated with intratympanic methylprednisolone perfusion was performed. Treatment efficacy was evaluated according to the American Academy of Otolaryngology–Head and Neck Surgery criteria. Short and long-term control or improvement rates were calculated after 6 and 24 months, respectively.

Results:

Sixteen patients were followed for more than two years. Short- and long-term vertigo control rates were 94 per cent and 81 per cent, respectively; short- and long-term functional activity improvements were 94 per cent and 88 per cent, respectively. The pure tone average was 53 ± 14 dB before treatment, and 50 ± 16 dB at 6 months and 52 ± 20 dB at 24 months after intratympanic methylprednisolone perfusion. Tinnitus was controlled or improved in five patients over the two-year follow-up period.

Conclusion:

Intratympanic methylprednisolone perfusion can effectively control vertigo and improve functional activity in intractable Ménière's disease patients with good hearing preservation. It may therefore be a viable alternative treatment for intractable Ménière's disease.

Keywords

Ménière's diseaseMethylprednisolonePerfusionTympanum
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 3 , March 2015 , pp. 232 - 237
Copyright
Copyright © JLO (1984) Limited 2015 

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