Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-07T23:19:42.495Z Has data issue: false hasContentIssue false
  • English
  • Français

Cervical extraskeletal Ewing's sarcoma: case report demonstrating radiological features and management

Published online by Cambridge University Press:  07 June 2007

S Ali ,
K MacKenzie ,
R Reid ,
G O'Neill  and
I Ganly
S Ali
Affiliation:
Department of Otolaryngology, Glasgow Royal Infirmary, Scotland, UK
K MacKenzie
Affiliation:
Department of Otolaryngology, Glasgow Royal Infirmary, Scotland, UK
R Reid
Affiliation:
Department of Pathology, Glasgow Royal Infirmary, Scotland, UK
G O'Neill
Affiliation:
Department of Radiology, Glasgow Royal Infirmary, Scotland, UK
I Ganly*
Affiliation:
Department of Otolaryngology, Glasgow Royal Infirmary, Scotland, UK
*
Address for correspondence: Mr Ian Ganly, Department of Otolaryngology and Head and Neck Surgery, Edinburgh Royal Infirmary, Lauriston Building, Lauriston Place, Edinburgh EH3 9HA, Scotland, UK. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Extraskeletal Ewing's sarcoma is a rare tumour of mesenchymal origin, which is histologically similar to primary osseous Ewing's sarcoma. The majority of cases have been reported in the lower limb and paravertebral region, with a few cases reported in the neck.

Methods:

We report a patient with extraskeletal Ewing's sarcoma presenting with a right-sided neck mass, vocal fold palsy and T1 nerve root involvement. The detection of characteristic features on computed tomography and magnetic resonance imaging scans, in conjunction with histological analysis, was required to make the diagnosis.

Results:

Radiological imaging demonstrated that the tumour was infiltrating through the neural exit foramina of the lower cervical nerve roots, with encasement of the vertebral artery. The patient was managed with combination chemotherapy for systemic control and irradiation for local control.

Conclusion:

Extraskeletal Ewing's sarcoma has a propensity to occur in a paravertebral location, being found rarely in the cervical region, and has a predilection to infiltrate through neural exit formina. Computed tomography and magnetic resonance imaging are helpful in the diagnosis of this rare tumour.

Keywords

SarcomaNeoplasms, Bone TissueNeckTreatmentDisease Management
Type
Clinical Record
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 9 , September 2008 , pp. 998 - 1001
Copyright
Copyright © JLO (1984) Limited 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 West, DC. Ewing sarcoma family of tumors. Curr Opin Oncol 2000;12:323–9CrossRefGoogle ScholarPubMed
2 Thacker, MM, Temple, HT, Scully, SP. Current treatment for Ewing's sarcoma. Expert Rev Anticancer Ther 2005;5:319–31CrossRefGoogle ScholarPubMed
3 Wexler, LH, DeLaney, TF, Tsokos, M, Avila, N, Steinberg, SM, Weaver-McClure, L et al. Ifosfamide and etoposide plus vincristine, doxorubicin, and cyclophosphamide for newly diagnosed Ewing's sarcoma family of tumors. Cancer 1996;78:901–113.0.CO;2-X>CrossRefGoogle ScholarPubMed
4 Tefft, M, Vawter, GF, Mitus, A. Paravertebral round cell tumors in children. Radiology 1969;92:1501–9CrossRefGoogle ScholarPubMed
5 Angervall, L, Enzinger, FM. Extraskeletal neoplasm resembling Ewing sarcoma. Cancer 1975;36:240–513.0.CO;2-H>CrossRefGoogle Scholar
6 O'Keefe, F, Lorigan, JG, Wallace, S. Radiological features of extraskeletal Ewing sarcoma. Br J Radiol 1990;63:456–60CrossRefGoogle Scholar
7 Kennedy, JG, Eustace, S, Caulfield, R, Fennelly, DJ, Hurson, B, O'Rourke, KS. Extraskeletal Ewing's sarcoma. Spine 2000;25:1996–9CrossRefGoogle ScholarPubMed
8 Hardasmalani, MD, Naim, FA, Kroning, D, Bithoney, WG. Emergency department presentations of a rare tumor – extraosseous cervical paraspinal Ewing's sarcoma. J Emerg Med 2002;24:271–5CrossRefGoogle Scholar
9 Modrego, PJ, Pina, MA. Extraskeletal Ewing's sarcoma presenting with neurological symptoms. Report of two cases. Neurol Sci 2001;22:257–9CrossRefGoogle ScholarPubMed
10 Carvajal, R, Meyers, P. Ewing's sarcoma and primitive neuroectodermal family of tumors. Hematol Oncol Clin North Am 2005;19:501–25CrossRefGoogle ScholarPubMed
11 Longhi, A, Setola, E, Versari, M, Bacci, G. The role of chemotherapy in the treatment of bone and soft tissue sarcomas. Current Orthopaedics 2005;19:119–26CrossRefGoogle Scholar
12 Bacci, G, Longhi, A, Briccoli, A, Bertoni, F, Versari, M, Picci, P. The role of surgical margins in treatment of Ewing's sarcoma family tumors: experience of a single institution with 512 patients treated with adjuvant and neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 2006;65:766–72CrossRefGoogle ScholarPubMed
13 La, TH, Meyeres, PA, Wexler, LH, Alektiar, KM, Healey, JH, Laquaglia, MP et al. Radiation therapy for Ewing's sarcoma: results from Memorial Sloan Kettering in the modern era. Int J Radiat Oncol Biol Phys 2006;64:544–50CrossRefGoogle ScholarPubMed
14 Krasin, MJ, Davidoff, AM, Rodriquez-Galindo, C, Billups, CA, Fuller, CE, Neel, MD et al. Definitive surgery and multiagent systemic therapy for patients with localised Ewing sarcoma family of tumors: local outcome and prognostic factors. Cancer 2005;104:367–73CrossRefGoogle ScholarPubMed
15 Bacci, G, Longhi, A, Ferrari, S, Mercuri, M, Barbieri, E, Bertoni, F et al. Pattern of relapse in 290 patients with nonmetastatic Ewing's sarcoma family tumors treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. Eur J Surg Oncol 2006;32:974–9CrossRefGoogle Scholar
16 McTiernan, A, Driver, D, Michelagnoli, MP, Kilby, AM, Whelan, JS. High dose chemotherapy with bone marrow or peripheral stem cell rescue is an effective treatment option for patients with relapsed or progressive Ewing's sarcoma family of tumours. Ann Oncol 2006;17:1301–5CrossRefGoogle ScholarPubMed