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Efficacy of low-dose intratympanic dexamethasone as a salvage treatment for idiopathic sudden sensorineural hearing loss: the Modbury Hospital experience

Published online by Cambridge University Press:  24 January 2014

S Oue ,
J Jervis-Bardy ,
L Stepan ,
S Chong  and
C-K L Shaw
S Oue*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Modbury Hospital, Adelaide, South Australia, Australia
J Jervis-Bardy
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Modbury Hospital, Adelaide, South Australia, Australia
L Stepan
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Modbury Hospital, Adelaide, South Australia, Australia
S Chong
Affiliation:
Division of Surgery, University of Adelaide, South Australia, Australia
C-K L Shaw
Affiliation:
Division of Surgery, University of Adelaide, South Australia, Australia
*
Address for correspondence: Ms Sakiko Oue, Department of Otolaryngology Head and Neck Surgery, Modbury Hospital, 41–69 Smart Rd, Modbury, SA 5092, Australia Fax: +61 (08) 8161 2685 E-mail: [email protected]
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Abstract

Objective:

To evaluate the efficacy of low-dose intratympanic dexamethasone therapy in patients with idiopathic sudden sensorineural hearing loss whose hearing in the affected ear had failed to improve following a course of oral steroid therapy.

Methods:

A prospective pilot study was undertaken of eight patients with idiopathic sudden sensorineural hearing loss whose hearing had failed to improve after a course of prednisolone. These patients subsequently received 8 mg intratympanic dexamethasone therapy, delivered via a ventilation tube on a weekly basis for 1 month. Clinical outcome was assessed weekly with pure tone audiography.

Results:

At the end of the 1-month treatment period, no significant hearing improvement was observed on pure tone audiography in any of the patients (i.e. improvements were all less than 10 dB).

Conclusion:

The response to 8 mg of intratympanic dexamethasone used as a salvage therapy for idiopathic sudden sensorineural hearing loss was inadequate. A higher dosage of intratympanic dexamethasone might be required to achieve better outcomes.

Keywords

Hearing Loss, SensorineuralDexamethasoneTreatment
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue S2 , July 2014 , pp. S27 - S30
Copyright
Copyright © JLO (1984) Limited 2014 

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Footnotes

Presented at the Australian Society of Otolaryngology Head and Neck Surgery Annual Scientific Meeting, 19 March 2013, Perth, Western Australia, Australia

References

1Mattox, DE, Simmons, FB. Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 1997;86:463–80CrossRefGoogle Scholar
2Conlin, AE, Parnes, LS. Treatment of sudden sensorineural hearing loss, I: A systemic review. Arch Otolaryngol Head Neck Surg 2007;133:573–81CrossRefGoogle Scholar
3Haynes, DS, O'Malley, M, Cohen, S, Watford, K, Labadie, RF. Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy. Laryngoscope 2007;117:3–15Google Scholar
4Conlin, AE, Parnes, LS. Treatment of sudden sensorineural hearing loss, II: a meta-analysis. Arch Otolaryngol Head Neck Surg 2007;133:582–6Google Scholar
5Shaia, FT, Sheehy, JL. Sudden sensori-neural hearing impairment; a report of 1220 cases. Laryngoscope 1976;86:389–98CrossRefGoogle Scholar
6Stachler, RJ, Chandrasekhar, SS, Archer, SM, Rosenfeld, RM, Schwartz, SR, Barrs, DM et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg 2012;146:1–35Google Scholar
7Parnes, LS, Sun, AH, Freeman, DJ. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 1999;109:1–17CrossRefGoogle ScholarPubMed
8Kosyakov, S, Atanesyan, A, Gunenkov, A, Ashkhatunyan, E, Kurlova, A. Intratympanic steroids for sudden sensorineural hearing loss. Int Adv Otol 2011;7:323–32Google Scholar
9Ho, HG, Lin, HC, Shu, MT, Yang, CC, Tsai, HT. Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment. Laryngoscope 2004;114:1184–9Google Scholar
10Xenellis, J, Papadimitriou, N, Nikolopoulos, T, Maragoudakis, P, Segas, J, Tzagaroulakis, A et al. Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: control study. Otolaryngol Head Neck Surg 2006;134:940–5CrossRefGoogle ScholarPubMed