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Effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray on clinical signs and quality of life of patients with streptococcal tonsillopharyngitis: multicentre, prospective, randomised, double-blinded, placebo-controlled study

Published online by Cambridge University Press:  11 February 2011

C Cingi ,
M Songu ,
A Ural ,
N Erdogmus ,
M Yildirim ,
H Cakli  and
C Bal
C Cingi
Affiliation:
Department of Otorhinolaryngology, Osmangazi University Medical Faculty, Eskisehir, Turkey
M Songu
Affiliation:
Department of Otorhinolaryngology, Izmir Ataturk Research and Training Hospital, Izmir, Turkey
A Ural*
Affiliation:
Department of Otorhinolaryngology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey
N Erdogmus
Affiliation:
Department of Otorhinolaryngology, Osmangazi University Medical Faculty, Eskisehir, Turkey
M Yildirim
Affiliation:
Department of Otorhinolaryngology, Dicle University Medical Faculty, Diyarbakir, Turkey
H Cakli
Affiliation:
Department of Otorhinolaryngology, Osmangazi University Medical Faculty, Eskisehir, Turkey
C Bal
Affiliation:
Department of Biostatistics, Osmangazi University Medical Faculty, Eskisehir, Turkey
*
Address for correspondence: Dr Ahmet Ural, Karadeniz Teknik Üniversitesi Tıp Fakültesi Farabi Hastanesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, 61080 Trabzon, Turkey Fax: +904623250518 E-mail: [email protected]
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Abstract

Objective:

To assess the effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray, used in conjunction with antibiotic treatment, on the intensity of clinical signs and quality of life of patients with group A streptococcal tonsillopharyngitis.

Methods:

Patients (n = 147) with streptococcal tonsillopharyngitis were recruited and randomly allocated to either the treatment group (penicillin plus chlorhexidine and benzydamine; n = 72) or control group (penicillin plus placebo; n = 75). Blinded assessments were conducted before and after 10 days' treatment, using an intensity rating scale for clinical sign severity, a visual analogue scale for subjective health state, the Short Form 36 Health Questionnaire for quality of life, and a customised questionnaire for side effects.

Results:

The treatment group showed a statistically significant reduction in the intensity of clinical signs, compared with the control group. On treatment day 7, there was no significant difference in quality of life between the treatment and control groups. The treatment drugs were well tolerated, and no serious adverse events were observed.

Conclusion:

Chlorhexidine gluconate and benzydamine hydrochloride mouth spray, added to standard antibiotic treatment, significantly alleviate the intensity of clinical signs in patients with streptococcal pharyngitis. Further research is needed using larger sample sizes or alternative control groups.

Keywords

PharyngitisTonsillitisChlorhexidineBenzydamineTherapeutics
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 6 , June 2011 , pp. 620 - 625
Copyright
Copyright © JLO (1984) Limited 2011

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