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Clinical monitoring of the effects of gentamicin by electrocochleography*

Published online by Cambridge University Press:  29 June 2007

Malcolm Keene  and
John M. Graham
Malcolm Keene
Affiliation:
London
John M. Graham
Affiliation:
London
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Abstract

Eight patients receiving prolonged treatment with gentamicin for bacterial endocarditis were monitored for possible ototoxicity using transtympanic electrocochleography as an adjunct to pure tone audiometry, vestibular function tests and serum gentamicin levels. An immediate effect of intravenous gentamicin on the cochlea, shown by changes in the whole nerve action potential and/or cochlear microphonic was recorded in seven patients, none of whom had experienced vestibular or auditory symptoms with gentamicin prior to testing. Two patients subsequently developed evidence of vestibular dysfunction, and a high frequency sensorineural hearing loss occurred in a third individual. There have been no previous report of the immediate effects of gentamicin on the human cochlea to date. The significance of these findings in routine clinical monitoring of ototoxicity is discussed in the light of clinical and animal evidence for the possible mode of action of aminoglycosides on the auditory and vestibular apparatus.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 98 , Issue 1 , January 1984 , pp. 11 - 21
Copyright
Copyright © JLO (1984) Limited 1984

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