Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-28T16:05:44.407Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity

Published online by Cambridge University Press:  04 September 2012

M Topdag ,
M Iseri ,
E Gelenli ,
M Yardimoglu ,
Y Yazir ,
S A Ulubil ,
D O Topdag  and
E Ustundag
M Topdag*
Affiliation:
Department of Otolaryngology, Kocaeli University, Turkey
M Iseri
Affiliation:
Department of Otolaryngology, Kocaeli University, Turkey
E Gelenli
Affiliation:
Department of Histology and Embryology, Kocaeli University, Turkey
M Yardimoglu
Affiliation:
Department of Histology and Embryology, Kocaeli University, Turkey
Y Yazir
Affiliation:
Department of Histology and Embryology, Kocaeli University, Turkey
S A Ulubil
Affiliation:
Acibadem Fulya Hospital, Department of Otolaryngology, Istanbul, Turkey
D O Topdag
Affiliation:
Department of Otolaryngology, Kocaeli University, Turkey
E Ustundag
Affiliation:
Department of Otolaryngology, Kocaeli University, Turkey
*
Address for correspondence: Dr Murat Topdag, Kocaeli Universitesi Tip Fakultesi Hastanesi KBB ABD, Umuttepe, Kocaeli 41380, Turkey Fax: +90 262 303 8003 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

This study aimed to contribute to the literature on the prevention and treatment of ototoxicity due to various drugs and chemicals.

Material and methods:

This study compared the histological effects of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity, in 36 rats.

Results:

Dexamethasone and memantine had significant effects on the stria vascularis, organ of Corti and spiral ganglion (p < 0.05). Although piracetam decreased the apoptosis rate, this effect was not statistically significant (p > 0.05).

Conclusion:

Dexamethasone and memantine were found superior to piracetam in reducing apoptosis due to cisplatin ototoxicity. Further studies of this subject are needed, incorporating electron microscopy and auditory brainstem response testing.

