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Is otosclerosis a generalized connective tissue disorder?

Biophysical and biochemical studies of skin biopsies from patients with otosclerosis

Published online by Cambridge University Press:  29 June 2007

H. Oxlund ,
U. Pedersen ,
C. C. Danielsen ,
I. Oxlund  and
O. Elbrønd
H. Oxlund*
Affiliation:
Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark.
U. Pedersen
Affiliation:
Department of Otorhinolaryngology, Aarhus Kommunehospital, University of Aarhus, DK-8000 Aarhus, Denmark.
C. C. Danielsen
Affiliation:
Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark.
I. Oxlund
Affiliation:
Department of Otorhinolaryngology, Aarhus Kommunehospital, University of Aarhus, DK-8000 Aarhus, Denmark.
O. Elbrønd
Affiliation:
Department of Otorhinolaryngology, Aarhus Kommunehospital, University of Aarhus, DK-8000 Aarhus, Denmark.
*
Mr. Hans Oxlund, M.D., Ph.D., Chairman, Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark.
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Abstract

It has been suggested that otosclerosis might be caused by a generalized disorder in the connective tissue.

The biophysical and biochemical properties of skin biopsies from twelve patients with otosclerosis and twelve age- and sex-matched controls were investigated. No differences were found in skin strength and extensibility, skin thickness, collagen content, the relationship between collagen type I and type III, reducible collagen cross-links and molecular stability of collagen type I of samples from patients with otosclerosis as compared with those from the controls. The present study does not support the suggestion that otosclerosis might be a generalized connective tissue disorder.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 101 , Issue 4 , April 1987 , pp. 307 - 311
Copyright
Copyright © JLO (1984) Limited 1987

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