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Adult cystic hygroma: successful use of OK-432 (Picibanil®)

Published online by Cambridge University Press:  23 April 2008

S L Woolley*
Affiliation:
Emergency Department, Bristol Royal Infirmary, University Hospital of Wales, Cardiff, Wales, UK
D R K Smith
Affiliation:
Otolaryngology Department, University Hospital of Wales, Cardiff, Wales, UK
S Quine
Affiliation:
Otolaryngology Department, University Hospital of Wales, Cardiff, Wales, UK
*
Address for correspondence: Dr Sarah L Woolley, Consultant, Emergency Department, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8BJ, UK. Fax: +44 117 928 2713 E-mail: [email protected]

Abstract

Objective:

We report an adult case of cystic lymphangioma treated with OK-432 (Picibanil®).

Method:

A case report and review of the literature concerning the use of OK-432 to treat cystic lymphangioma is presented.

Results:

A 31-year-old woman developed a cystic lymphangioma four weeks post-partum. This was treated initially by aspiration, for diagnostic purposes. Investigation suggested that surgery would be challenging. A review of the literature demonstrated success with OK-432 in the treatment of this condition, although primarily in the paediatric population. This patient was successfully treated thus, and at the time of writing remained symptom free. A suggested management plan is outlined.

Conclusion:

Treatment with OK-432 is useful in the management of cystic lymphangiomas in adults and should be considered as first line treatment.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 2008