Keywords

Ear, InnerRatOtotoxicityDexamethasoneMemantinePiracetam
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 11 , November 2012 , pp. 1091 - 1096
Copyright
Copyright © JLO (1984) Limited 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Frankfurt, OS, Robb, JA, Sugarbaker, EV, Villa, L. Monoclonal antibody to single-stranded DNA is a specific and sensitive cellular marker of apoptosis. Exp Cell Res 1996;226:387–97CrossRefGoogle ScholarPubMed
2 Manesse, M, Delverdier, M, Abella-Bourges, N, Sautet, J, Cabanié, P, Schelcher, F. An immunohistochemical study of bovine palatine and pharyngeal tonsils at 21, 60 and 300 days of age. Anat Histol Embryol 1998;27:179–85CrossRefGoogle Scholar
3 Gundersen, HJ, Jensen, EB. The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987;147:229–63Google Scholar
4 Peters, RC, Mommersteeg, PMC, Heijmen, PS. The electroreceptor organ of the catfish, Ictalurus melas, as a model for cisplatin induced ototoxicity. Neuroscience 1999;91:745–51CrossRefGoogle Scholar
5 Ravi, R, Somani, SM, Rybak, LP. Mechanism of cisplatin ototoxicity: antioxidant system. Pharmacol Toxicol 1995;76:386–94CrossRefGoogle ScholarPubMed
6 Dehne, N, Lautermann, J, Petrat, F. Cisplatin ototoxicity. Involvement of iron and enhanced formation of superoxide anion radicals. Toxicol Appl Pharmacol 2001;174:27–34 CrossRefGoogle ScholarPubMed
7 Rybak, LP, Whitworth, C, Somani, S. Application of antioxidants and other agents to prevent cisplatin ototoxicity. Laryngoscope 1999;109:1740–4Google Scholar
8 Muldoon, LL, Pagel, MA, Kroll, RA. Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity. Clin Cancer Res 2000;6:309–15Google ScholarPubMed
9 Campbell, KCM, Meech, RP, Rybak, LP, Hughes, LF. D-Methionine protects against cisplatin damage to the stria vascularis. Hear Res 1999;138:13–28 Google Scholar
10 Feghali, JG, Liu, W, Van De Water, TR. L-n-acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity. Laryngoscope 2001;111:1147–55CrossRefGoogle ScholarPubMed
11 Rybak, LP, Husain, K, Morris, C. Effect of protective agents against cisplatin ototoxicity. Am J Otol 2000;21:513–20Google ScholarPubMed
12 Nadel, DM. The use of systemic steroids in otolaryngology. Ear Nose Throat J 1996;75:502–6Google Scholar
13 Schimmer, BP, Parker, KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman, JG, Limbird, LE, Molinoff, PB, Ruddon, RW, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th edn. New York: McGraw-Hill, 1996;1459–85Google Scholar
14 Alexiou, C, Arnold, W, Fauser, C, Schratzenstaller, B, Gloddek, B, Fuhrmann, S. Sudden sensorineural hearing loss: does application of glucocorticoids make sense? Arch Otolaryngol Head Neck Surg 2001;127:253–8Google Scholar
15 Chen, C-Y, Halpin, C, Rauch, SD. Oral steroid treatment of sudden sensorineural hearing loss: a ten year retrospective analysis. Otol Neurotol 2003;24:728–33CrossRefGoogle ScholarPubMed
16 Eisenman, DJ, Arts, A. Effectiveness of treatment for sudden sensorineural hearing loss. Arch Otolaryngol Head Neck Surg 2000;126:1161–6CrossRefGoogle ScholarPubMed
17 Sha, WC, Liou, H, Tuomanen, EI, Baltimore, D. Targeted disruption of the p50 subunit of NF-κβ leads to multifocal defects in immune responses. Cell 1995;80:321–30Google Scholar
18 Baeuerle, PA, Baltimore, D. NF-κβ: ten years after. Cell 1996;87:13–20 Google Scholar
19 Ma, W, Gee, K, Lim, W. Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-κβ transcription factors. J Immunol 2004;172:318–30CrossRefGoogle Scholar
20 Almawi, WY, Melemedjian, OD. Negative regulation of nuclear factor-κβ activation and function by glucocorticoids. J Mol Endocrinol 2002;28:69–78 CrossRefGoogle Scholar
21 Trune, DR, Kempton, JB. Aldosterone and prednisolone control of auditory dysfunction in MRL/MpJ-Faslpr autoimmune mice. Hear Res 2001;155:9–20 Google Scholar
22 Himeno, C, Komeda, M, Izumikawa, M. Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig. Hear Res 2002;167:61–70 Google Scholar
23 Tabuchi, K, Oikawa, K, Uemaetomari, I, Tsuji, S, Wada, T, Hara, A. Glucocorticoids and dehydroepiandrosterone sulfate ameliorate ischemia-induced injury of the cochlea. Hear Res 2003;180:51–60 CrossRefGoogle ScholarPubMed
24 Sekiya, T, Shimamura, N, Suzuki, S, Hatayama, T. Methylprednisolone ameliorates cochlear nerve degeneration following mechanical injury. Hear Res 2001;151:125–32CrossRefGoogle ScholarPubMed
25 Lamm, K, Arnold, W. The effect of prednisolone and non-steroidal antiinflammatory agents on the normal and noise-damaged guinea pig inner ear. Hear Res 1998;115:149–61Google Scholar
26 Takemura, K, Komeda, M, Yagi, M. Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig. Hear Res 2004;196:58–68 Google Scholar
27 Oestreicher, E, Arnold, W, Ehrenberger, K, Felix, D. Memantine suppresses the glutamatergic neurotransmission of mammalian inner hair cells. ORL J Otorhinolaryngol Relat Spec 1998;60:18–21 CrossRefGoogle ScholarPubMed
28 Oliver, D, Ludwig, J, Reisinger, E, Zoellner, W, Ruppersberg, JP, Fakler, B. Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells. Mol Pharmacol 2001;60:183–9Google Scholar
29 Gabryel, B, Adamek, M, Pudelko, A, Malecki, A, Trzeciak, HI. Piracetam and vinpocetine exert cytoprotective activity and prevent apoptosis of astrocytes in vitro in hypoxia and reoxygenation. Neurotoxicology 2002;23:19–31 Google Scholar
30 Altas, E, Ertekin, VM, Kuduban, O, Gündogdu, C, Demirci, E, Sütbeyaz, Y. Effects of piracetam supplementation on cochlear damage occuring in guinea pigs exposed to irradiation. Biol Pharm Bull 2006;29:1460–5CrossRefGoogle ScholarPubMed
31 Altas, E, Ucuncu, H, Aktan, B, Selimoglu, E. The effect of piracetam in preventing combined cisplatin and gentamicin induced ototoxicity in a guinea pig model. Pain Clinic 2004;16:427–35Google Scholar