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Human papilloma virus prevalence in laryngeal squamous cell carcinoma

Published online by Cambridge University Press:  26 February 2007

A Gungor ,
H Cincik ,
H Baloglu ,
E Cekin ,
S Dogru  and
E Dursun
A Gungor
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
H Cincik*
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
H Baloglu
Affiliation:
Department of Pathology, Gulhane military medical academy, Haydarpasa Educational Hospital, Istanbul, Turkey.
E Cekin
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
S Dogru
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
E Dursun
Affiliation:
Department of Otolaryngology, Haydarpasa Educational Hospital, Istanbul, Turkey
*
Address for correspondence: Dr Hakan Cincik, GATA Haydarpasa Egitim Hastanesi KBB Klinigi, Kadıkoy 34668, Istanbul, Türkiye. Fax: +90 216 348 78 80 E-mail: [email protected]
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Abstract

Purpose:

To determine the prevalence and type of human papilloma virus deoxyribonucleic acid (DNA) in cases of laryngeal squamous cell carcinoma.

Methods:

We analysed the prevalence of human papilloma virus infection in archived paraffin block specimens taken from 99 cases of laryngeal squamous cell carcinoma between 1990 and 2005, using polymerase chain reaction techniques. Biopsy specimens from five proven verrucous skin lesions were used as positive controls, and peripheral blood samples from five healthy volunteers were used as negative controls.

Results:

Four test samples were found to have inadequate deoxyribonucleic acid purity and were therefore excluded from the study. Human papilloma virus deoxyribonucleic acid was detected in seven of 95 cases of laryngeal squamous cell carcinoma (7.36 per cent). Human papilloma virus genotyping revealed double human papilloma virus infection in three cases and single human papilloma virus infection in the remaining four cases. The human papilloma virus genotypes detected were 6, 11 and 16 (the latter detected in only one case).

Conclusion:

In our series, a very low human papilloma virus prevalence was found among laryngeal squamous cell carcinoma cases. The human papilloma virus genotypes detected were mostly 6 and/or 11, and 16 in only one case. To the best of our knowledge, this is the first report of human papilloma virus prevalence in laryngeal squamous cell carcinoma, based on polymerase chain reaction genotyping in a Turkish population.

Keywords

Human Papilloma VirusLaryngeal NeoplasmsPapillomas
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 121 , Issue 8 , August 2007 , pp. 772 - 774
Copyright
Copyright © JLO (1984) Limited 2007

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