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References

1 Orvidas, LT, Kasperbauer, JL. Pediatric lymphangiomas of the head and neck. Ann Otol Rhinol Laryngol 2000;109:411–21CrossRefGoogle ScholarPubMed
2 Sherman, BE, Kendall, KE. A unique case of the rapid onset of a large cystic hygroma in the adult. Am J Otolaryngol 2001;22:206–10CrossRefGoogle ScholarPubMed
3 Ogita, S, Tsuto, T, Tokiwa, K, Takahashi, T. Intracystic injection of OK-432: a new sclerosing therapy for cystic hygroma in children. Br J Surg 1987;74:690–1CrossRefGoogle ScholarPubMed
4 Ogita, S, Tsuto, T, Deguchi, E, Tokiwa, K, Nagashima, M, Iwai, N. OK-432 therapy for unresectable lymphangiomas in children. J Ped Surg 1991;26:263–70CrossRefGoogle ScholarPubMed
5 Ogita, S, Tsuto, T, Nakamura, K, Deguchi, E, Iwai, N. OK-432 therapy in 64 patients with lymphangiomas. J Ped Surg 1994;29:784–5CrossRefGoogle Scholar
6 Greinwald, JH Jr, Burke, DK, Sato, Y, Poust, RI, Kimura, K, Bauman, NM et al. Treatment of lymphangiomas in children: an update of Picibanil (OK-432) sclerotherapy. Otolaryngol Head Neck Surg 1999;121:381–7CrossRefGoogle ScholarPubMed
7 Smith, R, Burke, D, Sato, Y, Poust, RI, Kimura, K, Bauman, NM. OK-432 therapy for lymphangiomas. Arch Otolaryngol Head Neck Surg 1996;122:1195–9CrossRefGoogle ScholarPubMed
8 Giguere, CM, Bauman, N, Smith, RJH. New treatment options for lymphangioma in infants and children. Ann Otol Rhinol Laryngol 2002;111:1066–75CrossRefGoogle ScholarPubMed
9 Alonso, J, Barbier, L, Alvarez, J, Romo, L, Martin, JC, Artteagoitia, I et al. OK432 (Picibanil) efficacy in an adult with cystic cervical lymphangioma. A case report. Oral Surg Oral Med Oral Pathol 2005;10:362–6Google Scholar
10 Sichel, JY, Udassin, R, Gozal, D, Koplewitz, BZ, Dano, I, Eliashar, R. OK-432 Therapy for cervical lymphangioma. Laryngoscope 2004;114:1805–9CrossRefGoogle ScholarPubMed
11 Landing, BH, Farber, S. Tumors of the cardiovascular system. In: Atlas of Tumor Pathology. Washington DC: Armed Forces Institute of Pathology, 1956Google Scholar
12 Mulliken, JB, Young, AE. Lymphatic malformations. In: Mulliken, John B. Vascular Birthmarks, Hemangiomas and Malformations. Philadelphia: Saunders, 1988Google Scholar
13 Schefter, RP, Olsen, KD, Gaffey, TA. Cervical lymphangioma in the adult. Otolaryngol Head Neck Surg 1985;93:65–9CrossRefGoogle ScholarPubMed
14 El-Silimy, O, Corney, C. The value of sonography in the management of cystic neck lesions. J Laryngol Otol 1993;107:245–51CrossRefGoogle ScholarPubMed
15 Curran, AJ, Malik, N, McShane, D, Timon, CVI. Surgical management of lymphangiomas in adults. J Laryngol Otol 1996;110:586–9CrossRefGoogle ScholarPubMed
16 Ricciardelli, EJ, Richardson, MA. Cervicofacial cystic hygroma patterns of recurrence and management of the difficult case. Arch Otolaryngol Head Neck Surg 1991;117:546–53CrossRefGoogle ScholarPubMed
17 Martin, JA. Treatment of cystic hygroma. Texas Journal of Medicine 1954;50:217–22Google ScholarPubMed
18 Riechelmann, H, Muehlfay, G, Teck, T. Total, sub-total, and partial surgical removal of cervicofacial lymphangiomas. Arch Otolaryngol Head Neck Surg 1999;125:643–8CrossRefGoogle Scholar
19 Hancock, BJ, StVil, D, Di Lorenzo, M, Blanchard, H. Complications of lymphangiomas in children. Pediatr Surg 1992;27:220–6CrossRefGoogle ScholarPubMed
20 Farmaud, M, Kuttenberger, JJ. A new therapeutic concept for the treatment of cystic hygroma. Oral Surg Oral Med Oral Pathol 1996;81:389–95CrossRefGoogle Scholar
21 Stein, M, Hsu, RK, Schneider, PD, Ruebner, BH, Mina, Y. Alcohol ablation of a mesenteric lymphangioma. J Vasc Interv Radiol 2000;11:247–50CrossRefGoogle ScholarPubMed
22 Dubois, J, Garel, L, Abela, A, Laberge, L, Yazbeck, S. Lymphangiomas in children: percutaneous sclerotherapy with an alcoholic solution of Zein. Radiology 1997;204:651–4CrossRefGoogle ScholarPubMed
23 Yura, J. Bleomycin treatment for cystic hygroma in children. Arch Jpn Chir 1977;46:607–12Google ScholarPubMed
24 Turner, C, Gross, S. Treatment of recurrent suprahyoid cervicofacial lymphangioma with intravenous cyclophosphamide. Am J Pediatric Hematol Oncol 1994;16:325–8Google ScholarPubMed
25 Castanon, M, Margarit, J, Carrasco, R, Vancells, M, Albert, A, Morales, L. Long-term follow up of nineteen cystic lymphangiomas treated with fibrin sealant. J Pediatr Surg 1999;34:1276–9CrossRefGoogle ScholarPubMed
26 Reinhardt, MA, Nelson, SC, Sencer, SF, Bostrom, BC, Kurachek, SC, Nesbit, ME. Treatment of childhood lymphangiomas with interferon-alpha. J Pediatr Hematol Oncol 1997;19:232–6CrossRefGoogle ScholarPubMed
27 Villavicencio, JL. Primum non nocere: is it always true? The use of absolute ethanol in the management of congenital vascular malformations. J Vasc Surg 2001;33:904–6CrossRefGoogle ScholarPubMed
28 Orford, J, Barker, A, Thonell, S, King, P, Murphy, J. Bleomycin therapy for cystic hygroma. J Ped Surg 1995;30:1282–7CrossRefGoogle ScholarPubMed
29 Tanaka, K, Inomata, Y, Utsunomiya, H, Uemoto, S, Asonuma, K, Katayama, T et al. Sclerosing therapy with bleomycin emulsion for lymphangioma in children. Pediatr Surg 1990;5:270–3Google Scholar
30 Gutierrez, San Roman, Barrios, J, Lluna, J, Menor, F, Poquet, J, Ruiz, S. Treatment of cervical lymphangioma using fibrin adhesive. Eur J Pediatr Surg 1993;3:356358Google Scholar
31 Ezekowitz, RA, Mulliken, JB, Folkman, I. Interferon alfa-2a therapy for life-threatening haemangiomas of infancy. NEJM 1992;326:1456–63CrossRefGoogle ScholarPubMed
32 Okamoto, H. Experimental anticancer studies. Part XXXI. On the streptococcal preparation having potent anticancer activity. Jpn J Exp Med 1966;36:175–86Google Scholar
33 Ishida, N, Hoshino, T. A streptococcal preparation as a potent biological response modifier OK-432, 2nd edn. Amsterdam: Excerpta Medica, 1983;2037Google Scholar
34 Giguere, CM, Bauman, N, Sato, Y, Burke, DK, Greinwald, JH, Pransky, S et al. Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial. Arch Otolaryngol Head Neck Surg 2002;128:1137–44CrossRefGoogle ScholarPubMed
35 Schmidt, B, Schimpl, C, Hollwarth, ME. OK-432 therapy of lymphangiomas in children. Eur J Pediatr 1996;153:649–52CrossRefGoogle Scholar
36 Luzzatto, C, Midrio, P, Tchaprassian, Z, Guglielmi, M. Sclerosing treatment of lymphangiomas with OK-432. Arch Dis Child 2000;82:130–4CrossRefGoogle ScholarPubMed
37 Sung, MW, Lee, DW, Kim, DY, Lee, SJ, Hwang, CH, Park, SW et al. Sclerotherapy with Picibanil (OK-432) for congenital lymphatic malformation in the head and neck. Laryngoscope 2001;111:1430–3CrossRefGoogle ScholarPubMed
38 Bresiw, C, Pracy, JP, Albert, DM. Treatment of lymphangiomas of the head and neck in children by intralesional injection of OK-432 (Picinabil). Clin Otolaryngol 2000;25:130–4Google Scholar
39 Laranne, J, Keski-Nisula, L, Rautio, R, Rautiainen, M, Airaksinen, M. OK-432 (Picibanil) therapy for lymphangiomas in children. Eur Arch Otorhinolaryngol 2002;259:274–8CrossRefGoogle ScholarPubMed