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Treatment of Nippostrongylus brasiliensis in normal and SPF rats using tetramisole loaded into zeolite

Published online by Cambridge University Press:  05 June 2009

S. K. Shaker
Affiliation:
Department of Biological Sciences, University of Salford, Salford, MS 4WT, UK
A. Dyer
Affiliation:
Department of Chemistry and Applied Chemistry, University of Salford, Salford, MS 4WT, UK
D. M. Storey
Affiliation:
Department of Biological Sciences, University of Salford, Salford, MS 4WT, UK

Abstract

Administration to rats of tetramisole loaded into zeolite was more successful in killing adults of Nippostrongylus brasiliensis than the administration of tetramisole alone. The most successful treatment occurred in SPF (Specific Pathogen Free) rats dosed with tetramisole loaded into zeolite and no worms were present in this group at autopsy eight days post-infection. It is concluded that the slow release of drug from the zeolite matrix improved its efficacy, especially in removing worms from low-grade infections.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1992

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References

REFERENCES

Breck, D. W. (1964) Crystalline molecular sieves. Journal of Chemical Education, 41, 679689.CrossRefGoogle Scholar
Breck, D. W. (1974) Zeolite Molecular Sieves: Structure, Chemistry and Uses. N.Y. Wiley Interscience.Google Scholar
Coles, G. C. & Wells, P. D. (1983) The biology of Nippostrongylus brasiliensis in SPF rats. Zeitschrift für Parasitenkunde, 69, 517521.Google Scholar
Cool, W. M. & Willard, J. M. (1982) Effect of clinoptilolite on swine nutrition. Nutrition Reports International, 26, 759766.Google Scholar
Duncombe, V. M., Bolin, T. D., Davis, A. E., Fagan, M. R. & Kelly, J. D. (1979) Nippostrongylus brasiliensis infection in the rat: effect of iron and protein deficiency on the anthelmintic action of mebendazole, pyrantel, piperazine and levamisole. Gut, 20, 305308.CrossRefGoogle Scholar
Dyer, A., Wells, P. D. & Williams, C. D. (1986) Therapeutic compositions for veterinary use. U.K. Patent Application, No. 9606468.Google Scholar
Janssen, P. A. J. (1976) The levamisole story. Progress Research, 20, 347381.Google ScholarPubMed
Nakaue, H. S., Koelliker, J. K. & Pierson, M. L. (1981) Studies with clinoptilolite in poultry. II-Effect of feeding broilers and the direct application of clinoptilolite on clean and reused broiler litter performance and house environment. Poultry Science, 60, 12211228.CrossRefGoogle Scholar
Williams, C. D. (1988) Use of zeolites as slow release agents. Ph.D. Thesis, University of Salford.Google Scholar