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Human papilloma virus and carcinoma of the laryngopharynx

Published online by Cambridge University Press:  29 June 2007

D. W. Morgan ,
V. Abdullah ,
R. Quiney  and
S. Myint
D. W. Morgan*
Affiliation:
The Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London WC1X 8DA.
V. Abdullah
Affiliation:
The Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London WC1X 8DA.
R. Quiney
Affiliation:
London
S. Myint
Affiliation:
Department of Medical Microbiology. UCMSM, London Current address: Department of Microbiology, University of Leicester, UK.
*
D. W. Morgan, F.R.C.S., Royal Berkshire Hospital, London Road, Reading, Berkshire RG1 5AN.
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Abstract

The presence of human papillomavirus (HPV) genomes 6, 11, 16 and 33 in 16 patients with laryngopharyngeal carcinomas was examined by means of a polymerase chain reaction. HPV genomes were detected in 75 per cent of cases. In hypopharyngeal carcinoma, HPV 6 and 11 were present in adjacent tissue but absent from the tumour. HPV 16 and 33 were present in 40 per cent of laryngeal tumours and adjacent tissue. These results suggest that HPV 16 and 33 may be closely associated with the development of some laryngopharyngeal carcinomas.

Keywords

Papillomavirus (human)Laryngeal neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 4 , April 1991 , pp. 288 - 290
Copyright
Copyright © JLO (1984) Limited 1991

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