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Biological therapy of salivary duct carcinoma

Published online by Cambridge University Press:  11 April 2008

M Nashed  and
R J Casasola
M Nashed*
Affiliation:
Oncology Department, Ninewells Hospital & Medical School, Dundee, Scotland, UK
R J Casasola
Affiliation:
Oncology Department, Ninewells Hospital & Medical School, Dundee, Scotland, UK
*
Address for correspondence: Dr M Nashed, Oncology Department, Ninewells Hospital & Medical School, Dundee DD1 9SY, Scotland, UK. E-mail: [email protected]
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Abstract

Background:

The incidence of human epidermal growth factor receptor 2 positivity in salivary duct carcinoma ranges from 25 to 100 per cent and is associated with a poor outcome. Salivary duct carcinoma has significant pathological similarities to ductal carcinoma of the breast.

Methods and results:

A 49-year-old man developed lung and liver metastasis a few months after surgery and adjuvant radiotherapy for salivary duct carcinoma of the parotid gland. There was no response to palliative chemotherapy with doxorubicin. We followed the biological model of breast cancer, whereby two-thirds of human epidermal growth factor receptor 2 positive patients respond to a combination of docetaxel and human epidermal growth factor receptor 2 blocker (trastuzumab). A durable, complete response was achieved with this combination. A rationalised treatment approach targeting the biological characteristics of salivary duct carcinoma had proven successful.

Keywords

Salivary DuctCarcinomaTrastuzumabDocetaxelHer-2
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 2 , February 2009 , pp. 250 - 252
Copyright
Copyright © JLO (1984) Limited 2008

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