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Immunopathology of olfactory mucosa following injury to the olfactory bulb

Published online by Cambridge University Press:  29 June 2007

Mayumi Inamitsu ,
Tadashi Nakashima  and
Takuya Uemura
Mayumi Inamitsu*
Affiliation:
Fukuoka, Japan
Tadashi Nakashima
Affiliation:
Fukuoka, Japan
Takuya Uemura
Affiliation:
Fukuoka, Japan
*
Department of Otolaryngology, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812, Japan.
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Abstract

Removal of the olfactory bulb was performed on rats in an attempt to elucidate the processes of olfactory dysfunction following head injury. Degeneration and regeneration of the olfactory mucosa were examined, histopathologically and immunohistochemically. We used antisera to olfactory marker protein (OMP) and neuron specific enolase (NSE) as a marker of the mature olfactory receptor neurons. Following rapid degeneration after bulbectomy, the olfactory receptor neurons regenerated. OMP and NSE containing cells re-appeared 49 days later. However, the cell population of the neuroepithelium did not revert to the numbers observed in the non-operated neuroepithelium, even three months later. The lack of a connection between regenerated axons and the olfactory bulb may result in immature neuronal replacement and reduce the number of olfactory receptor neurons.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 12 , December 1990 , pp. 959 - 964
Copyright
Copyright © JLO (1984) Limited 1990

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