Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-04T17:56:54.570Z Has data issue: false hasContentIssue false
  • English
  • Français

Cisplatin in children: hearing loss correlates with iris and skin pigmentation

Published online by Cambridge University Press:  29 June 2007

N. Wendell Todd ,
Carlos S. Alvarado  and
Debra B. Brewer
N. Wendell Todd*
Affiliation:
Departments of Surgery (Otolaryngology), Emory University School of Medicine, Atlanta. Department of Pediatrics, Emory University School of Medicine, Atlanta.
Carlos S. Alvarado
Affiliation:
Department of Pediatrics, Emory University School of Medicine, Atlanta.
Debra B. Brewer
Affiliation:
The Section of Otolaryngology, Emory Clinic, Atlanta, Georgia, USA.
*
Dr N. Wendell Todd, Department of Surgery (Otolaryngology), Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, Georgia 30322, USA. Fax: 404 778 4295
Get access Rights & Permissions [Opens in a new window]

Abstract

Pigmentation is reported to affect cisplatin-induced ototoxicity in adult humans. The hearing loss is worse in people with brown irises, than in those with blue irises. We assessed the hypothesis that cisplatintreated children with dark irises suffer more deterioration in auditory thresholds than do those with less pigmentation. For the 19 children whose data met the requirements of this observational retrospective study, we found a weak correlation (Spearman's r = 0.50; p>0.05) of high frequency hearing loss (at 4000 Hz) and pigmentation. Blue or hazel-eyed children averaged 2.9 dB worsening at 4000 Hz, in contrast to 14.2 dB worsening for brown or black-eyed children.

Pigmentation may account for some of the individual susceptibility to cisplatin ototoxicity. We suggest that iris colour be included in future reports of cisplatin-related hearing loss

Keywords

CisplatinOtotoxicityChild
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 10 , October 1995 , pp. 926 - 929
Copyright
Copyright © JLO (1984) Limited 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barr-Hamilton, R. M., Matheson, L. M., Keay, D. G. (1991) Ototoxicity of cis-platinum and its relationship to eye colour. Journal of Laryngology and Otology 105: 105–7.CrossRefGoogle ScholarPubMed
Blakley, B. W., Myers, S. F. (1993) Patterns of hearing loss resulting from cis-platinum therapy. Otolaryngology – Head and Neck Surgery 109: 109–385.CrossRefGoogle ScholarPubMed
Brock, P. R., Bellman, S. C., Yeomans, E. C., Pinkerton, C. R., Pritchard, J. (1991) Cisplatin ototoxicity in children: a practical grading system. Medical and Pediatric Oncology 19: 19–295.CrossRefGoogle ScholarPubMed
Carlin, M. F., McCrosky, R. L. (1980) Is the eye color a predictor of noise induced hearing loss? Ear and Hearing 1: 1–191.CrossRefGoogle ScholarPubMed
Carter, N. L. (1980) Eye colour and susceptibility to noiseinduced permanent threshold shift. Audiology 19: 19–86.Google ScholarPubMed
Fausti, S. A., Henry, J. A., Schaffer, H. I., Olson, D. J., Frey, R. H., BagbyJr, G. C. Jr, G. C. (1993) High-frequency monitoring for early detection of cisplatin ototoxicity. Archives of Otolaryngology - Head and Neck Surgery 119: 119–661.CrossRefGoogle ScholarPubMed
Ford, A. H., Rybak, L. P. (1993) Potentiation of the ototoxic effect of cisplatin by hyperbaric oxygen therapy. Otolaryngology – Head and Neck Surgery 109: 218.Google Scholar
Lane, A. T. (1988) Physical injury. In Pediatric Dermatology. (Schachner, L. A., Hansen, R. C, eds.), Churchill-Livingstone. New York, pp 1619–1641.Google Scholar
Laurell, G., Jungnelius, U. (1990) High-dose cisplatin treatment: hearing loss and plasma concentrations. Laryngoscope 100: 100–724.CrossRefGoogle ScholarPubMed
Rybak, L. P. (1981) Cis-platinum associated hearing loss. Journal of Laryngology and Otology 95: 95–745.CrossRefGoogle ScholarPubMed
Schweitzer, V. G. (1993 a) Cisplatin-induced ototoxicity: effect of pigmentation and inhibitory agents. Laryngoscope 103: (4): 1–52.Google ScholarPubMed
Schweitzer, V. G. (1993 b) Ototoxicity of chemotherapeutic agents. Otolarvngologic Clinics of North America 26: 26–759.Google ScholarPubMed