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Effect of antioxidants on the clinical outcome of patients with nasal polyposis

Published online by Cambridge University Press:  14 June 2011

M Sagit ,
H Erdamar ,
C Saka ,
S Yalcin  and
I Akin
M Sagit*
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Kayseri, Turkey
H Erdamar
Affiliation:
Department of Medical Biochemistry, Tunceli Government Hospital, Tunceli, Turkey
C Saka
Affiliation:
Department of ENT, Dıskapi Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
S Yalcin
Affiliation:
Department of Anesthesiology, Harran University School of Medicine, Sanliurfa, Turkey
I Akin
Affiliation:
Department of ENT, Dıskapi Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
*
Address for correspondence: Dr Mustafa Sagit, ENT Department, Kayseri Eğitim ve Araştırma Hastanesi KBB KliniğiSanayi Mah. Atatürk Bulvarı Hastane Cad. No: 78 38010, Kayseri, Turkey Fax: +90 352 320 73 13 E-mail: [email protected]
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Abstract

Aim:

To investigate the therapeutic effects of antioxidants on the clinical and biochemical outcome of patients with nasal polyposis.

Methods:

Thirty-four patients with nasal polyposis were divided into two groups receiving either intranasal steroid or intranasal steroid plus per-oral vitamins A, C and E and selenium. Paranasal sinus computed tomography, endoscopy, and polyp tissue and serum sampling were conducted pre- and post-therapy. Serum levels of malondialdehyde, superoxide dismutase, nitrite and myeloperoxidase and tissue levels of malondialdehyde and superoxide dismutase were measured. Group results were compared using the Mann–Whitney U test and Wilcoxon signed-rank test.

Results:

Both groups had significantly lower tissue parameters, computed tomography scores and serum malondialdehyde levels, comparing pre- versus post-treatment results. Post-treatment, the steroid plus antioxidant group had significantly lower tissue malondialdehyde levels and a greater fall in tissue and serum malondialdehyde, compared with the steroid group.

Conclusion:

Serum and tissue levels of malondialdehyde (an oxidative marker) were significantly decreased by adding antioxidants to standard therapy. This is the first report of the positive effects of adding antioxidants to steroid therapy for nasal polyposis.

Keywords

Nasal PolypsOxidative StressAntioxidantsPathologyTherapeutics
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 8 , August 2011 , pp. 811 - 815
Copyright
Copyright © JLO (1984) Limited 2011

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