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The effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma

Published online by Cambridge University Press:  17 May 2019

F C Akin Ocal ,
G G Kesici ,
S G Gurgen ,
R Ocal  and
S Erbek
F C Akin Ocal*
Affiliation:
Otorhinolaryngology Clinic, Gulhane Training and Research Hospital, Ankara, Turkey
G G Kesici
Affiliation:
Otorhinolaryngology Clinic, Ataturk Training and Research Hospital, Ankara, Turkey
S G Gurgen
Affiliation:
Department of Histology and Embryology, Celal Bayar University, Manisa, Turkey
R Ocal
Affiliation:
Otorhinolaryngology Clinic, Ataturk Training and Research Hospital, Ankara, Turkey
S Erbek
Affiliation:
Department of Otorhinolaryngology, Baskent University, Ankara, Turkey
*
Author for correspondence: Dr F Ceyda Akin Ocal, Otorhinolaryngology Clinic, Gulhane Training and Research Hospital, 38000 Ankara, Turkey E-mail: [email protected]
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Abstract

Objective

To investigate whether oxytocin can prevent ototoxicity related to acoustic trauma.

Methods

Twenty-eight rats were divided into four groups: noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups.

Results

In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma.

Conclusion

Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment.

Keywords

Acoustic TraumaAuditory Brainstem ResponsesDistortion Product Otoacoustic EmissionHearing Loss
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 6 , June 2019 , pp. 466 - 476
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr F C Akin Ocal takes responsibility for the integrity of the content of the paper

Presented at the ENT World Congress, 24–28 June 2017, Paris, France.

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