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Uptake of diethylcarbamazine by microfilariae and adults of Litomosoides carinii and Dlpetalonema viteae*

Published online by Cambridge University Press:  05 June 2009

V. M. L. Srivastava† ,
D. P. Singh ,
R. K. Chatterjee  and
A. B. Sen
V. M. L. Srivastava†
Affiliation:
Divisions of Biochemistry and Parasitology Central Drug Research Institute, Lucknow-226001, India
D. P. Singh
Affiliation:
Divisions of Biochemistry and Parasitology Central Drug Research Institute, Lucknow-226001, India
R. K. Chatterjee
Affiliation:
Divisions of Biochemistry and Parasitology Central Drug Research Institute, Lucknow-226001, India
A. B. Sen
Affiliation:
Divisions of Biochemistry and Parasitology Central Drug Research Institute, Lucknow-226001, India
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Abstract

Mierofilariae of Litomosoides carinii and Dipetalonema viteae absorbed about ten times as much diethylcarbamazine (DEC) as did their adults, but bound much less. The higher uptake of DEC by the microfilariae might be related to the fact that DEC is microfilariae Binding of DEC: with the parasites supports the view that the microfilarcidal action begins with the fixation of the drug to the microfilariae.

Type
Research Note
Information
Journal of Helminthology , Volume 58 , Issue 3 , September 1984 , pp. 197 - 199
Copyright
Copyright © Cambridge University Press 1984

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References

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