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Human endolymphatic sac: possible mechanisms of pressure regulation

Published online by Cambridge University Press:  29 June 2007

Phillip Ashley Wackym ,
Ulla Friberg ,
Dan Bagger-Sjöbäck ,
Fred H. Linthicum Jr ,
Imrich Friedmann  and
Helge Rask-Andersen
Phillip Ashley Wackym*
Affiliation:
Division of Head and Neck Surgery (Otolaryngology), UCLA School of Medicine, Los Angeles (Dr. Wackym); House Ear Institute, Los Angeles (Drs. Wackym, Friedmann and Linthicum); Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden (Drs. Friberg and Rask-Andersen); and the Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden (Dr. Bagger-Sjöbäck).
Ulla Friberg
Affiliation:
Division of Head and Neck Surgery (Otolaryngology), UCLA School of Medicine, Los Angeles (Dr. Wackym); House Ear Institute, Los Angeles (Drs. Wackym, Friedmann and Linthicum); Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden (Drs. Friberg and Rask-Andersen); and the Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden (Dr. Bagger-Sjöbäck).
Dan Bagger-Sjöbäck
Affiliation:
Division of Head and Neck Surgery (Otolaryngology), UCLA School of Medicine, Los Angeles (Dr. Wackym); House Ear Institute, Los Angeles (Drs. Wackym, Friedmann and Linthicum); Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden (Drs. Friberg and Rask-Andersen); and the Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden (Dr. Bagger-Sjöbäck).
Fred H. Linthicum Jr
Affiliation:
Division of Head and Neck Surgery (Otolaryngology), UCLA School of Medicine, Los Angeles (Dr. Wackym); House Ear Institute, Los Angeles (Drs. Wackym, Friedmann and Linthicum); Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden (Drs. Friberg and Rask-Andersen); and the Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden (Dr. Bagger-Sjöbäck).
Imrich Friedmann
Affiliation:
Division of Head and Neck Surgery (Otolaryngology), UCLA School of Medicine, Los Angeles (Dr. Wackym); House Ear Institute, Los Angeles (Drs. Wackym, Friedmann and Linthicum); Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden (Drs. Friberg and Rask-Andersen); and the Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden (Dr. Bagger-Sjöbäck).
Helge Rask-Andersen
Affiliation:
Division of Head and Neck Surgery (Otolaryngology), UCLA School of Medicine, Los Angeles (Dr. Wackym); House Ear Institute, Los Angeles (Drs. Wackym, Friedmann and Linthicum); Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden (Drs. Friberg and Rask-Andersen); and the Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden (Dr. Bagger-Sjöbäck).
*
Phillip Ashley Wackym, M.D., A7-130 CHS, UCLA Hospital, Los Angeles, California 90024, U.S.A.
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Abstract

The ultrastructure of the normal human endolymphatic sac (ES) has been observed by transmission electron microscopy (TEM). The role of the epithelium, the various regions of the subepithelial space and the general anatomy of the ES in pressure regulation were morphologically studied to generate testable hypotheses of human ES function. Light microscopic (LM) and TEM evidence of pressure regulatory mechanisms by endolymph resorption, mechanical factors, and secretory activity are presented. These mechanisms may be useful in designing experimental studies of the ES, and in interpretation of retrospective LM and TEM studies of patients with Meniere's disease.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 101 , Issue 8 , August 1987 , pp. 768 - 779
Copyright
Copyright © JLO (1984) Limited 1987

