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Effect of topical mometasone furoate on adenoidal lymphoid tissue: a light microscopic study

Published online by Cambridge University Press:  08 January 2019

M R Ahmed ,
A S Abou-Halawa ,
I H Ibrahim ,
R F Zittoon  and
E F Y Makary
M R Ahmed*
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
A S Abou-Halawa
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
I H Ibrahim
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
R F Zittoon
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
E F Y Makary
Affiliation:
Department of Histology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
*
Author for correspondence: Prof Mohamed Rifaat Ahmed, Department of Otolaryngology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt E-mail: [email protected]
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Abstract

Background

Adenoid hypertrophy is a common cause of upper airway obstruction, and adenoidectomy is one of the most frequently performed operations in children. Topical nasal steroids can act directly on nasopharyngeal lymphoid tissue to decrease its reactive inflammatory changes and potentially reduce its size.

Objective

To study the light microscopic changes in adenoidal lymphoid tissue after one month of topical steroid use.

Methods

Twenty-six children with adenoid hypertrophy grade 3 scheduled for adenoidectomy were randomly divided into two equal groups: one group received mometasone furoate aqueous nasal spray (Nasonex) 100 mcg/day for four weeks, and a control group received nasal normal saline 0.9 per cent for four weeks. The removed adenoids were examined histopathologically.

Results

Adenoidal tissue from the mometasone group had less reactive germinal centres and less spongiosis compared to the control group. The latter showed proliferating, reactive, variable sized and shaped lymphoid follicles, with congested blood vessels in the interfollicular areas.

Conclusion

The use of intranasal mometasone furoate aqueous nasal spray (Nasonex) for one month reduced adenoidal tissue reactive cellular changes and its vascularity. This is, however, a pilot study; a longer treatment period is needed to assess the effect of treatment on adenoidal size.

Keywords

AdenoidsMometasoneMicroscopyPathology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 2 , February 2019 , pp. 106 - 109
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Prof M R Ahmed takes responsibility for the integrity of the content of the paper

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