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Do patients with p16-positive oropharyngeal squamous cell carcinoma get more bone metastasis than p16-negative patients?

Published online by Cambridge University Press:  12 February 2018

A S Harris ,
R G Thomas  and
C D Passant
A S Harris*
Affiliation:
Aneurin Bevan University Health Board, Newport, Cardiff, Wales, UK
R G Thomas
Affiliation:
Aneurin Bevan University Health Board, Newport, Cardiff, Wales, UK
C D Passant
Affiliation:
Aneurin Bevan University Health Board, Newport, Cardiff, Wales, UK
*
Address for correspondence: Mr Andrew S Harris, Ear, Nose and Throat Department, Royal Gwent Hospital, Cardiff Road, Newport NP20 2UB, Wales, UK E-mail: [email protected]
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Abstract

Background:

Oropharyngeal squamous cell carcinoma is thought to rarely metastasise to bone. This study hypothesised that in p16-positive disease there is a significant incidence of bony metastasis.

Methods:

This was an ambispective cohort review. All patients with oropharyngeal squamous cell carcinoma diagnosed and treated at one centre were included.

Results:

A total of 180 consecutive patients were identified over 5 years. Fifteen patients were excluded because of lack of p16 status, none of whom had bony metastasis. The final analysis included 165 patients: 48 (29.09 per cent) in the p16-negative group and 117 (70.91 per cent) in the p16-positive group. Ten patients (8.55 per cent) in the p16-positive group developed bony metastasis, compared with zero in the p16-negative group; this difference was statistically significant (p = 0.036).

Conclusion:

Expression of p16 was associated with an increased incidence in bony metastasis in this cohort. This is the first study to explore this specific question.

Keywords

CarcinomaSquamous CellOropharyngeal NeoplasmsTonsillar NeoplasmsPapillomaviridaeNeoplasm Metastasis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 5 , May 2018 , pp. 429 - 433
Copyright
Copyright © JLO (1984) Limited 2018 

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Footnotes

Presented as a poster at the British Association of Head and Neck Oncology (‘BAHNO’) Annual Scientific Meeting, 12 May 2017, London, UK.

References

1Takes, RP, Rinaldo, A, Silver, CE, Haigentz, M Jr, Woolgar, JA, Triantafyllou, A et al. Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects. Oral Oncol 2012;48:775–9.CrossRefGoogle ScholarPubMed
2Ferlito, A, Shaha, AR, Silver, CE, Rinaldo, A, Mondin, V. Incidence and sites of distant metastases from head and neck cancer. ORL J Otorhinolaryngol Relat Spec 2001;63:202–7.Google Scholar
3Kowalski, LP, Carvalho, AL, Priante, AV, Magrin, J. Predictive factors for distant metastasis from oral and oropharyngeal squamous cell carcinoma. Oral Oncol 2005;41:534–41.Google Scholar
4Gooi, Z, Chan, JY, Fakhry, C. The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope 2016;126:894–900.CrossRefGoogle ScholarPubMed
5Wittekindt, C, Gültekin, E, Weissenborn, SJ, Dienes, HP, Pfister, HJ, Klussmann, JP. Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival. Adv Otorhinolaryngol 2005;62:72–80.Google ScholarPubMed
6Huang, SH, Perez-Ordonez, B, Liu, FF, Waldron, J, Ringash, J, Irish, J et al. Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 2012;82:276–83.CrossRefGoogle ScholarPubMed
7Müller, S, Khuri, FR, Kono, SA, Beitler, JJ, Shin, DM, Saba, NF. HPV positive squamous cell carcinoma of the oropharynx. Are we observing an unusual pattern of metastases? Head Neck Pathol 2012;6:336–44.CrossRefGoogle ScholarPubMed
8Haigentz, M Jr, Hartl, DM, Silver, CE, Langendijk, JA, Strojan, P, Paleri, V et al. Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment. Oral Oncol 2012;48:787–93.CrossRefGoogle ScholarPubMed