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References

Adlington, P. (1984) The saccus endolymphaticus in the rabbit. Further studies. Journal of Laryngology and Otology, 98: 857–877.CrossRefGoogle ScholarPubMed
Allen, G. W. (1964) Endolymphatic sac and cochlear aqueduct. Their role in the regulation of labyrinthine pressures. Archives of Otolaryngology, 79: 322–327.CrossRefGoogle ScholarPubMed
Antunez, J. -C. M., Galey, F. R., Linthicum, F. H. and McCann, G. D. (1980) Computer-aided and graphic reconstruction of the human endolymphatic duct and sac. A method for comparing Menièere's and non-Menière's disease cases. Annals of Otology, Rhinology and Laryngology, 89 (Supplement 76): 23–32.CrossRefGoogle Scholar
Arenberg, I. K., Murray, J. P., Rauchbach, E. and Schenck, N. L. (1976) An experimental model for the study of endolymphatic hydrops in sharks: Implications for the clinician. Laryngoscope, 86: 1426–1434.CrossRefGoogle Scholar
Arenberg, I. K., Norback, D. H. and Shambaugh, G. E. (1982) Ultrastructural analysis of endolymphatic sac biopsies. Biopsy technique and identification of endolymphatic sac epithelium. Archives of Otolaryngology, 108: 292–298.CrossRefGoogle Scholar
Bagger-Sjöbäck, D., Friberg, U. and Rask-Andersen, H. (1986) Human endolymphatic sac: An ultrastructural study. Archives of Otolaryngology, 112: 398–409.CrossRefGoogle ScholarPubMed
Dohlman, G. F. (1965) The mechanism of secretion and absorption of endolymph in the vestibular apparatus. Acta Otolaryngologica, 59: 275–288.CrossRefGoogle Scholar
Friberg, U., Rask-Andersen, H. and Bagger-Sjöbäck, D. (1984) Human endolymphatic duct: An ultra-structural study. Archives of Otolaryngology, 110: 421–428.CrossRefGoogle Scholar
Gussen, R. (1974) Menière syndrome. Compensatory collateral venous drainage with endolymphatic sac fibrosis. Archives of Otolaryngology, 99: 414–418.CrossRefGoogle ScholarPubMed
Gussen, R. (1982) Vascular mechanisms in Menieres disease. Theoretical considerations. Archives of Otolaryngology, 108: 544–549.CrossRefGoogle ScholarPubMed
Juhn, S. K. (1984) Inner ear fluid dynamics and endolymphatic hydrops. Acta Otolaryngologica, Supplement, 406: 26–30.Google ScholarPubMed
Kaye, I. G., Wheeler, H. O., Whitlock, R. T. and Lane, N. (1966) Fluid transport in the rabbit gallbladder: A combined physiological and electron microscopic study. Journal of Cell Biology, 30: 237–268.CrossRefGoogle ScholarPubMed
Kimura, R. S. (1976) Experimental pathogenesis of hydrops. Archives of Otolaryngology, 212: 263–275.Google ScholarPubMed
Kishimoto, S., Nagahara, K., Fisch, U. and Dillier, N. (1983) Inner ear pressure measurements. Effects of obstruction of the cochlear aqueduct and endolymphatic duct on the perilymphatic pressure. Otolaryngologic Clinics of North America, 16(1): 21–35.CrossRefGoogle ScholarPubMed
Koberg, E., Haubrich, J. and Kernbach, B. (1967) Autoradiographische utersuchungen zum stoff-wechsel des ductus und saccus endolymphaticus. Acta Otolaryngologica, 64: 146–156.CrossRefGoogle Scholar
Lundquist, P. -G. (1965) The endolymphatic duct and sac in the guinea pig. An electron microscopic and experimental investigation. Acta Otolaryngologica, Supplement, 201: 1–108.Google Scholar
Lundquist, P. -G. (1976) Aspects of endolymphatic sac morphology and function. Archives of Otorhinolaryngology, 212: 231–240.CrossRefGoogle ScholarPubMed
McComb, J. G. (1983) Recent research into the nature of cerebrospinal fluid formation and absorption. Journal of Neurosurgery, 59: 369–383.CrossRefGoogle ScholarPubMed
Morgenstern, C., Miyamoto, H., Arnold, W. and Vosteen, K. -H. (1982) Functional and morphological findings of endolymphatic sac. Acta Otolaryngologica, 93: 187–194.CrossRefGoogle ScholarPubMed
Rask-Andersen, H., Bredberg, G., Lyttkens, L. and Lööf, G. (1981a) The function of the endolymphatic duct—an experimental study using ionic lanthanum as a tracer: A preliminary report. Annals of the New York Academy of Science, 374: 11–19.CrossRefGoogle ScholarPubMed
Rask-Andersen, H., Bredberg, G. and Stahle, J. (1981b) Structure and function of the endolympha-tic duct, in Vosteen, K-H et al. (eds.): Menière's Disease: Pathogenesis, Diagnosis and Treatment. Stuttgart, Georg Thieme Verlag, pp. 99–109.Google Scholar
Sando, I. and Ikeda, M. (1984) The vestibular aqueduct in patients with Menière's disease. A temporal bone histopathological investigation. Acta Otolaryngologica, 97: 558–570.CrossRefGoogle ScholarPubMed
Schindler, R. A., Horn, K. L. and Maglio, M. (1979) The ultrastructure of the endolymphatic sac in Menière's disease. Laryngoscope, 89: 95–107.CrossRefGoogle ScholarPubMed
Secretan, J. P. (1944) De l'histologie normale du sac endolymphatique chez l'homme. Acta Otolaryngologica, 32: 119–163.CrossRefGoogle Scholar
Silverstein, H. (1966) Biochemical and physiological studies of the endolymphatic sac in the cat. Laryngoscope, 76: 498–512.CrossRefGoogle Scholar
Teichmann, I., Vigh, B. and Aros, B. (1964) Histo-chemical studies on Gomori-positive substance in the endolymphatic sac of the rat. I. Examination of the Gomori-positive substance in the endolymphatic sac of the rat. Acta Biologica Hungary, 14(4): 293–300.Google Scholar
Tripathi, R. C. (1977) The aqueous outflow pathway in vertebrate eyes, in Perkins, E. S., Hill, D. W. (eds. ): Scientific Foundations of Ophthalmology. London, William Heinemann Medical Books Ltd., pp. 1–7.Google Scholar
Wilbrand, H. F., Rask-Andersen, H. and Gilstring, D. (1974) The vestibular aqueduct and the paravestibular canal. An anatomic and roentgenologic investigation. Acta Radiologica, 15: 337–355.CrossRefGoogle ScholarPubMed
Yoo, T. J., Yazawa, Y., Tomoda, K. and Floyd, R. (1983) Type II collagen-induced autoimmune endolymphatic hydrops in guinea pig. Science, 222 (4619): 65–67.CrossRefGoogle ScholarPubMed